Enantioseparation of semisynthetic ergot alkaloids on vancomycin and teicoplanin stationary phases

Effect of the eluent on enantiomer separation of controlled drugs by liquid chromatography–ultraviolet absorbance detection–electrospray ionisation tandem mass spectrometry using vancomycin and native β-cyclodextrin chiral stationary phases

“…Matching the results with Table 2 The precursors and recorded product ions and enantioresolution (R s ), retention factor (k) and separation factor (α) obtained with the best eluent compositions of each mode (vancomycin in RP and POP, ␤-CD in RP and POP) MA, none of the enantiomers of the amphetamine derivatives were separated. These results are in agreement with the earlier observation: MeOH provides superior enantioseparation for basic drugs with a vancomycin column [33], although ACN provides more efficient enantioseparation for other type of compounds than MeOH [32]. The effect of the amount of the organic modifier on retention gave U-shaped retention curves that are typical for glycopeptide columns (Fig.…”

Chiral separation by chromatographic and electromigration techniques. A Review

“…Hydrophobic parts of the analyte may be included into the hydrophobic basket and hydrogen bonds with the pendant arms as well as dipole stacking, ionic-, p-p interactions and steric repulsions are assumed to be the main interactions responsible for chiral recognition. Vancomycin [131] found application among others to the chiral separation of barbiturates, hydantoins, piperidine-2,6-dione and cyclic amides [136], dihydropyrimidinones [137], pyridone derivatives [138] and semi-synthetic ergot alkaloids [139]. A CSP based on vancomycin derivatized with 3,5-dimethylphenylisocyanate [131] showed different chiral recognition ability and resolved for example hydroxyzine and althiazide.…”

Fases estacionárias quirais para cromatografia líquida de alta eficiência

“…[94][95][96][97][98] Porém, as CSPs de vancomicina e ristocetina também são úteis para a separação destes compostos. 89,99 Ademais, essas fases quirais apresentam enantiosseletividade para uma grande variedade de classes de compostos, tais como lactonas, 89 sulfóxidos 100 e alcaloides, 101 e fazem parte do protocolo de separação de produtos racêmicos de corporações farmacêuticas.…”