Emulsiones lipídicas en la intoxicación por anestésicos locales y otros fármacos. Revisión sobre mecanismos de acción y recomendaciones de uso

García-Ramos, S.E.; Fernández, Ignacio; Zaballos, M.

doi:10.1016/j.redar.2021.03.012

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2024

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“…This observation suggests the ability of lipid-rich plasma to draw a lipophilic molecule 11. ILE may also act via ‘lipid shuttle’, a mechanism according to which a lipid emulsion can absorb lipophilic molecules and transport them from highly perfused organs to the liver and muscles where detoxification and storage may occur 12 13…”

Section: Discussionmentioning

confidence: 99%

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Intravenous lipid emulsion for a life-threatening prothipendyl intoxication

Meunier,

Goffin,

Deville

et al. 2024

BMJ Case Rep

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Prothipendyl, a lipophilic neuroleptic drug, requires a careful dosage regimen due to its potential side effects, including life-threatening arrhythmias.This report outlines a case of severe prothipendyl intoxication, its management and the successful utilisation of Intralipid, an intravenous lipid emulsion, in treating ventricular arrhythmia postmassive prothipendyl ingestion. Additionally, the mechanism of action of Intralipid and the rebound concentration of the lipophilic drug in such scenarios are discussed.

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Section: Discussionmentioning

confidence: 99%

“…If the instability persists, two extra boluses of 1.5 mL/kg may be considered and the infusion rate may be increased up to 30 mL/kg/hour 14. ILE might be considered in case of severe cardiovascular instability due to a lipophilic drug intoxication when conventional measures fail 12 15 16…”

Section: Discussionmentioning

confidence: 99%