Encapsulated papillary breast carcinoma in a male patient in association with microdeposits of carcinoma cells in the needle track and sentinel lymph node treated conservatively

Stolnicu, Simona; Giurgi, Alexandra; Bauer, Orsolya; Chiriac, Anca; Podoleanu, Cristian; Georgescu, Rareş

doi:10.5114/pjp.2018.76702

Cited by 3 publications

(2 citation statements)

References 11 publications

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“…EPC is a rare malignancy of the breast and considered a viariant of DCIS. It accounts for less than 0.5-1% of breast cancer cases and mostly occurs in postmenopausal women but also in men in some cases [1,2]. EPC is usually considered a variant of carcinoma in situ and treated in accordance with carcinoma in situ management [3].…”

Section: Discussionmentioning

confidence: 99%

“…EPC of the breast, also commonly referred to as intracystic papillary carcinoma, is a rare form of breast cancer that accounts for less than 1-2% of breast cancer cases [1]. EPC mostly occurs in postmenopausal women but also in men in some cases [2]. The WHO maintains that if EPC is not accompanied by in ltrative oncogenic components, it should be staged as papillary carcinoma in situ, which has an excellent prognosis [3].…”

Section: Introductionmentioning

confidence: 99%

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Encapsulated Papillary Carcinoma of The Breast: A Case Series

Wang

Pan

et al. 2021

Preprint

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Introduction: Encapsulated papillary carcinoma (EPC）of the breast is a rare type of breast cancer with excellent prognosis. It is usually considered a variant of ductal carcinoma in situ (DCIS). However, no consensus on EPC treatment and management has been achieved. We provide some data from our clinical centers to help better manage this disease.Methods: We performed a retrospective analysis of patients diagnosed with EPC from March 2015 to December 2019 at The First Affiliated Hospital of Anhui Medical University. Demographic information, tumor details, immunohistochemical markers, clinical data, stage of the disease, treatment modalities, and oncological outcomes were collected.Results: Eleven cases were included in this retrospective study: three cases had pure EPC, six cases had EPC associated with DCIS, and two cases had EPC associated with invasive cancer. Among the patients, two had lymph node metastases. The mean age of female patients at diagnosis was 53.6 years. The one male patient was 48 years old. The mean tumor size was 2.4 cm. Myoepithelial cell layers were completely absent in all cases. Ten patients were estrogen receptor and progesterone receptor positive and human epidermal growth factor receptor-2 negative. Nine patients underwent mastectomy, and two underwent breast-conserving surgery.Conclusion: Adequate local therapy results in excellent prognosis. Radiation therapy should be offered to patients with EPC who undergo breast-conserving surgery. Immunohistochemistry is necessary in diagnosing EPC and excluding other papillary lesions. Excisional biopsy should be performed to achieve comprehensive diagnosis. Sentinel lymph node biopsy is recommended for patients with EPC.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Encapsulated Papillary Carcinoma of The Breast: A Case Series

Wang

Pan

et al. 2021

Preprint

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Papillary Lesions of the Male Breast

Zhong

Cheng

Goldfischer

et al. 2019

American Journal of Surgical Pathology

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Papillary lesions of the male breast (PLMB) are uncommon. To date, PLMB have been reported as individual case reports and in relatively small series. We reviewed cases of PLMB diagnosed at our medical center over a 19-year (2000-2019) period. A total of 117 cases were identified, with an age range of 7 months to 88 years. These cases included 3 of papillary ductal hyperplasia, 5 intraductal papillomas, 1 adenomyoepithelioma, 5 atypical papillomas (ie, papillomas with atypia), 51 papillary ductal carcinoma in situ, 14 encapsulated papillary carcinomas, 38 solid papillary carcinomas, and 8 invasive papillary carcinomas. Malignant papillary neoplasms, including invasive and noninvasive ones, had a mean size of 1.3 cm (range: 0.3 to 4.4 cm), and all were ER+ and HER2−. Fifty-four percent (19/35) of carcinomas were treated with excision alone, 46% (16/35) underwent mastectomy, and 63% (22/35) had axillary lymph node sampling. Only one case had metastatic involvement of axillary lymph nodes. Of the cases with follow-up, no (0/8) invasive carcinoma showed distant metastasis or proved fatal, and no (0/23) noninvasive papillary carcinoma recurred. Two notable cases of PLMB were encountered: one of a 7-month-old boy with NF1 mutation and florid papillary hyperplasia, and another of a 57-year-old man with Klippel-Feil syndrome and bilateral solid papillary carcinoma, invasive and oligometastatic on one side and noninvasive on the other. On the basis of this study of PLMB cases, the largest to date, and review of literature, we conclude that PLMB span a broad clinicopathologic spectrum, and that both invasive and noninvasive papillary carcinomas have relatively good prognosis.

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Literature review and case report of bilateral intracystic papillary carcinoma associated with an invasive ductal carcinoma in a male breast

Avau

Marie

Baudry

et al. 2021

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Intracystic papillary carcinoma (IPC) is a rare tumor with good prognosis that occurs in only 5% to 7.5% of male breast cancer. We report a case of a 46-year-old man who presented a brown nipple discharge a few months ago. He had a bilateral IPC and an invasive ductal carcinoma on the right breast. A double mastectomy was then performed with a bilateral sentinel lymph node biopsy, and he received chemotherapy, radiotherapy, and hormonotherapy. Two years after the diagnosis, the patient recovered and was free of recurrence. Considering the scarcity of this tumor type, we conducted a systematic literature review on the PubMed of all the cases of IPC in men. The clinical presentation, imaging, and treatment of the 43 case reports from the 41 articles selected were described. Furthermore, no clear guidelines for IPC management are available. Conservative surgery should also be preferred, and a sentinel lymph node biopsy should be performed systematically. Moreover, radiotherapy should be proposed in the case of conservative surgery, and hormone therapy could be proposed in the case of invasive IPC or IPC associated with a ductal carcinoma in situ.

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Encapsulated papillary breast carcinoma in a male patient in association with microdeposits of carcinoma cells in the needle track and sentinel lymph node treated conservatively

Cited by 3 publications

References 11 publications

Encapsulated Papillary Carcinoma of The Breast: A Case Series

Encapsulated Papillary Carcinoma of The Breast: A Case Series

Papillary Lesions of the Male Breast

Literature review and case report of bilateral intracystic papillary carcinoma associated with an invasive ductal carcinoma in a male breast

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