Emotional neglect in childhood shapes social dysfunctioning in adults by influencing the oxytocin and the attachment system: Results from a population-based study

Müller, Laura E.; Bertsch, Katja; Bülau, Konstantin; Herpertz, Sabine C.; Buchheim, Anna

doi:10.1016/j.ijpsycho.2018.05.011

Cited by 53 publications

(32 citation statements)

References 63 publications

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“…A significant association between emotional neglect and social functioning indicates that emotional support and security from a caregiver in childhood is important in acquiring social skills and forming relationships with others. Emotional neglect in childhood is known to influence social dysfunction in adulthood through the oxytocin level and attachment system in the general population [79]. Empathic ability was also correlated with social functioning in healthy controls.…”

Section: Discussionmentioning

confidence: 99%

Neurophysiological and Psychological Predictors of Social Functioning in Patients with Schizophrenia and Bipolar Disorder

Kim

Kwon

Min

et al. 2019

Psychiatry Investig

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ObjectiveThe aim of this study is to examine social functioning in patients with schizophrenia and bipolar disorder and explore the psychological and neurophysiological predictors of social functioning. MethodsTwenty-seven patients with schizophrenia and thirty patients with bipolar disorder, as well as twenty-five healthy controls, completed measures of social functioning (questionnaire of social functioning), neurocognition (Verbal fluency, Korean-Auditory Verbal Learning Test), and social cognition (basic empathy scale and Social Attribution Task-Multiple Choice), and the childhood trauma questionnaire (CTQ). For neurophysiological measurements, mismatch negativity and heart rate variability (HRV) were recorded from all participants. Multiple hierarchical regression was performed to explore the impact of factors on social functioning. ResultsThe results showed that CTQ-emotional neglect significantly predicted social functioning in schizophrenia group, while HRV-high frequency significantly predicted social functioning in bipolar disorder patients. Furthermore, emotional neglect and HRV-HF still predicted social functioning in all of the subjects after controlling for the diagnostic criteria. ConclusionOur results implicated that even though each group has different predictors of social functioning, early traumatic events and HRV could be important indicators of functional outcome irrespective of what group they are.

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Section: Discussionmentioning

confidence: 99%

Neurophysiological and Psychological Predictors of Social Functioning in Patients with Schizophrenia and Bipolar Disorder

Kim

Kwon

Min

et al. 2019

Psychiatry Investig

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“…There are several studies, however, that demonstrate the involvement of both ω-3 fatty acids and oxytocin in development. For example, higher levels of ω-3 fatty acids in maternal milk are associated with better temperament in children [157], and reduce negative affect and inflammation in children that have mothers with high levels of adiposity [158], while lower levels of oxytocin have been related to experiences of severe emotional neglect and abuse in childhood in plasma and cerebrospinal fluid samples [159,160]. Children raised in orphanages who experienced neglect have also been shown to have lower oxytocin plasma levels [161].…”

Section: Early-life Stress and Microglia: Clinical Studiesmentioning

confidence: 99%

Microglial Function in the Effects of Early-Life Stress on Brain and Behavioral Development

Catale

Gironda

Iacono

et al. 2020

JCM

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The putative effects of early-life stress (ELS) on later behavior and neurobiology have been widely investigated. Recently, microglia have been implicated in mediating some of the effects of ELS on behavior. In this review, findings from preclinical and clinical literature with a specific focus on microglial alterations induced by the exposure to ELS (i.e., exposure to behavioral stressors or environmental agents and infection) are summarized. These studies were utilized to interpret changes in developmental trajectories based on the time at which the stress occurred, as well as the paradigm used. ELS and microglial alterations were found to be associated with a wide array of deficits including cognitive performance, memory, reward processing, and processing of social stimuli. Four general conclusions emerged: (1) ELS interferes with microglial developmental programs, including their proliferation and death and their phagocytic activity; (2) this can affect neuronal and non-neuronal developmental processes, which are dynamic during development and for which microglial activity is instrumental; (3) the effects are extremely dependent on the time point at which the investigation is carried out; and (4) both pre- and postnatal ELS can prime microglial reactivity, indicating a long-lasting alteration, which has been implicated in behavioral abnormalities later in life.

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“…Adverse childhood experiences also correlate with poor general health and quality of life in adulthood [26,27]. Childhood maltreatment also affects social functioning in adulthood [28]; moreover, it poorly affects the socioeconomic status in adulthood [22]. Childhood maltreatment is considered to determine the health-related quality of midlife in women [29] and correlates with intimate partner violence victimization in adulthood [30].…”

Section: Introductionmentioning

confidence: 99%

Structural equation modeling approach to explore the influence of childhood maltreatment in adults

et al. 2020

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Background Childhood maltreatment affects social functioning in the general adult population. However, how child abuse affects functional disability in adulthood remains unknown. Thus, we investigated the correlation between child abuse, depressive symptoms, cognitive complaints, and functional disability in adult community volunteers. Methods Participants (N = 556) completed the Child Abuse and Trauma Scale, Patient Health Questionnaire-9, Cognitive Complaints in Bipolar Disorder Rating Assessment, and Sheehan Disability Scale. Multiple regression analyses and structural equation modeling were performed to evaluate scale correlations. Results Structural equation modeling showed that the direct effect of childhood maltreatment on depressive symptoms, the indirect effect of childhood maltreatment on cognitive function via depressive symptoms, and the indirect effects of childhood maltreatment on functional disability via depressive symptoms and via cognitive function were all significant. The direct effects of childhood maltreatment on cognitive function and functional disability were not significant. There was no significant association between variables. Limitations Cross-sectional designs cannot identify causal relationships between parameters. Participants were adult volunteers from the community; therefore, results may not be generalizable

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Emotional neglect in childhood shapes social dysfunctioning in adults by influencing the oxytocin and the attachment system: Results from a population-based study

Cited by 53 publications

References 63 publications

Neurophysiological and Psychological Predictors of Social Functioning in Patients with Schizophrenia and Bipolar Disorder

Neurophysiological and Psychological Predictors of Social Functioning in Patients with Schizophrenia and Bipolar Disorder

Microglial Function in the Effects of Early-Life Stress on Brain and Behavioral Development

Structural equation modeling approach to explore the influence of childhood maltreatment in adults

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