Enantioselective Alkynylations of Aromatic and Aliphatic Aldehydes Catalyzed by Terpene Derived Chiral Amino Alcohols.

Abstract

Enantioselective syntheses O 0031Enantioselective Alkynylations of Aromatic and Aliphatic Aldehydes Catalyzed by Terpene Derived Chiral Amino Alcohols. -A homochiral limonene-derived amino alcohol catalyzes the title reaction to give the desired propargylic alcohols in good yields and moderate enantiomeric excesses (14 examples). -(WATTS, C. C.; THONIYOT, P.; HIRAYAMA, L. C.; ROMANO, T.; SINGARAM*, B.; Tetrahedron: Asymmetry 16 (2005) 10, 1829-1835;