Enantioselective synthesis of four isomeric building blocks useful in the synthesis of 2-nor-leukotriene analogues

First stereoselective total synthesis of 4(S),5(S)-oxido-17(S)-hydroxy-6(E),8(E),10(Z),13(Z),15(E),19(Z)-docosahexaenoic acid, the biosynthetic precursor of resolvins D3 and D4

“…At this point, we envisaged the alternative route to allow epoxide installation prior to methoxycarbonyl formation, thus bypassing said Lewis acid-mediated intramolecular attack. A similar strategy was employed to produce four isomeric epoxides critical in the synthesis of 2-nor-leukotriene analogs, 20 therefore making this a promising strategy.…”

Catalytic Enantioselective Synthesis of 4-Vinyl-2-trichloromethyloxazoline: An Access to Enantioenriched Vinylglycinol Surrogate

“…Molecular sieves 4 Å and DBU (76 mg; 75 μL; 0.5 mmol) were added to a solution of E- but-2-en-1,4-diol ( 6 ) (0.95 g; 10.8 mmol) in THF (15 mL) at room temperature. The solution was cooled to −5 °C and to this trichloroacetonitrile (3.75 g; 2.61 mL, 26.0 mmol) was added.…”

“…Experimental Section E-7. Molecular sieves 4 A ˚and DBU (76 mg; 75 μL; 0.5 mmol) were added to a solution of E-but-2-en-1,4-diol 22 (6) (0.95 g; 10.8 mmol) in THF (15 mL) at room temperature. The solution…”

Εφαρμογή Της Βιοκατάλυσης Σε Μη Συμβατικά Συστήματα Στην Αξιοποίηση Των Συστατικών Της Μαστίχας

“…λευκοτριενίων [Bellamy et al 1992, Franck Neumann & Colson 1991, φερεμόνων εντόμων [Millar et al 1990, Rollin & Klaffke 1991, στεροειδών [Joannou fit Reeder 1996, Scherlitz Hoffmann et al 1996] και αντιβιοτικών ενώσεων [Evans et al 1991, Gala & Dibenedetto 1994, Ng et al 1995, Zhang et al 1995. Αλλα παραδείγματα χρήσης των εποξειδίων για τη σύνθεση πολύπλοκων μορίων έχουν δημοσιευτεί από τους Buntel Et Griffin [1992], Chen et al [1993], Corey et al [1994], Frey et al…”