Emulsion‐Assisted Polymerization‐Induced Hierarchical Self‐Assembly of Giant Sea Urchin‐like Aggregates on a Large Scale

Xu, Qingsong; Huang, Tong; Li, Shanlong; Li, Ké; Li, Chuanlong; Liu, Yannan; Wang, Yuling; Yu, Chunyang; Zhou, Yongfeng

doi:10.1002/ange.201802833

Cited by 22 publications

(16 citation statements)

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“…reported a facile method to synthesize ACPs by the robust, efficient, and orthogonal click chemistry under mild reaction conditions . Our group also synthesized a serial of amphiphilic ACPs through the click reactions of amine-epoxy/amine-thiol and the obtained ACPs could self-assemble into various architectures, such as nanotubes, vesicles, and sea urchin like assemblies . In addition, some of them were used as electrode materials. , Thus, we want to use this facile method of thiol-epoxy/amine-epoxy click reactions to further design and synthesize ACPs with excellent biocompatibility and stimulus-responsive properties for biomedical applications.…”

Section: Introductionmentioning

confidence: 99%

Facile Synthesis of a H₂O₂-Responsive Alternating Copolymer Bearing Thioether Side Groups for Drug Delivery and Controlled Release

Wang

Huang

et al. 2019

ACS Omega

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A novel amphiphilic alternating copolymer with thioether side groups (P(MSPA-a-EG)) was synthesized through an amine-epoxy click reaction of 3-(methylthio)propylamine (MSPA) and ethylene glycol diglycidyl ether. P(MSPA-a-EG) was characterized in detail by nuclear magnetic resonance (NMR), gel permeation chromatography, Fourier transformed infrared, differential scanning calorimeter, and thermogravimetric analysis to confirm the successful synthesis. Due to its amphiphilic structure, P(MSPA-a-EG) could self-assemble into spherical micelles with an average diameter of about 151 nm. As triggered by H2O2, theses micelles could disassemble because hydrophobic thioether groups are transformed to hydrophilic sulfoxide groups in MSPA units. The oxidant disassemble process of micelles was systemically studied by dynamic light scattering, transmission electron microscopy, and 1H NMR measurements. The MTT assay against NIH/3T3 cells indicated that P(MSPA-a-EG) micelles exhibited good biocompatibility. Furthermore, they could be used as smart drug carriers to encapsulate hydrophobic anticancer drug doxorubicin (DOX) with 4.90% drug loading content and 9.81% drug loading efficiency. In vitro evaluation results indicated that the loaded DOX could be released rapidly, triggered by H2O2. Therefore, such a novel alternating copolymer was expected to be promising candidates for controlled drug delivery and release.

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Section: Introductionmentioning

confidence: 99%

Facile Synthesis of a H₂O₂-Responsive Alternating Copolymer Bearing Thioether Side Groups for Drug Delivery and Controlled Release

Wang

Huang

et al. 2019

ACS Omega

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“…Meanwhile, the reaction media of PISA can be water, alcohol and nonpolar solvents, which have been extensively investigated by Armes [ 110 ], Boyer [ 111 ], Charleux [ 112 ], Pan [ 113 ], An [ 114 ], and others [ 115 , 116 , 117 ]. For examples, Zhou et al reported that PISA strategy, with the advantages of in situ self-assembly, scalable preparation, and facile functionalization, can be used to prepare hierarchical multiscale sea urchin-like assemblies, taking advantage of epoxy thiol click polymerization [ 118 ]. The PISA process enables the effective preparation of nanostructures with varies morphologies starting with a single initial solvophilic homopolymer and extend the chain via one-pot reactions.…”

Section: Basic Concepts Related To Supramolecular Chiralitymentioning

confidence: 99%

Supramolecular Chirality in Azobenzene-Containing Polymer System: Traditional Postpolymerization Self-Assembly Versus In Situ Supramolecular Self-Assembly Strategy

Cheng

Miao

Qian

et al. 2020

IJMS

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Recently, the design of novel supramolecular chiral materials has received a great deal of attention due to rapid developments in the fields of supramolecular chemistry and molecular self-assembly. Supramolecular chirality has been widely introduced to polymers containing photoresponsive azobenzene groups. On the one hand, supramolecular chiral structures of azobenzene-containing polymers (Azo-polymers) can be produced by nonsymmetric arrangement of Azo units through noncovalent interactions. On the other hand, the reversibility of the photoisomerization also allows for the control of the supramolecular organization of the Azo moieties within polymer structures. The construction of supramolecular chirality in Azo-polymeric self-assembled system is highly important for further developments in this field from both academic and practical points of view. The postpolymerization self-assembly strategy is one of the traditional strategies for mainly constructing supramolecular chirality in Azo-polymers. The in situ supramolecular self-assembly mediated by polymerization-induced self-assembly (PISA) is a facile one-pot approach for the construction of well-defined supramolecular chirality during polymerization process. In this review, we focus on a discussion of supramolecular chirality of Azo-polymer systems constructed by traditional postpolymerization self-assembly and PISA-mediated in situ supramolecular self-assembly. Furthermore, we will also summarize the basic concepts, seminal studies, recent trends, and perspectives in the constructions and applications of supramolecular chirality based on Azo-polymers with the hope to advance the development of supramolecular chirality in chemistry.

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“…The average wall thickness of the hollow polymeric spheres measures 87 ± 35 nm. It was found in the previous studies that alternating copolymers could self-assemble into various ordered nanostructures, including nanotubes, 29 sea urchin-like self-assemblies, 30 nanospheres, 31 and vesicles. 32,33 To the best of our knowledge, the hollow spheres observed in this work represent the first example in the self-assembly of alternating copolymers.…”

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confidence: 99%

“…Self-assembly of amphiphilic copolymers in solution has been considered as a versatile approach for the preparation of various ordered nanostructures. − Among different types of polymer precursors, alternating copolymers exhibit a unique alternating monomeric unit structure in the backbone. This allows the self-assembly of alternating copolymers into nanostructures with hydrophobic or hydrophilic domains of uniform dimension in spite of the dispersity of the copolymers. − By taking advantage of the peculiarity of alternating copolymers, we developed the first template-free method toward porous HCSs with uniform micropores in the wall, by the self-assembly of an amphiphilic alternating copolymer in solution (Figure ). Driven by hydrophobic, π–π, and H-bonding interactions, the alternating copolymer, P(BGF- a -DHBDT), self-assembled into HPSs of narrow size distribution in a solvent mixture of DMF and H 2 O.…”

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confidence: 99%

Solution Self-Assembly of an Alternating Copolymer toward Hollow Carbon Nanospheres with Uniform Micropores

Rasheed

Tian

et al. 2019

ACS Macro Lett.

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Controllable preparation of porous hollow carbon spheres (HCSs) has attracted considerable attention due to their potential applications, e.g., in energy conversion and storage. We report for the first time the synthesis of narrowly size-distributed HCSs with uniform micropores in the wall, through a simple template-free approach, which employs the solution self-assembly of an alternating copolymer (poly(9,9′-bis(4-glycidyloxyphenyl)fluorene-alt-2,3-dihydroxy-butylene dithioether) (P(BGF-a-DHBDT))). This alternating copolymer first self-assembled into previously undocumented hollow polymeric spheres (HPSs) in an N,N-dimethylformamide (DMF)/H2O solvent mixture. After the cross-linking of the BGF segments in the spheres, the stabilized HPSs (CL-HPSs) were carbonized at 800 °C under N2 atmosphere, yielding porous HCSs with uniform micropores of very narrow size distribution (0.4–0.8 nm) in the wall, benefiting from the uniform DHBDT block length in the alternating copolymer. Through KOH activation, which made the internal pores fully interconnected, uniform micropores (0.5–1.0 nm) of a narrow size distribution were retained within the activated HCSs (A-HCSs), while their specific surface areas (SSAs) were much increased to 2580 m2 g–1. As a proof of concept, the A-HCSs were applied as electrode materials of supercapacitors. They exhibited superior electrochemical performance with a high specific capacitance (292 F g–1 at 0.2 A g–1), good rate capability, and outstanding cycling stability with no apparent capacitance loss after 10 000 cycles.

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Emulsion‐Assisted Polymerization‐Induced Hierarchical Self‐Assembly of Giant Sea Urchin‐like Aggregates on a Large Scale

Cited by 22 publications

References 57 publications

Facile Synthesis of a H₂O₂-Responsive Alternating Copolymer Bearing Thioether Side Groups for Drug Delivery and Controlled Release

Facile Synthesis of a H₂O₂-Responsive Alternating Copolymer Bearing Thioether Side Groups for Drug Delivery and Controlled Release

Supramolecular Chirality in Azobenzene-Containing Polymer System: Traditional Postpolymerization Self-Assembly Versus In Situ Supramolecular Self-Assembly Strategy

Solution Self-Assembly of an Alternating Copolymer toward Hollow Carbon Nanospheres with Uniform Micropores

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Emulsion‐Assisted Polymerization‐Induced Hierarchical Self‐Assembly of Giant Sea Urchin‐like Aggregates on a Large Scale

Cited by 22 publications

References 57 publications

Facile Synthesis of a H2O2-Responsive Alternating Copolymer Bearing Thioether Side Groups for Drug Delivery and Controlled Release

Facile Synthesis of a H2O2-Responsive Alternating Copolymer Bearing Thioether Side Groups for Drug Delivery and Controlled Release

Supramolecular Chirality in Azobenzene-Containing Polymer System: Traditional Postpolymerization Self-Assembly Versus In Situ Supramolecular Self-Assembly Strategy

Solution Self-Assembly of an Alternating Copolymer toward Hollow Carbon Nanospheres with Uniform Micropores

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Facile Synthesis of a H₂O₂-Responsive Alternating Copolymer Bearing Thioether Side Groups for Drug Delivery and Controlled Release

Facile Synthesis of a H₂O₂-Responsive Alternating Copolymer Bearing Thioether Side Groups for Drug Delivery and Controlled Release