Emulsion of Chloramphenicol: an Overwhelming Approach for Ocular Delivery

Ashara, Kalpesh Chhotalal; Shah, Ketul

doi:10.1515/folmed-2017-0007

Cited by 8 publications

(3 citation statements)

References 10 publications

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“…The most points of interest related with w/o sort emulsion is spontaneous arrangement and thermodynamically soundness [13]. It has been utilized for the conveyance of certain drugs like dexamethasone, tobramycin [14], chloramphenicol [15] Bicontineous lipid emulsion: In this sort of emulsion, oil and water both exist in continues phase so called as bicontinuous emulsion. The rheological property exhibits non-newtonian stream.…”

Section: Water In Oil (W/o) Lipid Emulsionmentioning

confidence: 99%

A Review of Potential Effect of Nanotechnology and Control Drug Delivery System Introduce Into Ocular Drug Delivery System

Das¹,

Sharma²,

Chandrul³

2019

IJTSRD

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Nanotechnology is a positive concept which will soon improved the field of medical science and technology. In this process used nano meters to penetrate and has improved the medicine and avenues of science. The various types of eye diseases will treated by this nanotechnology, and also enhance the positive effect of the medicated dose. Various aspect of treatment and diagnosis in eye disease are expected to be in future. It will not improved our approach to current therapeutic challenges, but enable to address currently unsolved problems Nanotechnology is the conducted to special treatment process to minimized the drug adverse effect and their accurate dosage form. The technology is being explore as a means of drug delivery, not only the systemic medication, but also for ocular application as many of the condition.

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Section: Water In Oil (W/o) Lipid Emulsionmentioning

confidence: 99%

A Review of Potential Effect of Nanotechnology and Control Drug Delivery System Introduce Into Ocular Drug Delivery System

Das¹,

Sharma²,

Chandrul³

2019

IJTSRD

View full text Add to dashboard Cite

show abstract

“…The main advantages associated with w/o type emulsion is spontaneous formation and thermodynamically stability [13]. It has been used for the delivery of certain drugs like dexamethasone, tobramycin [14], chloramphenicol [15].…”

Section: Water-in-oil (W/o) Lipid Emulsionmentioning

confidence: 99%

Therapeutic challenges in ocular delivery of lipid based emulsion

Tiwari

Pandey

Asati

et al. 2018

Egyptian Journal of Basic and Applied Sciences

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In the last decade, lipid based emulsions (LEs) have emerged as a novel tool in ophthalmic drug delivery from the aspect of improved bioavailability (BA). Recent research is focuses on two main approaches for BA improvement i.e., by enhancing the corneal permeability and increasing the retention time of drug on the ocular surface. The LEs have great potential to delivery hydrophobic drug because drug molecules get dissolve in oil globule and main advantage associated are reduced toxic effect and improved self-life of drug molecule. Ophthalmic drug delivery is always an interesting and challenging task for the pharmacologists and formulation scientists due to the unique structure of eye. Development of drug delivery system and its delivery to target receptor of the eye is very difficult for scientists due to the strong defense mechanism of eye. In this review, the focus is to explore key concepts of ophthalmic drug delivery with emphasis on the defense mechanisms, design considerations, and safety assessment of LEs for the ocular drug delivery.

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“…4 Allergic conjunctivitis if not managed in time leads to compromised over all quality of life of individual. 5,6 Topical antihistamines and mast cell stabilizers have been main stay of treatment for allergic conjunctivitis. 7 Agents with dual mechanism of action i.e.…”

Section: Introductionmentioning

confidence: 99%

Therapeutic Efficacy of Topical Olopatadine 0.1% Versus Ketotifen Fumarate in Allergic Conjunctivitis

Abidin

Sarfraz²,

Javaid³

et al. 2022

PAFMJ

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Objective: To compare the therapeutic efficacy of topical Olopatadine 0.1% versus Ketotifen Fumarate among the patients diagnosed with allergic conjunctivitis at Armed forces institute of ophthalmology. Study Design: Prospective comparative study. Place and Duration of Study: Armed forces Institute of Ophthalmology, Rawalpindi, from Jan 2020 to Jan 2021. Methodology: Patients diagnosed with allergic conjunctivitis by consultant ophthalmologist fulfilling the exclusion/inclusion criteria were included in the study. They were divided into two groups by block randomization with group A receiving Olopatadine 0.1%, while group B just received the Ketotifen Fumarate. Symptoms were assessed on a symptom severity score upon diagnosis before the start of medication and then after 72 hours of treatment by a different consultant ophthalmologist who was unaware of the group of patients. Results: A total of 100 patients were included in each group. The mean age of the study participants was 30.944 ± 3.349 years. 148 (74%) patients were males while 52 (26%) were females. The difference in mean score of symptoms in group A was 5.76 ± 1.39 while in group B was 3.33 ± 2.51. Application of t-test revealed that topical Olopatadine 0.1% was superior to Ketotifen Fumarate in reducing the symptoms of acute allergic conjunctivitis on the third day of treatment (p-value<0.001). Conclusion: Seasonal allergic conjunctivitis was the commonest type of allergic conjunctivitis seen in our study participants. Topical Olopatadine 0.1% emerged as a better treatment option when compared to Ketotifen Fumarate for immediate management of acute allergic conjunctivitis among patients managed at a tertiary...................

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Emulsion of Chloramphenicol: an Overwhelming Approach for Ocular Delivery

Abstract: The optimized batch of an emulsion of chloramphenicol was found to be as safe as and more effective than Chloramphenicol eye caps.

Cited by 8 publications

References 10 publications

A Review of Potential Effect of Nanotechnology and Control Drug Delivery System Introduce Into Ocular Drug Delivery System

A Review of Potential Effect of Nanotechnology and Control Drug Delivery System Introduce Into Ocular Drug Delivery System

Therapeutic challenges in ocular delivery of lipid based emulsion

Therapeutic Efficacy of Topical Olopatadine 0.1% Versus Ketotifen Fumarate in Allergic Conjunctivitis

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