Enantioseparation of a novel “click” chemistry derived native β-cyclodextrin chiral stationary phase for high-performance liquid chromatography

Cationic cyclodextrin clicked chiral stationary phase for versatile enantioseparations in high-performance liquid chromatography

“…The click chemistry of Cu(I) catalyzed 1,3-dipolar cycloadditions has been extensively used for the effective immobilization of functional molecules onto substrate surfaces [11,12]. A large spectrum of clicked CD-CSPs has thus been generated for practical chromatographic separations [13][14][15][16][17][18].…”

In-column “click” preparation of hydrophobic organic monolithic stationary phases for protein separation

“…Owing to its broad chemical orthogonality and versatility, the CuAAC implementation of "click chemistry" has been utilized in diverse disciplines ranging from materials science and nanotechnology to drug discovery and pharmacology [18,19]. The CuAAC reaction has been used to prepare stationary phases by immobilization of different functional groups onto organic/inorganic HPLC packing materials [20][21][22][23][24]. Recently, some research employing this "click" strategy for functionalization of monolithic stationary phases were reported.…”

Sub-1-micron mesoporous silica particles functionalized with cyclodextrin derivative for rapid enantioseparations on ultra-high pressure liquid chromatography

“…Several methods of bonding of ␤-CD moieties onto the silica support have been developed and successfully applied in chiral separation. Our group have previously reported a series of structurally well-defined CSPs by several bonding strategies such as Staudinger reaction [26,32], Click chemistry [33,34] and polymerization [25]. Herein, we prepared a chemically bonded perphenylcarbamoylated-␤-CD based CSP by a polymerization step between thiol-functionalized silica and mono-6 A -allayamino-␤-CD.…”