2020
DOI: 10.1016/j.jpba.2020.113549
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Enantioselective separation of zopiclone on immobilized polysaccharide chiral stationary phase by HPLC: Method development and validation

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Cited by 9 publications
(5 citation statements)
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“…None of them showed sufficient enantioresolution. Finally, the Lux i-Amylose-1 column (immobilized amylose tris(3,5-dimethylphenylcarbamate)) provided satisfactory results enabling validation of the method and its further use for the analysis of zopiclone in tablets [ 37 ]. The ( R )- and ( S )-zopiclone were also determined in human hair on a Chiral Art Cellulose-SC column based on immobilized cellulose tris(3,5-dichlorophenylcarbamate) using previous optimized extraction to prevent decomposition of the analytes [ 38 ].…”
Section: Polysaccharide-based Stationary Phasesmentioning
confidence: 99%
“…None of them showed sufficient enantioresolution. Finally, the Lux i-Amylose-1 column (immobilized amylose tris(3,5-dimethylphenylcarbamate)) provided satisfactory results enabling validation of the method and its further use for the analysis of zopiclone in tablets [ 37 ]. The ( R )- and ( S )-zopiclone were also determined in human hair on a Chiral Art Cellulose-SC column based on immobilized cellulose tris(3,5-dichlorophenylcarbamate) using previous optimized extraction to prevent decomposition of the analytes [ 38 ].…”
Section: Polysaccharide-based Stationary Phasesmentioning
confidence: 99%
“…It has been acknowledged that the preparative separation of enantiomers by chromatography on CSPs is a suitable alternative to more traditional methods, such as enantioselective synthesis and enzymatically catalyzed transformations to acquire enantiopure drugs 22–25 . The screening of the chiral column and mobile phase takes place in the initial step of the chiral method development process, followed by the optimization of the remaining chromatographic conditions 26,27 . Upon screenings on various polysaccharide‐based stationary phases, namely, Chiralpak IA (amylose‐based) [tris(3,5‐dimethylphenylcarbamate)], Chiralpak IG (amylose‐based) [tris(3‐chloro‐5 methylphenylcarbamate)], and Chiralpak IC (Cellulose‐based) [tris(3,5‐dichlorophenylcarbamate)], an expected analytical chiral resolution was observed on Chiralpak IC.…”
Section: Resultsmentioning
confidence: 99%
“…[22][23][24][25] The screening of the chiral column and mobile phase takes place in the initial step of the chiral method development process, followed by the optimization of the remaining chromatographic conditions. 26,27 [tris(3,-5-dichlorophenylcarbamate)], an expected analytical chiral resolution was observed on Chiralpak IC. For analytical separations, Chiralpak IC was employed, and the retention factor (k) for the first eluted enantiomer, separation factor (α), and the resolution (R s ) were found as 0.17, 1.29, and 2.45, respectively.…”
Section: Enantioselective Hplc Methods Optimizationmentioning
confidence: 94%
“…It is known that chiral separation is influenced by both enantioselective (chiral) and nonselective (achiral) interactions, which can significantly vary with temperature [21]. Partition behavior of enantiomers in HPLC mainly involves the transfer of analytes from mobile phase to stationary phase, and its retention mechanism could be studied by thermodynamic analysis.…”
Section: Resultsmentioning
confidence: 99%