Enantioseparation of racemic amlodipine using immobilized ionic liquid by solid‐phase extraction

Abstract

In this paper, a novel l‐glutamate based immobilized chiral ionic liquid (SBA‐IL (Glu)) was prepared by chemical bonding method and applied as a solid sorbent for chiral separation of amlodipine. The performance of SBA‐IL (Glu) was investigated for the absorption of (S)‐amlodipine and separation of amlodipine enantiomer. The static experiment showed that equilibrium adsorption was achieved within 80 minutes, and the saturation adsorptions capacity was 12 mg/g. The complex was then packed in a glass chromatographic column for the separation of amlodipine and the enantiomeric excess (%ee) of (S)‐amlodipine reached 24.67%. The immobilized ionic liquids exhibit good reusability, and the separation efficiency remains 18.24% after reused five times, which allows potential scale‐up for the chiral separation of amlodipine.

Computational investigation of metal organic frameworks as potential drug carriers for antihypertensive amlodipine

“…Correlations between amlodipine uptakes of metal organic frameworks (MOFs) and their (A) pore volumes, (B) largest cavity diameter, (C) pore limiting diameter selected porous materials will be employed as drug carries for antihypertensive amlodipine, it is essential to ensure that the screened MOFs have a high amlodipine uptake capacity. Our results showed that MIL-100, MIL-101, bio-MOF-100, Cu-BTC, IRMOF series, and MOF-74 series can generally outperform traditional amlodipine storage materials such as SBA-IL (12 mg/g), 35 PMAA@mSiO 2 (201 mg/g) 2 ,…”

Enantioselective adsorption of ibuprofen enantiomers using chiral‐active carbon nanoparticles induced S‐α‐methylbenzylamine

“…7 In contrast, the chiral separation or resolution of racemate (a mixture with equal amounts of enantiomers) remains the most commonly used strategy for obtaining optically pure chiral compounds, which mainly include diastereomeric crystallization, [8][9][10] chiral chromatography, 11 chiral liquid-liquid extraction, 12,13 and chiral adsorption. [14][15][16][17] Among them, the adsorption method is universally known for its low cost, high efficiency, simple operation, and recyclability. Therefore, adsorption based on a chiral absorbent is a promising technique for enantiomer separation and has great potential in application to the industry.…”

“…Although the asymmetric synthetic approach has made remarkable progress in the last two decades, the accepted highly selective reactions that can provide pure enantiomers on an industrial scale are still limited 7 . In contrast, the chiral separation or resolution of racemate (a mixture with equal amounts of enantiomers) remains the most commonly used strategy for obtaining optically pure chiral compounds, which mainly include diastereomeric crystallization, 8–10 chiral chromatography, 11 chiral liquid–liquid extraction, 12,13 and chiral adsorption 14–17 . Among them, the adsorption method is universally known for its low cost, high efficiency, simple operation, and recyclability.…”