Empfindlicher Nachweis von ?1-Foetoprotein im Serum durch passive H�magglutination

Abstract

Passive Haemagglutination: A Sensitive ~-Foetoprotein Assay.Sum,mary. Passive haemagglutination for c¢x-foetoprotein was carried out in the reverse system coupling an¢i-ccz-foetoprotein-IgG with bis-diazotized benzidine on sheep erythrocytes. The lowest concentration detectable in the serum was 30 ng/ml. All the sera of 26 unselected patients with primary]iver cell carcinoma showed titers of 1:32 or higher. Titers of >1:4 were found in 142 patients with other carcinomas with or without liver metastases in 28.2% and in 238 patients with other benign liver diseases in 10.5% to 23.8%. A negative result in passive haemagglutination seems to elimin~te the diagnosis of a hepatocellular cancer; titers between 1:4 and 1:256 occur in hepatomas and in other carcinomas as in benign liver diseases; titers of 1:512 or higher are typical for primary liver cell carcinoma. %-foetoprotein is not a ~umor antigen specific for primary liver cell carcinoma or teratoblastoma. Nevertheless, regarding the enormous difference in the concentration in controls, in patients with benign liver diseases, malignant tumors and primary liver cell carcinoma, it is a higlfly characteristic tumor antigen.

Early Detection of Hepatoma: Prospective Study in Liver Cirrhosis Using Passive Hemagglu‐tination and the Radioimmunoassay*

“…(7) Primary liver cell carcinoma is found to be more frequent in posthepatitic than in postalcoholic, cryptogenic, and other cirrhosis and to be more frequent in australia-antigen positive than in australia-antigen negative cases. (8) Routine serological tumor antigen screening of patients with a precancerous disease is useful.…”

Haemoglobins J in Canada

“…J Ox ford. Hopkins-2 and J Cambridge, is shown in table IV and suggests that Salomon el al., 1965Lehmann, 1974 their occurrence in the United Kingdom population is exceptional. It is therefore not surprising that none of these variants was amongst the Hbs J identified in Canadians of United Kingdom origin in this study.…”