The Department of Civil Protection (DPC), in compliance with the EU decision 1313/2013 and at the request of the Sendai Framework for Disaster Risk Reduction 2015–2030 to update the disaster risk assessments by various countries, released the latest National Risk Assessment for Italy at the end of 2018. Specifically, as regards the seismic risk assessment, six research units belonging to two centres of competence of the DPC collaborated under its guidance to update the risk maps of the Italian residential heritage. This extensive collaboration complied with the recent Italian code for Civil Protection, which requires a broad scientific consensus for risk assessment. During this research activity, six fragility models were developed, according to some common criteria (four for masonry buildings and two for RC buildings). These models were then implemented by the DPC for the definition of the national seismic risk. Within this context, the aim of this paper is to evaluate the risk results provided by these models, compare their features, and assess and validate their prediction capabilities. In particular, this paper shows the comparison of predicted and observed damage scenarios and consequences on building stock and the population of two seismic events, i.e. L’Aquila 2009 and Amatrice 2016. Furthermore, the paper provides some interesting damage and risk predictions at a national level. Overall, the forecasts and comparisons made in this study demonstrate the validity of the approach adopted by the DPC for the assessment of national seismic risk.