Emu oil based nano-emulgel for topical delivery of curcumin

Jeengar, Manish Kumar; Rompicharla, Sri Vishnu Kiran; Shrivastava, Shweta; Chella, Naveen; Shastri, Nalini R.; Naidu, V.G.M.; Sistla, Ramakrishna

doi:10.1016/j.ijpharm.2016.04.052

Cited by 89 publications

(38 citation statements)

References 59 publications

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“…Protein lyaste were prepared as described previously 41 . Briefly, Colon tissue was homogenized in RIPA buffer with 1% protease and phoshphatase inhibitor cocktail (Sigma-Aldrich, St. Louis, MO, USA) and incubated on ice for 1 h. Lysates were then centrifuged for 15 min at 13000 rpm at 4 °C.…”

Section: Discussionmentioning

confidence: 99%

Uridine Ameliorates Dextran Sulfate Sodium (DSS)-Induced Colitis in Mice

Jeengar

Thummuri

Magnusson

et al. 2017

Sci Rep

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Uridine, one of the four components that comprise RNA, has attracted attention as a novel therapeutic modulator of inflammation. However, very little is known about its effect on intestinal inflammation. The aim of the present study was to investigate the potential protective effect of intracolonic administered uridine against DSS induced colitis in male C57BL/6 mice. Intracolonic instillation of 3 doses of uridine 1 mg/Kg (lower dose), 5 mg/Kg (medium dose), and 10 mg/Kg (higher dose) in saline was performed daily. Uridine at medium and high dose significantly reduced the severity of colitis (DAI score) and alleviated the macroscopic and microscopic signs of the disease. The levels of proinflammatory cytokines IL-6, IL-1β and TNF in serum as well as mRNA expression in colon were significantly reduced in the uridine treated groups. Moreover, colon tissue myloperoxidase activities, protein expression of IL-6, TNF- α, COX-2, P-NFkB and P-Ikk-βα in the colon tissues were significantly reduced in medium and high dose groups. These findings demonstrated that local administration of uridine alleviated experimental colitis in male C57BL/6 mice accompanied by the inhibition of neutrophil infiltration and NF-κB signaling. Thus, Uridine may be a promising candidate for future use in the treatment of inflammatory bowel disease.

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Section: Discussionmentioning

confidence: 99%

Uridine Ameliorates Dextran Sulfate Sodium (DSS)-Induced Colitis in Mice

Jeengar

Thummuri

Magnusson

et al. 2017

Sci Rep

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“…The antiinflammatory arthritic scoring, paw volume, biochemical, molecular, radiological, and histological tests showed important improvements in anti-inflammatory activity with formulations containing curcumin in combination with emu oil compared to pure curcumin. 66 The environment friendly synthesis of biodegradable semiinterpenetrating hydrogel networks using N,N′-methylenebis(acrylamide) (MBA) and carboxymethylcellulose has been performed. Then, AgNPs supported on hydrogel networks as nanoreactors have used AgNO 3 and Azadirachta indica (Neem) plant extracts under ambient conditions by green chemistry methods.…”

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confidence: 99%

A review of drug delivery systems based on nanotechnology and green chemistry: green nanomedicine

Jahangirian

Lemraski

Webster

et al. 2017

IJN

451

216

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This review discusses the impact of green and environmentally safe chemistry on the field of nanotechnology-driven drug delivery in a new field termed “green nanomedicine”. Studies have shown that among many examples of green nanotechnology-driven drug delivery systems, those receiving the greatest amount of attention include nanometal particles, polymers, and biological materials. Furthermore, green nanodrug delivery systems based on environmentally safe chemical reactions or using natural biomaterials (such as plant extracts and microorganisms) are now producing innovative materials revolutionizing the field. In this review, the use of green chemistry design, synthesis, and application principles and eco-friendly synthesis techniques with low side effects are discussed. The review ends with a description of key future efforts that must ensue for this field to continue to grow.

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“…Another investigation was designed to evaluate the antiinflammatory potential of Cur in combination with emu oil from a nanoemulgel formulation in experimental inflammation and arthritic in vivo models. They found that the nanoemulgel showed a significant improvement in antiinflammatory activity 78. Arora et al synthesized the Cur‐loaded SLNs (C‐SLNs) system, finding that the drug can ameliorate complete Freund's adjuvant (CFA)‐induced arthritis in rats through attenuation of oxido‐inflammatory and immunomodulatory cascade, significantly improved biochemical markers and preserved radiological alterations in joints of arthritic rats 52.…”

Section: Nanotherapeutics Of Ra Based On Nanodrugsmentioning

confidence: 99%

Recent Advances in Nanotheranostics for Treat‐to‐Target of Rheumatoid Arthritis

Wang

Meng

et al. 2020

Adv Healthcare Materials

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Early diagnosis, standardized treatment, and regular monitoring are the clinical treatment principle of rheumatoid arthritis (RA). The overarching principles and recommendations of treat‐to‐target (T2T) in RA advocate remission as the optimum aim, especially for patients with very early disease who are initiating therapy with anti‐RA medications. However, traditional anti‐RA drugs cannot selectively target the inflammatory areas and may cause serious side effects due to its short biological half‐life and poor bioavailability. These limitations have significantly driven the research and application of nanomaterial‐based drugs in theranostics of RA. Nanomedicines have appropriate sizes and easily modified surfaces which can enhance their biological compatibility and prolong circulation time of drug‐loading systems in vivo. Traditional T2T regimens cannot evaluate the efficacy of drugs in real time, while clinical drug nanosizing can realize the integration of diagnosis and treatment of RA. This review bridges clinically proposed T2T concepts and nanomedicine in an integrated system for RA early‐stage diagnosis and treatment. The most advanced progress in various nanodrug delivery systems for theranostics of RA is summarized, establishing a clear path and a new perspective for further optimization of T2T. Finally, the key facing challenges are discussed and prospects are addressed.

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Emu oil based nano-emulgel for topical delivery of curcumin

Cited by 89 publications

References 59 publications

Uridine Ameliorates Dextran Sulfate Sodium (DSS)-Induced Colitis in Mice

Uridine Ameliorates Dextran Sulfate Sodium (DSS)-Induced Colitis in Mice

A review of drug delivery systems based on nanotechnology and green chemistry: green nanomedicine

Recent Advances in Nanotheranostics for Treat‐to‐Target of Rheumatoid Arthritis

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