Enantioselective determination of a gastroprokinetic drug using amylose tris-(3,5-dimethylphenylcarbamate) as a stationary phase by HPLC

Rao, R. Nageswara; Nagaraju, D.; Narasaraju, A.

doi:10.1016/j.jpba.2005.08.003

Cited by 8 publications

(1 citation statement)

References 19 publications

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“…High-performance liquid chromatography (HPLC) with UV detection was used to determine mosapride in bulk drugs or pharmaceutical preparations [13][14][15]. The enantioseparation and enantioselective determination by HPLC with UV detection [16,17] or HPLC with fluorometric detection [18] were also reported. Pharmacokinetic profiles of mosapride in rats [19], dogs, monkeys [20], and healthy human subjects [21] have been well characterized by HPLC with UV detection.…”

Section: Introductionmentioning

confidence: 99%

Liquid chromatography–tandem mass spectrometric method for determination of mosapride citrate in equine tissues

Aoki¹,

Hakamata

Igarashi³

et al. 2007

Journal of Chromatography B

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Section: Introductionmentioning

confidence: 99%

Liquid chromatography–tandem mass spectrometric method for determination of mosapride citrate in equine tissues

Aoki¹,

Hakamata

Igarashi³

et al. 2007

Journal of Chromatography B

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HPLC‐fluorescence assay for measuring mosapride in small volumes of rat plasma

Cheng

Chang

Chou

2009

Biomedical Chromatography

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A simple and sensitive HPLC-fluorescence assay was developed for the determination of a gastroprokinetic agent mosapride in small volumes of rat plasma. Samples (50 microL) were treated with 200 microL of the internal standard solution (cisapride, 0.1 microg/mL in acetonitrile). Chromatographic separation was achieved on a C(18) column by gradient elution with the mobile phase of acetonitrile-water containing 20 mM potassium dihydrogen phosphate, at a flow rate of 1 mL/min. Fluorescence was measured with excitation and emission set at 315 and 354 nm, respectively. The retention time was about 16 min for cisapride and 20 min for mosapride. No endogenous substances were found to interfere. The calibration curve was linear from 0.015 to 10 microg/mL. The lower limit of quantification was 0.015 microg/mL. The intra- and inter-day precision expressed as relative standard deviation did not exceed 7.7%, and the accuracy was within 4.7% deviation of the nominal concentration. The method was used successfully to investigate the disposition kinetics of mosapride in rats.

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Preparation and chiral recognition of new chiral stationary phases derived from cellulose microspheres

Jin

Zhang

Chen

et al. 2012

Wuhan Univ. J. Nat. Sci.

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Enantioselective determination of a gastroprokinetic drug using amylose tris-(3,5-dimethylphenylcarbamate) as a stationary phase by HPLC

Cited by 8 publications

References 19 publications

Liquid chromatography–tandem mass spectrometric method for determination of mosapride citrate in equine tissues

Liquid chromatography–tandem mass spectrometric method for determination of mosapride citrate in equine tissues

HPLC‐fluorescence assay for measuring mosapride in small volumes of rat plasma

Preparation and chiral recognition of new chiral stationary phases derived from cellulose microspheres

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