2007
DOI: 10.1016/j.molcatb.2006.09.006
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Enantioselective synthesis of 4,5,6,7-tetrahydro-4-oxo-benzofuran-5-yl acetate and 1-benzyl-4,5,6,7-tetrahydro-4-oxo-1(H)-indol-5-yl acetate using chemoenzymatic methods

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Cited by 5 publications
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“…-The synthetic routes to furopyrimidine and oxobenzofuran derivatives is not large, and only few procedures have been reported for the synthesis of furopyrimidines [1 -4], mostly relying on multi-step reactions giving low yields [1 -3]. These compounds are an important structural unit in natural products and are intermediates in drugs and organic synthesis [5] [6]. As part of our continuing interest in the development of new synthetic methods in heterocyclic chemistry and the recent interest in isocyanide-based multicomponent reactions [7 -10], we now describe an efficient synthesis of furopyrimidine and oxobenzofuran derivatives via the reaction of CH-acids with aldehydes and isocyanides in CH 2 Cl 2 at room temperature.…”
mentioning
confidence: 99%
“…-The synthetic routes to furopyrimidine and oxobenzofuran derivatives is not large, and only few procedures have been reported for the synthesis of furopyrimidines [1 -4], mostly relying on multi-step reactions giving low yields [1 -3]. These compounds are an important structural unit in natural products and are intermediates in drugs and organic synthesis [5] [6]. As part of our continuing interest in the development of new synthetic methods in heterocyclic chemistry and the recent interest in isocyanide-based multicomponent reactions [7 -10], we now describe an efficient synthesis of furopyrimidine and oxobenzofuran derivatives via the reaction of CH-acids with aldehydes and isocyanides in CH 2 Cl 2 at room temperature.…”
mentioning
confidence: 99%