Neurophysiological and Psychological Predictors of Social Functioning in Patients with Schizophrenia and Bipolar Disorder

Kim, Yourim; Kwon, Aeran; Min, Dongil; Kim, Sungkean; Jin, Min; Lee, Seung Hwan

doi:10.30773/pi.2019.07.28

Cited by 17 publications

(22 citation statements)

References 86 publications

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“…Deficits in social cognitive function are hallmarks of major psychiatric disorders, causing weakened social competence, impaired community functioning, and deterioration in quality of life (30,31). Relevant studies have investigated the impact of childhood trauma on social cognitive function (32)(33)(34). Our findings concur with the findings of Kilian, Asmal (17) that emotional neglect is negatively associated with social cognition within MCCB.…”

Section: Discussionsupporting

confidence: 89%

Association Between Cognitive Function and Early Life Experiences in Patients with Alcohol Use Disorder

et al. 2020

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Introduction: Early life experiences could be potential risk factors for the development of alcohol use disorder. In similar circumstances, it might also influence cognitive impairment in later life. However, the relationship between early life experience and cognitive function in people with alcohol use disorders is unclear. The current study examined the effects of early social environments and experiences on cognitive function in patients with alcohol use disorder. Methods: A total of 37 adult male patients with alcohol use disorder and 30 healthy control (HC) subjects were enrolled. The MATRICS Cognitive Consensus Battery (MCCB) was used to evaluate cognitive function. The Childhood Trauma Questionnaire (CTQ) and the Revised Adult Attachment Scale (RAAS) were used to evaluate early life experiences of the participants. The RAAS was used to evaluate the attachment patterns of participants. Results: Compared with the HC group, the alcohol use disorder group reported higher levels of childhood abuse and were more likely to form an insecure attachment style. Patients with alcohol use disorder who experienced trauma performed worse in terms of discrete cognitive parameters such as social cognition, reasoning and problem solving compared to patients without trauma. Importantly, emotional neglect and social comfort were significantly associated with individual social cognitive skills. Conclusions: Our results suggest that the cognitive function of patients with alcohol use disorder, especially social cognitive function, is affected by early life experiences.

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Section: Discussionsupporting

confidence: 89%

Association Between Cognitive Function and Early Life Experiences in Patients with Alcohol Use Disorder

et al. 2020

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“…All patients completed the 14-week intervention group, which is consistent with a high acceptability of the treatment strategy. Our study on CPEGT supports the concept that specific psychosocial interventions targeting specific aspects of BD can be beneficial (72,73).…”

Section: Discussionsupporting

confidence: 81%

Predictors of Functional Outcome in Patients With Bipolar Disorder: Effects of Cognitive Psychoeducational Group Therapy After 12 Months

et al. 2020

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Background: Cognitive deficits are known as a core feature in bipolar disorder. Persisting neurocognitive impairment is associated with low psychosocial functioning. The aim of this study was to identify potential cognitive, clinical and treatment-dependent predictors for functional impairment, symptom severity and early recurrence in bipolar patients, as well as to analyze neurocognitive performance compared to healthy controls.Methods: Forty three remitted bipolar patients and 40 healthy controls were assessed with a neurocognitive battery testing specifically attention, memory, verbal fluency and executive functions. In a randomized controlled trial, remitted patients were assigned to two treatment conditions as add-on to state-of-the-art pharmacotherapy: cognitive psychoeducational group therapy over 14 weeks or treatment-as-usual. At 12 months after therapy, functional impairment and severity of symptoms were assessed.Results: Compared to healthy controls, bipolar patients showed lower performance in executive function (perseverative errors p < 0.01, categories correct p < 0.001), sustained attention (total hits p < 0.001), verbal learning (delayed recall p < 0.001) and verbal fluency (p-words p < 0.002). Cognitive psychoeducational group therapy and attention predicted occupational functioning with a hit ratio of 87.5%. Verbal memory recall was found to be a predictor for symptom severity (hit ratio 86.8%). Recurrence in the follow-up period was predicted by premorbid IQ and by years of education (hit ratio 77.8%).Limitations: Limitations of the present study result mainly from a small sample size. The extent of cognitive impairment appears to impact occupational disability, clinical outcome as well as recurrence rate. This result must be interpreted with caution because statistical analysis failed to show higher significance.Conclusions: Bipolar patients benefit from cognitive psychoeducational group therapy in the domain of occupational life. Deficits in sustained attention have an impact on occupational impairment. Implications for treatment strategies are discussed. Further evaluation in larger studies is needed.

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“…For instance, Jauregui et al 80 found that patients with SCZ displayed abnormal decreases in both HF-HRV and LF-HRV in response to a variety of social cognition tasks, as compared to HCs and unaffected first degree relatives. Similarly, in a recent 2019 study, social functioning in SCZ was negatively associated with the LF/HF ratio, which represents less flexibility in autonomic functioning 81 . Per the theory of neurovisceral integration 6 , deficits in PFC functioning, which has been related to reduced HRV, may lead to disinhibition of the amygdala and cardioregulatory regions in the medulla, thereby leading to increased heart rate and decreased HRV in situations of social or emotion processing (Fig.…”

Section: Implications Of Autonomic Dysfunction In Sczmentioning

confidence: 79%

Autonomic nervous system dysfunction in schizophrenia: impact on cognitive and metabolic health

et al. 2021

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Schizophrenia (SCZ) is a psychiatric disorder characterized by a wide range of positive, negative and cognitive symptoms, along with an increased risk of metabolic syndrome and cardiovascular disease that contribute to a 15–20-year reduced life expectancy. Autonomic dysfunction, in the form of increased sympathetic activity and decreased parasympathetic activity, is postulated to be implicated in SCZ and its treatment. The aim of this narrative review is to view SCZ through an autonomic lens and synthesize the evidence relating autonomic dysfunction to different domains of SCZ. Using various methods of assessing autonomic activity, autonomic dysfunction was found to be associated with multiple aspects of SCZ pathophysiology, including symptom severity, cognitive impairment, and the development of cardiometabolic comorbidities, such as metabolic syndrome and high BMI. The strongest association of low heart rate variability was noted among patients on antipsychotic treatment with high-affinity muscarinic antagonism (i.e., clozapine, olanzapine and quetiapine). The review will also suggest ways in which studying autonomic dysfunction can help reduce morbidity and mortality associated with SCZ and its treatment.

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Neurophysiological and Psychological Predictors of Social Functioning in Patients with Schizophrenia and Bipolar Disorder

Cited by 17 publications

References 86 publications

Association Between Cognitive Function and Early Life Experiences in Patients with Alcohol Use Disorder

Association Between Cognitive Function and Early Life Experiences in Patients with Alcohol Use Disorder

Predictors of Functional Outcome in Patients With Bipolar Disorder: Effects of Cognitive Psychoeducational Group Therapy After 12 Months

Autonomic nervous system dysfunction in schizophrenia: impact on cognitive and metabolic health

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