Enantioselective Synthesis of (1R,2S) and (1S,2S) Dehydrocoronamic Acids

Cyclodextrins in Polymer Synthesis: Synthesis and Influence of Methylatedβ-Cyclodextrin on the Radical Polymerization Behavior of 1,1-Disubstituted 2-Vinylcyclopropane in Aqueous Medium

“…This aspect indicates a significant enantioselectivity and a relatively poor cis/trans selectivity of PLE toward vinylcyclopropane diesters. Some preliminary experiments of PLE-catalyzed hydrolysis of 1 have been reported by Fliche et al [15] However, to date, stereoselectivity has not been considered by these authors.…”

Biocatalytic routes to anti-viral agents and their synthetic intermediates

“…Ethyl-ACCA, a vaniprevir fragment, could be obtained through reduction of vinyl-ACCA. 267,268 Glecaprevir and voxilaprevir both contain a difluoromethyl-ACCA fragment. A team at Abbvie developed a synthetic route to glecaprevir in which difluoromethyl-ACCA was derived from vinyl-ACCA via multi-step chemical conversion.…”

Tailor‐Made α‐Amino Acids in the Pharmaceutical Industry: Synthetic Approaches to (1R,2S)‐1‐Amino‐2‐vinylcyclopropane‐1‐carboxylic Acid (Vinyl‐ACCA)

“…The first synthesis of enantiomerically enriched (1 R ,2 S )‐ N ‐Boc‐vinyl‐ACCA ( 43 ) was reported by Le Goffic and co‐workers in 1994 (Scheme ) . Racemic 1,1‐bis(methoxycarbonyl)‐2‐vinylcyclopropane ( 41 ) was easily prepared from dimethyl malonate ( 40 ) by S N 2–S N 2′ alkylation sequence with trans ‐1,4‐dibromo‐2‐butene ( 32 ) under basic conditions.…”