Encapsulated stem cells for cancer therapy

Shah, Khalid

doi:10.4161/biom.24278

Cited by 44 publications

(20 citation statements)

References 80 publications

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“…The most commonly used polysaccharide‐based biomaterial in 3D colony formation assays is agarose (Willerth & Sakiyama‐Elbert, ). Alginate, another utilized polysaccharide, forms scaffolds through the use of ionic cross‐linking, allowing for encapsulation of cells, and has been successfully used in a series of cancer treatment studies (Shah, ). However, two additional polymers may be more effective than either agarose or alginate.…”

Section: Modifying Three‐dimensional Cancer Stem Cell Modelsmentioning

confidence: 99%

Three‐dimensional cell culture model utilization in cancer stem cell research

Bielecka

Maliszewska‐Olejniczak

et al. 2016

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Three-dimensional (3D) cell culture models are becoming increasingly popular in contemporary cancer research and drug resistance studies. Recently, scientists have begun incorporating cancer stem cells (CSCs) into 3D models and modifying culture components in order to mimic in vivo conditions better. Currently, the global cell culture market is primarily focused on either 3D cancer cell cultures or stem cell cultures, with less focus on CSCs. This is evident in the low product availability officially indicated for 3D CSC model research. This review discusses the currently available commercial products for CSC 3D culture model research. Additionally, we discuss different culture media and components that result in higher levels of stem cell subpopulations while better recreating the tumor microenvironment. In summary, although progress has been made applying 3D technology to CSC research, this technology could be further utilized and a greater number of 3D kits dedicated specifically to CSCs should be implemented.

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Section: Modifying Three‐dimensional Cancer Stem Cell Modelsmentioning

confidence: 99%

Three‐dimensional cell culture model utilization in cancer stem cell research

Bielecka

Maliszewska‐Olejniczak

et al. 2016

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“…Living cells are encapsulated in polymeric microspheres or microcapsules for many biomedical and biotechnological applications, including local and long-term drug delivery and regenerative medicine. [77][78][79][80][81] The microencapsulation of cells allows the free exchange of nutrients and waste while excluding agents of the immune system, thereby promoting the survival of the transplanted cells. It also permits the release of therapeutic cell products.…”

Section: Microencapsulated Cellsmentioning

confidence: 99%

<p>Nanocarriers and nonviral methods for delivering antiangiogenic factors for glioblastoma therapy: the story so far</p>

Clavreul¹,

Pourbaghi-Masouleh²,

Roger³

et al. 2019

IJN

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Angiogenesis, the formation of new blood vessels, is an essential component of glioblastoma (GB) progression. The development of angiogenesis inhibitor therapy, including treatments targeting vascular endothelial growth factor (VEGF) in particular, raised new hopes for the treatment of GB, but no Phase III clinical trial to date has reported survival benefits relative to standard treatment. There are several possible reasons for this limited efficacy, including VEGF-independent angiogenesis, induction of tumor invasion, and inefficient antiangiogenic factor delivery to the tumor. Efforts have been made to overcome these limitations by identifying new angiogenesis inhibitors that target angiogenesis through different mechanisms of action without inducing tumor invasion, and through the development of viral and nonviral delivery methods to improve antiangiogenic activity. Herein, we describe the nonviral methods, including convection-enhanced delivery devices, implantable polymer devices, nanocarriers, and cellular vehicles, to deliver antiangiogenic factors. We focus on those evaluated in intracranial (orthotopic) animal models of GB, the most relevant models of this disease, as they reproduce the clinical scenario of tumor progression and therapy response encountered in GB patients.

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“…[39] Additionally, with the advancement of stem cell research, there is an increased potential for cancer therapy by using encapsulated stem cells. [40]…”

Section: Cancermentioning

confidence: 99%

Encapsulation of Transgenic Cells for Gene Therapy

Zhang¹

2015

Gene Therapy - Principles and Challenges

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A major challenge to emerging cell-based medicine including gene therapy is the host immune rejection of transplanted donor cells or engineered tissue. One way to address this problem is to use drugs to achieve immunosuppression. However, suppressing the patient's immune system may put the patient at risk for many other diseases. An alternative is to encapsulate living cells in macro/microcapsules to achieve immunoisolation of the cells, thereby increasing cell viability in the patient's body following transplantation. The capsule's membrane protects the encapsulated cells from being damaged by both the host's immune system and mechanical stress while allowing free diffusion of nutrients and metabolic waste for the cells to survive. Moreover, the membrane could be designed to achieve controlled and/or sustained release of therapeutic products produced by the encapsulated transgenic cells to treat a variety of diseases such as cardiovascular disorders, anemia, wounds, bone fractures, and cancer.

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Encapsulated stem cells for cancer therapy

Cited by 44 publications

References 80 publications

Three‐dimensional cell culture model utilization in cancer stem cell research

Three‐dimensional cell culture model utilization in cancer stem cell research

<p>Nanocarriers and nonviral methods for delivering antiangiogenic factors for glioblastoma therapy: the story so far</p>

Encapsulation of Transgenic Cells for Gene Therapy

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