In the aftermath of spiritually transformative experiences (STEs—such as mystical experiences, near-death experiences, religious conversions, and kundalini awakenings), experiencers (STErs) have sometimes reported prolonged challenging integration processes. To date, there have not been any empirical studies of practices and approaches to addressing these struggles. The purpose of this study was to assess the extent to which practices STErs themselves utilized and found helpful. The Integration of Spiritually Transformative Experiences Inventory was created based on recommendations of 84 helpful practices proposed by four experienced clinicians. The 431 respondents were recruited through online STE networks and social media. Of those, 245 met criteria for integration as assessed by the 5-item Mental Health Inventory, and transformation as assessed by the Posttraumatic Growth Inventory-Short Form. Participants rated 80 of the 84 practices as helpful. Twelve practices were rated by all participants as essential (4.0 on a Likert scale of 1–4) including (a) practicing compassion, forgiveness, gratitude, and self-awareness; (b) exploring the unconscious; (c) finding serene environments; and (d) reading spiritual literature, praying, and sharing with another person. A key finding was that across a variety of STEs, there were high levels of agreement regarding the integration practices rated as helpful, and that psychiatric care and medication were usually not reported to be helpful (p < .001). The correlation between helpfulness and frequency of use showed that STErs gravitated intuitively to what was the most useful for them (p < .0001). Findings offer guidance for STErs themselves and the health care providers who serve them.