Emotional memory in bipolar disorder: Impact of multiple episodes and childhood trauma

Fijtman, Adam; Bücker, Joana; Strange, Bryan A.; Martins, Dayane Santos; Passos, Ives Cavalcante; Hasse-Sousa, Mathias; Lima, Francisco Esmaile de Sales; Kapczinski, Flávio; Yatham, Lakshmi N.; Kauer-Sant’Anna, Márcia

doi:10.1016/j.jad.2019.09.003

Cited by 7 publications

(6 citation statements)

References 78 publications

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“…Furthermore, individuals exposed to emotional neglect also showed worse recognition of angry faces compared to those who were not exposed. 115 This was in contrast to two other studies that did not find an effect of CT exposure on emotion processing or memory performance in individuals with BD, 115,116 but rather reported trauma-related deficits in the performance of a complex Theory of Mind task. 108 Finally, sensory processing is often impaired during emotion processing in affective disorders, but not in individuals with BD exposed to CT. 117…”

contrasting

confidence: 80%

<p>The Impact of Childhood Trauma on Developing Bipolar Disorder: Current Understanding and Ensuring Continued Progress</p>

Quidé¹,

Tozzi²,

Corcoran³

et al. 2020

NDT

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Childhood trauma (CT) has been repeatedly linked to earlier onset and greater severity of bipolar disorder (BD) in adulthood. However, such knowledge is mostly based on retrospective and cross-sectional studies in adults with BD. The first objective of this selective review is to characterize the short-term effects of CT in the development of BD by focusing on studies in young people. The second objective is to describe the longer-term consequences of CT by considering studies with adult participants. This review first outlines the most prominent hypotheses linking CT exposure and the onset of BD. Then, it summarizes the psychological and biological risk factors implicated in the development of BD, followed by a discussion of original studies that investigated the role of CT in young people with early-onset BD, youths at increased risk of developing BD, or young people with BD with a focus on subclinical and clinical outcome measures. The review considers additional biological and psychological factors associated with a negative impact of CT on the long-term course of BD in later adulthood. Finally, we discuss how the integration of information of CT can improve ongoing early identification of BD and mitigate severe clinical expression in later adulthood.

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contrasting

confidence: 80%

<p>The Impact of Childhood Trauma on Developing Bipolar Disorder: Current Understanding and Ensuring Continued Progress</p>

Quidé¹,

Tozzi²,

Corcoran³

et al. 2020

NDT

View full text Add to dashboard Cite

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“…Importantly, it is believed empirically that antidepressant treatment could deprave the natural course of BD and switch from depressive episode to episode of mania, hypomania, or mixed state (Viktorin et al., 2014 ), which may undermine the cognitive performance of bipolar patients (Goodwin et al., 2008 ). For instance, it was found that the higher number of manic and/or hypomanic episodes was negatively correlated with the cognitive performance of euthymic BD patients ( n = 99) such as NCI, visual memory, and working memory in a 5‐year follow‐up longitudinal study (Sánchez‐Morla et al., 2019 ); furthermore, BD patients ( n = 33), especially those with multiple mood episodes including mania, hypomania, and/or mixed state, showed severe impairments in emotional memory than healthy controls ( n = 20) (Fijtman et al., 2020 ). Considering the significantly delayed diagnosis of BD and common use of antidepressants in clinical practice, such potential scathing effects should gather more attention.…”

Section: Discussionmentioning

confidence: 99%

“…Empirically, antidepressant treatment could deprave the natural course of disease and facilitate switching from depressive onset to episodes of mania, hypomania, or mixed state (Berkol et al., 2019 ; Sole et al., 2017 ; Viktorin et al., 2014 ), which may cause cognitive injury (Goodwin et al., 2008 ). For example, BD patients with higher number of manic and/or hypomanic episodes had a worse performance in Neurocognitive Composite Index (NCI), visual memory, and working memory (Sánchez‐Morla et al., 2019 ); furthermore, patients with BD, particularly those with multiple mood episodes, showed severe dysfunction in emotional memory than healthy controls (Fijtman et al., 2020 ). In addition, the number of manic episodes was positively correlated with level of 8‐hydroxy‐2 deoxyguanosine (8‐OHdG), a modulator of DNA methylation, which could be a potential mechanism underlying cognitive dysfunction (Soeiro‐de‐Souza et al., 2013 ).…”

Section: Introductionmentioning

confidence: 99%

“…episodes was negatively correlated with the cognitive performance of euthymic BD patients (n = 99) such as NCI, visual memory, and working memory in a 5-year follow-up longitudinal study(Sánchez-Morla et al, 2019); furthermore, BD patients (n = 33), especially those with multiple mood episodes including mania, hypomania, and/or mixed state, showed severe impairments in emotional memory than healthy controls (n = 20)(Fijtman et al, 2020). Considering the significantly delayed diagnosis of BD and common use of antidepressants in clinical practice, such potential scathing effects should gather more attention.…”

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confidence: 97%

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The effect of systemic antidepressant treatments in early stage on neurocognitive function of euthymic bipolar patients initiated with a depressive onset: An observational, cross‐sectional, single‐blind study protocol

et al. 2021

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Objectives: Patients with bipolar disorder (BD) have a wide range of neurocognitive dysfunction even in euthymic state, leading to impaired psychosocial function and reduced quality of life. However, the understanding on risk factors related to neurocognitive impairment in such group of people is limited. In view of significantly delayed diagnosis of BD and common use of antidepressants prior to the BD diagnosis, the study aims to clarify whether systemic antidepressant use in early stage, defined as from the initial depressive episode to the diagnosis of BD, could impact neurocognitive function of euthymic bipolar patients. Methods: It is an observational, cross-sectional, single-blind trial, making a comparison in neurocognitive function between euthymic bipolar patients who had a depressive episode as initial onset and being with and without systemic antidepressant treatments in early stage (n = 62 and 62, respectively); secondary outcomes include the impact of systemic antidepressant use on global function, quality of life, sleep quality, positive and negative affect, and peripheral level of neuron-specific enolase. Discussion: The study will provide a comprehensive and in-depth understanding on the effect of systemic antidepressant treatments in early stage in such group of patients. It is expected to better guide the related prevention and treatment work of BD management.Trial Registration: The study was registered on Clinicaltrials.gov with protocol ID (TJAH2020-18) and clinicaltrials.gov ID (NCT04564573).

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“…BD is associated with impairments in cognition, and more specifically emotional cognition (Bogie et al, 2019; Fijtman et al, 2020). Patients with BD depression and unipolar depression show a more general impairment in recall and recognition processes, which seem to be related to poor encoding rather than to rapid forgetting (Bearden et al, 2006; Deckersbach et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

A single dose of lamotrigine induces a positive memory bias in healthy volunteers

Zghoul,

Hortelano,

Kaltenboeck

et al. 2023

Preprint

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BackgroundLamotrigine has been shown to be effective in the long-term treatment and relapse prevention of depression in bipolar disorder. However, the neuropsychological mechanisms underlying these effects are unclear. We investigated the effects of lamotrigine on a battery of emotional processing tasks, previously shown to be sensitive to antidepressant drug action in healthy volunteers.MethodsHealthy volunteers (n=36) were randomised in a double blind design to receive a single dose of placebo or 300mg lamotrigine. Mood and subjective effects were monitored throughout the study period and emotional processing was assessed using the Oxford Emotional Test Battery (ETB) 3 hours post administration.ResultsParticipants receiving lamotrigine showed increased accuracy for the recall of positive vs. negative self-descriptors, compared to those in the placebo group. There were no other signficant effects on emotional processing in the ETB, and lamotrigine did not affect ratings of mood or subjective experience.ConclusionsLamotrigine induced a positive bias in emotional memory, similar to the effects of other antidepressants as reported in previous studies. Further work is needed to assess whether similar effects are seen in the clinical treatment of patients with bipolar disorder and the extent to which this is associated with its clinical action in relapse prevention.

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Emotional memory in bipolar disorder: Impact of multiple episodes and childhood trauma

Cited by 7 publications

References 78 publications

<p>The Impact of Childhood Trauma on Developing Bipolar Disorder: Current Understanding and Ensuring Continued Progress</p>

<p>The Impact of Childhood Trauma on Developing Bipolar Disorder: Current Understanding and Ensuring Continued Progress</p>

The effect of systemic antidepressant treatments in early stage on neurocognitive function of euthymic bipolar patients initiated with a depressive onset: An observational, cross‐sectional, single‐blind study protocol

A single dose of lamotrigine induces a positive memory bias in healthy volunteers

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