Enantioseparation of tiropramide by HPLC

Ryoo, Jae Jeong; Heo, Kyu Sung; Choi, Eun-Soon; Park, Jung Hag; Lee, Won–Jae

doi:10.1002/chir.20050

Cited by 2 publications

(2 citation statements)

References 12 publications

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“…[1][2][3][4] Chiral stationary phases (CSPs) are essential absorbent materials for chiral HPLC columns. 5 In this technique, enantioseparation results from the difference of the interactions between a pair of enantiomers and CSPs.…”

Section: Introductionmentioning

confidence: 99%

The comparison in enantioseparation ability of the chiral stationary phases with single and mixed selector—The selectors derived from two D‐tartrates

Chen

Xiao

et al. 2010

Chirality

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(2S,3S)-2,3-Bis(3,5-dimethylphenylcarbonyloxy)-3-(benzyloxycarbonyl)-propanoic acid and (2S,3S)-2,3-bis(1-naphthalenecarbonyloxy)-3-(benzyloxycarbonyl)-propanoic acid were synthesized from D-tartaric acid. These two compounds were chlorinated to afford two chiral selectors for chiral stationary phases (CSPs). The selectors were separately immobilized on aminated silica gel to give two single selector CSPs; and were simultaneously immobilized to obtain a mixed selector CSP. Comparing to the single selector CSPs, the mixed selector CSP bears the enhanced enantioseparation ability, suggesting that the two selectors in the mixed selector CSP are consistent for chiral recognition in most mobile phase conditions.

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Section: Introductionmentioning

confidence: 99%

The comparison in enantioseparation ability of the chiral stationary phases with single and mixed selector—The selectors derived from two D‐tartrates

Chen

Xiao

et al. 2010

Chirality

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“…The silica gel can be derivatized with an alcohol functional group, thus initially used for the Pirkle-type CSPs. For the Pirkle-type stationary phases, π-acidic functional group, [90][91][92][93] stationary phases with a π-basic functional group, [94][95][96][97][98] and stationary phases with both π-acidic and π-basic functional groups are introduced to the CSPs. [99][100][101][102][103][104] (1S,2R)-Norephedrine was first introduced to produce a diastereomeric π-acidic Pirkle-type CSP using an amino alcohol as a starting material.…”

Section: Introductionmentioning

confidence: 99%

Amino alcohol‐derived chiral stationary phases

2023

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An updated minireview of chiral stationary phases (CSPs) based on amino alcohols is presented. In this minireview, we focused on amino alcohols as starting materials in preparation of chiral catalysts for asymmetric organic synthesis and CSPs for chiral separations. Among the various CSPs, we summarized the important developments and applications of the amino alcohol‐based Pirkle‐type CSPs, ligand exchange CSPs, α‐amino acid‐derived amino alcohol CSPs, and symmetric CSPs from their first appearance to the present day to propose ideas for the development of new CSPs with improved performance.

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Enantioseparation of tiropramide by HPLC

Cited by 2 publications

References 12 publications

The comparison in enantioseparation ability of the chiral stationary phases with single and mixed selector—The selectors derived from two D‐tartrates

The comparison in enantioseparation ability of the chiral stationary phases with single and mixed selector—The selectors derived from two D‐tartrates

Amino alcohol‐derived chiral stationary phases

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