Enantioselective liquid chromatography–mass spectrometry assay for the determination of ifosfamide and identification of the N-dechloroethylated metabolites of ifosfamide in human plasma

Oliveira, Regina V.; Onorato, Joelle M.; Siluk, Danuta; Walko, Christine M.; Lindley, Celeste; Wainer, Irving W.

doi:10.1016/j.jpba.2007.07.026

Cited by 19 publications

(15 citation statements)

References 28 publications

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“…115,116 IFO is a nonionic drug, and nonionic drugs are difficult to intercalate into LDHs. Nie and Hou intercalated IFO into Mg/Al LDHs by the surfactant-assisted method, in which they applied sodium dodecyl sulfate and sodium dodecylbenzenesulfonate.…”

Section: Ifosfamide Layered Double Hydroxidesmentioning

confidence: 99%

Inorganic nanolayers: structure, preparation, and biomedical applications

Saifullah¹,

Hussein²

2015

IJN

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Hydrotalcite-like compounds are two-dimensional inorganic nanolayers also known as clay minerals or anionic clays or layered double hydroxides/layered hydroxy salts, and have emerged as a single type of material with numerous biomedical applications, such as drug delivery, gene delivery, cosmetics, and biosensing. Inorganic nanolayers are promising materials due to their fascinating properties, such as ease of preparation, ability to intercalate different type of anions (inorganic, organic, biomolecules, and even genes), high thermal stability, delivery of intercalated anions in a sustained manner, high biocompatibility, and easy biodegradation. Inorganic nanolayers have been the focus for researchers over the last decade, resulting in widening application horizons, especially in the field of biomedical science. These nanolayers have been widely applied in drug and gene delivery. They have also been applied in biosensing technology, and most recently in bioimaging science. The suitability of inorganic nanolayers for application in drug delivery, gene delivery, biosensing technology, and bioimaging science makes them ideal materials to be applied for theranostic purposes. In this paper, we review the structure, methods of preparation, and latest advances made by inorganic nanolayers in such biomedical applications as drug delivery, gene delivery, biosensing, and bioimaging.

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Section: Ifosfamide Layered Double Hydroxidesmentioning

confidence: 99%

Inorganic nanolayers: structure, preparation, and biomedical applications

Saifullah¹,

Hussein²

2015

IJN

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“…21 Oxazophosphorine compounds are chiral molecules (asymmetric phosphorus) administered as a racemate mixture to the patient (the S-enantiomer has more potent anticancer activity). Protein-based columns [187][188][189][190][191][192] or polysaccharide-based columns 193,194 allow resolution of oxazophosphorine enantiomers. Ifosfamide enantiomers and their metabolites in urine and serum can be discriminated by a β-cyclodextrine capillary GC column.…”

Section: Dna Interactive Agentsmentioning

confidence: 99%

Antineoplastic drugs and their analysis: a state of the art review

Guichard

Guillarme

Bonnabry

et al. 2017

Analyst

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The number of patients suffering from cancer is constantly increasing and, consequently, the number of different chemotherapy treatments administered is increasing. Given the high reactivity and toxicity of antineoplastic drugs, analytical methods are required in all pharmaceutical fields, from drug development to their elimination in wastewater; including formulation quality control, environment and human exposure and therapeutic drug monitoring. The aim of this paper is to provide an overview of the analytical methods available for the determination of antineoplastic drugs in different matrices such as pharmaceutical formulations, biological and environmental samples. The applicability and performance of the reported methods will be critically discussed, with focus on the most commonly used antineoplastic drugs. Only conventional compounds and small molecules for targeted therapy will be considered in the present review.

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“…Ifosfamide contains a chiral centre and is prescribed as a racemic mixture, but the two enantiomers are metabolised by different cytochrome P450 enzymes. It may be advantageous to separate and quantify the two enantiomers to obtain a clear picture of the pharmacokinetics and metabolism of this drug; this can be achieved using SPE with HLB cartridges and chromatography on a Chirabiotic T column [188]. Busulfan is used in preparative regimes for haemopoieitc stem cell transplantation in adults and children.…”

Section: Anticancer Drugsmentioning

confidence: 99%