Employing an entropy-based measure of sway to probe postural stability in Fragile X Premutation carriers

OrKeeffe, Clodagh; Taboada, Laura P.; Feerick, Niamh; Gallagher, Louise; Lynch, Timothy; Reilly, Richard B.

doi:10.1109/ner.2019.8717071

Cited by 1 publication

(2 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There is a growing body of evidence describing subtle changes in motor behavior of younger Premutation Carriers before the typical age of onset of FXTAS. Several studies have described balance as a primary domain affected in younger carriers both when sensory input is challenged [4,5] and as cognitive load is increased [21][22][23]. In line with such studies, the classical sway parameters measured during this study suggest carriers exhibit reduced stability both when eyes were closed, and while engaged in cognitively strenuous tasks.…”

Section: Discussionsupporting

confidence: 85%

“…The cumulative pattern of the above results from these experiments and the dissociation between theta power and postural control observed in the premutation carrier group may indicate a disruption in the neural pathways that underpin error detection in postural stability. Future studies may benefit from employing more subtle measures of postural control such as entropy-based measures to assess changes in stability [21]. The sample size of this study is also limited, therefore, large scale, longitudinal, and age-matched studies would be needed to determine if this results from a stable developmental change resulting from the FMR1 premutation, or the beginning of neurodegenerative processes associated with FXTAS, however, the findings of the current research sheds new light on the neural correlates of postural control in younger fragile X Premutation Carriers and emphasizes the utility of temporally sensitive neuroimaging methods in characterizing these changes.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Decreased Theta Power Reflects Disruption in Postural Control Networks of Fragile X Premutation Carriers

O’Keeffe

Dominguez

O'Rourke

et al. 2020

2020 42nd Annual International Conference of the IEEE Engineering in Medicine &Amp; Biology Society (EMBC)

Self Cite

View full text Add to dashboard Cite

FRM1 premutation carriers exhibit various subtle deficits in balance and stability, prior to the development of the movement disorder Fragile X Associated Tremor/Ataxia Syndrome (FXTAS). Force plate posturography has increasingly been combined with the temporal sensitive imaging methods such as EEG to offer insight into the neural mechanisms which govern postural control. This study investigated cortical theta power during continuous balance and its relationship to balance performance in Fragile X premutation carriers. Eight premutation carriers and 6 controls stood on a force platform under altered sensory and cognitive conditions while postural sway and high-density EEG data were simultaneously recorded. Carriers exhibited greater sway area when sensory input was reduced (p=0.01) and cognitive load was increased (p=0.01), as well as significantly reduced frontal theta power compared to the Control Group. The relationship between theta power and postural control seen in the control group may indicate an increase in error detection caused by reduced visual input and greater discrepancies between expected and actual balance state. While the lower theta power in frontal regions of carriers may indicate a disruption in neural networks underpinning postural control. Such results provide new insight into the neural correlates of balance control in Fragile X premutation carriers.

show abstract