Enantioselective extraction of fenvaleric acid enantiomers by two-phase (W/O) recognition chiral extraction

Enantioseparation of Racemic Flurbiprofen by Aqueous Two‐Phase Extraction With Binary Chiral Selectors of L‐dioctyl Tartrate and L‐tryptophan

“…A variety of chiral selectors such as crown ether, porphyrin, tartaric acid derivatives, cyclodextrins and their derivatives, etc., were selected as chiral selectors in ELLE . Nevertheless, the application of many current chiral selectors is often limited to their solubility for many solvents . The enantioselectivity of monophasic recognition extraction is relatively low with a chiral selector, whereas biphasic recognition chiral extraction (BRCE) can greatly improve the enantioselectivity by the cooperation of both the separation abilities of hydrophobic and hydrophilic chiral selectors.…”

“…The enantioselectivity of monophasic recognition extraction is relatively low with a chiral selector, whereas biphasic recognition chiral extraction (BRCE) can greatly improve the enantioselectivity by the cooperation of both the separation abilities of hydrophobic and hydrophilic chiral selectors. The combination of two chiral selectors enables forming hydrophobic and hydrophilic complexes with specific enantiomers and then being extracted into organic and aqueous phases, respectively . The key to successful separation is whether chiral selectors match target enantiomers in the reaction extraction.…”

“…The key to successful separation is whether chiral selectors match target enantiomers in the reaction extraction. For example, tartaric esters and β‐cyclodextrin or its derivatives were used as double chiral selectors in BRCE, and separation factors α for some aromatic acid enantiomers have been significantly improved . But even so, ELLE involves exploring organic solvent/water systems, which have the disadvantages of emulsification and large consumption of toxic, flammable, and volatile organic solvents .…”

“…[19][20][21][22][23][24] Nevertheless, the application of many current chiral selectors is often limited to their solubility for many solvents. [24][25][26][27] The enantioselectivity of monophasic recognition extraction is relatively low with a chiral selector, whereas biphasic recognition chiral extraction (BRCE) can greatly improve the enantioselectivity by the cooperation of both the separation abilities of hydrophobic and hydrophilic chiral selectors. The combination of two chiral selectors enables forming hydrophobic and hydrophilic complexes with specific enantiomers and then being extracted into organic and aqueous phases, respectively.…”

“…The combination of two chiral selectors enables forming hydrophobic and hydrophilic complexes with specific enantiomers and then being extracted into organic and aqueous phases, respectively. [21][22][23][24][25][26][27] The key to successful separation is whether chiral selectors match target enantiomers in the reaction extraction. For example, tartaric esters and β-cyclodextrin or its derivatives were used as double chiral selectors in BRCE, and separation factors α for some aromatic acid enantiomers have been significantly improved.…”