Enantioanalysis of (-)Butaclamol Using Vancomycin and Teicoplanin as Chiral Selectors

Abstract

Butaclamol is an antipsychotic drug used in the treatment of schizophrenia. The macrocyclic antibiotics, vancomycin and teicoplanin, are proposed as chiral selectors for the design of the enantioselective, potentiometric membrane electrodes (EPMEs) for the assay of (-)butaclamol. The slopes of the electrodes are near-Nernstian for the assay of (-) butaclamol with linear concentration ranges between 10(-10) and 10(-7) mol/L and between 10(-9) and 10(-7) mol/L for vancomycin and teicoplanin based EPMEs. Limits of detections varied. The electrodes were used reliably for the enantioanalysis of (-) butaclamol in serum samples.

An Enantioselective Potentiometric Sensor for 2-Amino-1-Butanol Based on Chiral Porous Organic Cage CC3-R

“…Although these methods have different advantages in terms of sensitivity or applicability, they suffer similar drawbacks including complicated operation and the need for expensive equipment. By contrast, ion-selective electrodes are simple, rapid and affordable, and have been widely applied to the enantioselective recognition and detection of chiral compounds in recent years [1,2,3,4,5,6,7,8,9].…”

A chiral, porous, organic cage‐based, enantioselective potentiometric sensor for 2‐aminobutanol

“…2 Although there are many chiral separation and analysis technologies with high precision and accuracy, most of the instruments are very expensive; the operations are very complicated and difficult to use for real-time analysis. Recently, the ion-selective electrode (ISE) was introduced for the determination of optically active compounds, [3][4][5][6][7][8][9][10][11][12][13][14] offering some advantages such as low cost, simple equipment, and high sensitivity.…”