Persistence of water-borne diseases in Dschang raises the question of drinking water management. The aim of this work was to establish a link between drinking water chain and its quality. Eighty-four water samples were followed and analyzed (membrane filter technique), from collection points, after transport, and then after 1 and 2 days of storage. A progressive degradation of water quality was observed regardless of the standing of the district and the type of container used. Salmonella species absent at the collection point were subsequently detected. After 2 days of storage, the highest rates were obtained in water collected with buckets in the water collection points of Madagascar, Gendarmerie, and Campus C Districts. The fecal coliform rate increased respectively in CFU/100 ml from 10 to 5100, 20 to 2333, and 10 to 953 and that of fecal streptococcus from 0 to 383, 6 to 380, and 4 to 125. The poor condition of the containers is indexed. This variation is partly responsible for the persistence of water-borne diseases in the town of Dschang.