Employment trends in young women following a breast cancer diagnosis

Rosenberg, Shoshana M.; Vaz-Luís, Inês; Gong, Jingyi; Rajagopal, Padma Sheila; Ruddy, Kathryn J.; Tamimi, Rulla M.; Schapira, Lidia; Come, Steven E.; Borges, Virginia F.; Moor, Janet S. de; Partridge, Ann H.

doi:10.1007/s10549-019-05293-x

Cited by 25 publications

(12 citation statements)

References 30 publications

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“…The CANTO cohort allowed us to explore how body weight and employment trends are related in early stage BC survivors, who make up a relevant portion of the modern workforce. 13 In this large, prospective, contemporary cohort, we have shown that excess body weight at BC diagnosis is independently associated with increased rates of non-return-to-work 2 years afterwards, among young, previously employed BC survivors.…”

Section: Discussionmentioning

confidence: 82%

“…9 Randomised controlled trials have been conducted or are underway to evaluate the impact of weight loss interventions on BC recurrence and patients' QoL. 10 11 Although several factors have been previously identified that may negatively affect return to work after BC, including sociodemographic features, such as lower education level and income, 12 13 presence of concomitant medical problems, 14 psychological factors such as anxiety and depression, [15][16][17] higher disease burden, 13 more aggressive BC treatment modalities, 18 19 treatment-related side effects that lead to loss of functionality and reduced work capacity [15][16][17] as well as disadvantageous working conditions, 20 limited data are currently available on whether BMI at BC diagnosis and subsequent weight changes correlate with return to work among BC survivors.…”

Section: Key Questionsmentioning

confidence: 99%

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Body weight and return to work among survivors of early-stage breast cancer

et al. 2020

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BackgroundMany breast cancer (BC) survivors are employed at diagnosis and are expected to return to work after treatment. Among them, around 50% are overweight or obese. There are limited data about the impact of body weight on their ability to return to work.MethodsWe used data from CANcer TOxicity (NCT01993498), a prospective, multicentre cohort of women with stage I–III BC. Professionally active women who were ≥5 years younger than retirement age were identified. Multivariable logistic regression models examined associations of body mass index (BMI) at diagnosis and subsequent weight changes with non-return to work 2 years after diagnosis, adjusting for psychosocial, treatment and behavioural characteristics.ResultsAmong 1869 women, 689 were overweight or obese. Overall, 398 patients (21.3%) had not returned to work 2 years after diagnosis. Non-return to work was more likely for overweight or obese than underweight or normal weight patients (adjusted OR (aOR) 1.32; 95% CI, 1.01 to 1.75; p=0.045). Weight loss (≥5%) was observed in 15.7% overweight or obese and 8.7% underweight or normal weight patients and was associated with significant increases in physical activity only among overweight or obese patients (mean change, +4.7 metabolic-equivalent-of-task-hour/week; 95% CI +1.9 to +7.5). Overweight or obese patients who lost weight were more likely to return to work compared with those who did not lose weight (aOR of non-return-to-work, 0.48; 95% CI 0.24 to 0.97, p=0.0418), whereas weight loss was associated with increased odds of non-return to work among underweight or normal weight women (aOR 2.07; 95% CI 1.20 to 3.56, p=0.0086) (pinteractionBMI×weight changes=0.0002). The continuous trend of weight gain on non-return to work was significant for overweight or obese patients (aOR for one-percent-unit difference, 1.03; 95% CI 1.01 to 1.06, p=0.030).ConclusionsExcess weight may be a barrier to return to work. Among overweight or obese BC survivors, weight loss was associated with higher rates of return to work, whereas further weight gain was associated with lower likelihood of return to work. Employment outcomes should be evaluated in randomised studies of weight management.

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Section: Discussionmentioning

confidence: 82%

Section: Key Questionsmentioning

confidence: 99%

Body weight and return to work among survivors of early-stage breast cancer

et al. 2020

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“…In addition to the issue of survival, young women face other problems, including endocrine symptoms, anxiety, and unemployment. [ 20 , 21 ] In East Asian women, the incidence of breast cancer in younger patients is increased disproportionally compared with rates in American women. [ 12 ] There are few data providing survival outcomes in breast cancer patients younger than 30 years old.…”

Section: Discussionmentioning

confidence: 99%

The prognosis of early-stage breast cancer in extremely young female patients

Chung

Lee²,

Chen

et al. 2021

Medicine

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Breast cancer at a young age is associated with poor outcomes. However, few reports have compared the outcomes of breast cancer between extremely young patients and elderly patients. We retrospectively collected information on patients diagnosed with breast cancer before 30 years of age. This case-control study employed matched operative methods, stage, and subtypes with a case-to-control ratio of 1:3. The primary endpoint was disease-free survival, and the secondary endpoint was overall survival. We analyzed potential prognostic factors in univariate and multivariate analyses. This analysis included 18 patients in the young group with a median age of 28.5 years and 54 patients in the control group with a median age of 71 years. The 5-year disease-free survival rate was 68.8% in the former group and 84.6% in the latter group (P = .080). The 5-year overall survival was 87.1% and 91.2% in the young and old groups, respectively (P = .483). Multivariate analysis showed that tumor size and triple-negative breast cancer was major prognostic factors of poorer disease-free survival in the young group. Extremely young breast cancer patients had a trend to develop a poorer disease-free survival than old patients, but not a poorer overall survival. Aggressive treatment for young patients at early stages of disease would improve survival.

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“…44 Recent prospective data from the TAILORx trial with the use of the 21-gene recurrence score (RS) assay Oncotype DX are of particular relevance for premenopausal women. 45 In node-negative patients with hormone receptor-positive HER2-negative breast cancer and intermediate RS (11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25), the addition of chemotherapy to endocrine therapy did not show to provide any advantage in the overall breast cancer population. 46 However, the study showed that patients below 50 years of age and RS between 16 and 25 had apparent additional benefit with the use of adjuvant chemotherapy.…”

Section: Use Of Genomic Testsmentioning

confidence: 99%

“…Among them, genetic counseling, fertility preservation, impact on social and couple relationships, working life, and management of long-term side effects are crucial factors to be taken into account at the time of treatment planning. [14][15][16][17][18][19][20] Therefore, the care of premenopausal women with early breast cancer is particularly complex and a multidisciplinary approach is mandatory.…”

Section: Introductionmentioning

confidence: 99%

Current State of the Art in the Adjuvant Systemic Treatment of Premenopausal Patients With Early Breast Cancer

Parisi

Razeti

Blondeaux

et al. 2020

Clin Med Insights Oncol

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Breast cancer is the most frequent malignancy diagnosed in premenopausal women. In this age group, breast tumors tend to be diagnosed at more advanced stages and to harbor more aggressive biological features. In addition, specific age-related issues including genetic counseling, fertility preservation, impact on social and couple relationships, working life, and management of long-term side effects should be considered highly relevant when managing early breast cancer in premenopausal women. Therefore, the care of these patients is particularly complex and a multidisciplinary approach is mandatory. The present review summarizes the current state of art in the adjuvant systemic treatment of premenopausal women with early breast cancer focusing on the optimal chemotherapy, endocrine therapy, and targeted therapy approaches in this specific patient population.

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Employment trends in young women following a breast cancer diagnosis

Cited by 25 publications

References 30 publications

Body weight and return to work among survivors of early-stage breast cancer

Body weight and return to work among survivors of early-stage breast cancer

The prognosis of early-stage breast cancer in extremely young female patients

Current State of the Art in the Adjuvant Systemic Treatment of Premenopausal Patients With Early Breast Cancer

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