Today, Big Data, IoT and Analytics are driving and making the differences in key performing top organizations. The interplay of these three areas can be instrumental for the future development of research, complex systems and enterprises. IoT will be estimated to rise to billions of devices connected by 2020 [1]. This has huge implications for research, businesses and future activities for mankind. The development of this vision is pivotal to support and foster IoTBDS (iotbds.org). Sensors are used to extract an unprecedented amount of data, which can be filtered and processed in the IoT by machine networks, automated analysis, tools and systems. This can become a Big Data layer abstraction from the captured data if the process is well-organized. Hereby, complex information systems can obtain the benefits of collecting, processing and analyzing highly valuable data. This is one of the most important scopes of COM-PLEXIS (complexis.org). Therefore, starting from the pillars of IoT, Analytics and Big Data, we can build complex information architectures by using tools like social media, predictive modeling, insight analysis and sentiment analysis. Eventually, we can build three additional layers: complex data, information and knowledge, and offer service related to these three valued-added layers. The application fields are widespread in fields like social networking, financial services, or biological research.This special issue (SI) call is focused on contributions that explore and demonstrate related areas, approaches and recommendations for both IoTBDS and COMPLEXIS. In particular, research work and projects that offer solutions to the underlying prob-B Victor Chang