Enantioselective and Enantiospecific Transition-Metal-Catalyzed Cross-Coupling Reactions of Organometallic Reagents To Construct C–C Bonds

Enantioconvergent Fukuyama Cross‐Coupling of Racemic Benzylic Organozinc Reagents

“…[7] Up to now,o nly one nickelcatalyzed example of such ar eaction is known. [8] We hypothesized that rapid equilibration between the two enantiomers of aracemic secondary organometallic reagent [9] could enable an appropriate chiral catalyst to react preferentially with one enantiomer by ad ynamic kinetic resolution (DKR;S cheme 1c).…”

Zirconocene catalyzed diastereoselective carbometalation of cyclobutenes

“…Would the resulting cyclobutylcopper species be produced with retention 18 or inversion 19 of configuration and would it also present some configurational stability? Thus, to the intermediate VIII , prepared as previously described from 1a with ZrCp 2 Cl 2 (20 mol%) and ethylmagnesium bromide, the corresponding cyclobutylcopper species was obtained by addition of CuI and LiCl (10 and 20 mol% respectively) at 0 °C for 15 min.…”

Nickel-Catalyzed Cross-Coupling Reactions of Unreactive Phenolic Electrophiles via C–O Bond Activation

“…Cross-coupling reactions of inert phenol derivatives by other transition metal catalysts, such as Ru [6][7][8][9][10], Fe [11,12], Co [13], Rh [14,15] and Cr [16], are beyond the scope of this review. Catalytic transformations via alkenyl [17][18][19][20][21][22][23][24][25][26][27][28] and benzylic C-O bond [29,30] activation are not covered. In addition, readers are encouraged to consult previous reviews on catalytic C-O bond activation reactions [31][32][33][34][35][36][37][38].…”