Enantioselective Total Synthesis of (−)- and (+)-Petrosin

Toya, Hiroki; Okano, Kentaro; Takasu, Kiyosei; Ihara, Masataka; Takahashi, Atsushi; Tanaka, Haruo; Tokuyama, Hidetoshi

doi:10.1021/ol1022257

Cited by 20 publications

(10 citation statements)

References 20 publications

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“…The results of this study reinforce some previous research which states that the integration of modulebased PBL in learning can improve student learning outcomes (Gorghiu et al, 2015;Miharja, Syamsuri, & Saptasari, 2015). The implementation carried out steadily and consistently is proven to be able to improve students' critical thinking skills (El-Shaer & Gaber, 2014;Zabit, 2010). Problems that are used as learning resources become triggers that respond to students' thinking skills (Jonassen, 2011;Sada, Mohd, Adnan, & Yusri, 2016).…”

Section: Resultsmentioning

confidence: 99%

“…PBL is informed of being able to improve concepts mastery, both junior high school (Zakariya, Ibrahim, & Adisa, 2016), senior high school (Yulianti, 2017), and college students (Zhang et al, 2015). Some studies also report that the application of PBL is also able to empower various students' thinking skills, such as critical (El-Shaer & Gaber, 2014;Ulger, 2018), creative (Sihaloho, Sahyar, & Ginting, 2017;Ulger, 2018), metacognitive (Adnan & Bahri, 2018), and problem-solving thinking skills (Jonassen, 2011).…”

Section: Introductionmentioning

confidence: 99%

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Improving student learning outcomes in science subjects through the implementation of PBL-based module

Nursa’ban

Masykuri

Yamtinah

2019

JPBI

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Problem-based learning (PBL) has been reported as one of the learning models which can improve student learning outcomes optimally. Unfortunately, the frequency of implementing PBL and the teacher knowledge level about PBL is not optimal yet. This quantitative descriptive study aimed at determining the effect of PBL-based modules implementation on student learning outcomes. The population of this study was the XI grade students of SMAN 2 Wera in which the sample was the students of XI-Natural Science Class. Test was chosen as an instrument in the data collection process which was given at the beginning and the end of the implementation. The dependent-test was performed, after collecting the data. The study results indicated that the student learning outcomes increased significantly. Therefore, the application of PBL-based module is recommended to be carried out during science learning of XI graders.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Improving student learning outcomes in science subjects through the implementation of PBL-based module

Nursa’ban

Masykuri

Yamtinah

2019

JPBI

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“…PBL is often assessed in its potential in various previous studies. However, various studies more often examine the effect of PBL on students' thinking skills (Anugraheni, 2018;Asyari, Muhdhar, Susilo, & Ibrahim, 2016;El-Shaer & Gaber, 2014;Ramdiah, Abidinsyah, & Mayasari, 2018), metacognition (Gholami et al, 2016;Kuvac & Koc, 2019), literacy (Febriasari & Supriatna, 2017;Shultz & Li, 2016;Suwono, Pratiwi, Susanto, & Susilo, 2017), learning outcomes (Nursa'ban, Masykuri, & Yamtinah, 2019;Yew & Goh, 2016), learning motivation (Argaw, Haile, Ayalew, & Kuma, 2017;Koçakoǧlu, Türkmen, & Solak, 2010;Thakur & Dutt, 2017), or attitudes (Demirel, 2016;Kuvac & Koc, 2018;Veli, 2014) . In fact, UEC is also a competency that needs to be optimally empowered, especially the increasingly critical environmental conditions at this time.…”

Section: Introductionmentioning

confidence: 99%

The effect of problem-based learning and naturalist intelligence on students' understanding of environmental conservation

Suhirman

Yusuf

2019

JPBI

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Environmental conservation understanding is one of the crucial factors which determines student attitudes and behavior towards the environment. This study aimed to investigate the effects of problem-based learning and naturalist intelligence on the students' understanding of environmental conservation. This experimental research was conducted at Madrasah Aliyah Negeri (MAN) 1 Praya which employed factorial design. The first factor was the levels of naturalist intelligence (high and low) and the second factor was learning forms (problem-based and expository learning). Two groups were randomly selected from X-MIPA graders of MAN 1 Praya. The data were collected through tests which then were analyzed using ANOVA at 0.05 significance level. The results of the study indicated that problem-based learning affected the students' understanding of environmental conservation, while naturalist intelligence did not affect it. Furthermore, there were no interaction between these two factors.

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“…Constraint of conformationb ytrans-fused rings by Tokuyama and co-workers. [42] Angewandte Chemie Minireviews expected, the RCM reaction of 13-3 proceeded well to afford the 16-membered intermediate,w hich could be transformed into petrosin after the saturation of the double bond.…”

Section: Fused-ring Systemsmentioning

confidence: 93%

Conformational Design Principles in Total Synthesis

et al. 2020

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Conformation is one of the most fundamental concepts in organic chemistry for chemists to visualize a molecule as a three‐dimensional object in addition to its constitution and configuration. Conformational factors significantly affect the physical properties, chemical reactivities, and biological activities of a molecule. The significance of conformational design has been generally recognized since its successful application in the total synthesis of complex natural products, such as vitamin B12 and erythronolide. Conformational analysis, especially intentional control of conformational preferences by conformational design, could play a critical role in the synthesis of complex organic molecules by guiding the formation of bonds, stereocenters, or rings. This Minireview highlights selected examples of conformational design in natural‐product synthesis, with particular emphasis on the applications and new insights advanced in the last 20 years. The examples discussed herein are divided into three categories by structural features of the substrates: open‐chain type, cyclohexane type, and medium‐ and large‐ring type.

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Enantioselective Total Synthesis of (−)- and (+)-Petrosin

Cited by 20 publications

References 20 publications

Improving student learning outcomes in science subjects through the implementation of PBL-based module

Improving student learning outcomes in science subjects through the implementation of PBL-based module

The effect of problem-based learning and naturalist intelligence on students' understanding of environmental conservation

Conformational Design Principles in Total Synthesis

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