Encapsulation and Delivery of Nutraceuticals and Bioactive Compounds by Nanoliposomes and Tocosomes as Promising Nanocarriers

Shahgholian, Narges

doi:10.1002/9781119746843.ch17

Cited by 5 publications

(2 citation statements)

References 113 publications

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“…Particularly, the self-assembly approach holds great promise for designing effective delivery systems. , Liposomes are one of the drug delivery systems that are frequently used as a carrier for the lipophilic and hydrophilic antioxidant agents to evaluate their antioxidant activities . Moreover, liposomes are also used as an efficient delivery system for water-soluble (e.g., glutathione, N-acetylcysteine, and quercetin) and lipid-soluble (e.g., tocopherol and CoQ10) antioxidant medicines to various organs and tissues for the treatment of oxidative stress-associated damage. − Recently, there has been a growing interest in exploring innovative approaches to enhance drug delivery systems for improved bioavailability and therapeutic efficacy. , Among these approaches, the incorporation of bioactive compounds into the structure of liposomes has gained significant attention . Liposomes, as versatile and biocompatible nanocarriers, have shown great potential for encapsulating a wide range of therapeutic agents.…”

Section: Introductionmentioning

confidence: 99%

“… 11 , 12 Among these approaches, the incorporation of bioactive compounds into the structure of liposomes has gained significant attention. 13 Liposomes, as versatile and biocompatible nanocarriers, have shown great potential for encapsulating a wide range of therapeutic agents. The current research expressed the potential novel use of γ oryzanol, the rice bran oil bioactive ingredient, as a replacement for the conventional lipid-based liposome structure.…”

Section: Introductionmentioning

confidence: 99%

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Liposome Nanocarriers Based on γ Oryzanol: Preparation, Characterization, and In Vivo Assessment of Toxicity and Antioxidant Activity

Jasim,

Albukhaty,

Sulaiman

et al. 2024

ACS Omega

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The present study aimed to develop and characterize liposome nanocarriers based on γ oryzanol and evaluate their potential in vitro and in vivo toxicity and antioxidant effects. The liposomes were physicochemically characterized using various techniques, including dynamic light scattering (DLS) for size and polydispersity index (PDI) measurements and ζ-potential analysis. The in vitro toxicity assessments were performed using hemolysis and MTT assays on the HS5 cell line. In vivo, acute oral toxicity was evaluated by using LD 50 assays in mice. Additionally, antioxidant activity was assessed through biochemical analysis of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels and liver tissue catalase, malondialdehyde (MDA), and glutathione (GSH) levels. The results revealed that the liposomes exhibited a uniform and spherical morphology with suitable physicochemical properties for drug delivery applications. The in vitro cytotoxicity and hemolysis assays and the in vivo LD 50 experiment indicated the potential safety of γ oryzanol liposomes, especially at lower concentrations. In addition, the assessment of liver enzymes, i.e., ALT and AST, and the antioxidant markers further revealed the safety of the formulation, particularly for the liver as a highly sensitive soft organ. Overall, the liposome nanocarriers based on γ oryzanol were successfully formulated and expressed potential safety, supporting their application for the purposes of drug delivery and therapeutic interventions, particularly for hepatocellular and antioxidant therapies; however, further investigations for preclinical and clinical studies could be the future prospects for liposome nanocarriers based on γ oryzanol to explore the safety and efficacy of these nanocarriers in various disease models and clinical settings.

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