Organic Syntheses 2003
DOI: 10.1002/0471264180.os069.02
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Enantiomerically Pure Ethyl ( R )‐ and ( S )‐ 2‐Fluorohexanoate by Enzyme‐Catalyzed Kinetic Resolution

Abstract: Enantiomerically pure ethyl ( R )‐ and ( S )‐ 2‐fluorohexanoate by enzyme‐catalyzed kinetic resolution product: ethyl 2‐fluorohexanoate product: ethyl (R)‐2‐fluorohexanoate intermediate: (S)‐2‐fluorohexanoic acid product: 28.4 g (0.175 mol) of ethyl (S)‐2‐fluorohexanoate (81% ee)

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