Encapsulation efficiency of solid lipid hybrid particles prepared using the PGSS® technique and loaded with different polarity active agents

García‐González, Carlos A.; Argemí, Anna; Sousa, A.R. Sampaio de; Duarte, Catarina M.M.; Saurina, Javier; Domingo, Concepción

doi:10.1016/j.supflu.2010.05.011

Cited by 43 publications

(24 citation statements)

References 39 publications

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“…FTIR also highlighted a small extent of hydrogen bonding between GB and IBU which could have facilitated this. A similar formulation comprising ketoprofen in glyceryl monostearate-hydrogenated castor oil lipid particles has been reported 53 . Another noteworthy point is that from 40 to 60%, w/w IBU, the melting peak of IBU was still not observed (supplementary material).…”

Section: °Cmentioning

confidence: 95%

A study on the solid state characteristics of spray-congealed glyceryl dibehenate solid lipid microparticles containing ibuprofen

Wong

Heng

Chan

2015

Drug Development and Industrial Pharmacy

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Section: °Cmentioning

confidence: 95%

A study on the solid state characteristics of spray-congealed glyceryl dibehenate solid lipid microparticles containing ibuprofen

Wong

Heng

Chan

2015

Drug Development and Industrial Pharmacy

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“…Carbon dioxide (CO 2 ) is the most common supercritical fluid because it has mild critical temperature and pressure (31°C, 74 bar), and it is nontoxic, nonflammable, environmentally friendly, inexpensive, and safe. Previously, micron size solid lipid particles were generated using particle from gas‐saturated solutions (PGSS) or gas‐assisted melting atomization (GAMA) methods (Bertucco et al, ; García‐González et al, ; Lubary et al, ; Mandžuka and Knez, ; Sampaio de Sousa et al, ). Lubary et al () used a similar process called supercritical melt micronization to form and collect the particles from nonchemically modified low‐melting lipids, namely, anhydrous milk fat and a diacylglycerol‐based modified milk fat.…”

Section: Introductionmentioning

confidence: 99%

Formation of Low‐Density and Free‐Flowing Hollow Microparticles from Butter and Fractionated Palm Oil Mixture

Gudeman

Yang

Ciftci

2018

J Americ Oil Chem Soc

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The use of solid fats is challenging due to difficulty in incorporating into foods, handling during industrial food production, and relatively high-calorie contributions. The objective of this study was to form free-flowing and low-density hollow microparticles from nonhydrogenated fats, namely, butter and fractionated palm oil, using a novel method based on atomization of a carbon dioxide (CO 2 )expanded lipid mixture. The melting point of the fractionated palm oil decreased from 66.2 to 47.3 C above 120 bar in the presence of pressurized CO 2 . The density of the particles decreased fivefolds compared to that of the original oils. The average particle size D [4,3] decreased from 67.0 to 27.1 μm when the concentration of fractionated palm oil was increased from 50% to 100%. The hollow structure was more pronounced for the particles obtained from higher melting oils/oil blends, as well as with more spherical uniformity. Ten percent (d 10% ) and 50% (d 50% ) of the palm oil particles were smaller than 4.5 and 23.0 μm, respectively, whereas they were 14.5 and 58.3 μm when mixed with butter at 50% butter concentration, respectively. Polymorphic form of α was more pronounced in the solid lipid particles, indicating that they had a less-ordered crystalline structure than the original oil. This new method forms low-density and free-flowing lipid powders that make the handling and storage of solid lipids feasible and convenient, and may provide reduced fat usage and calorie intake, and more rapid oil melting in mouth.Keywords Fractionated palm oil Á Butter Á Hollow solid lipid particle Á Supercritical carbon dioxide Á Melting J Am Oil Chem Soc (2019) 96: 147-158.

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“…Lipid particles loaded with ketoprofen were prepared by using the so‐called “Particle from Gas Saturated Solutions” (PGSS®) supercritical fluid technology according to the procedure described elsewhere 14. Briefly, a 0.5‐L high‐pressure stirred vessel (Parr Instruments) was used to perform the experiments.…”

Section: Methodsmentioning

confidence: 99%

“…In addition, nanoparticles of TiO 2 and silanized TiO 2 have been incorporated in some of the preparations because, as pointed out elsewhere, the drug loading can be increased due to the anti‐caking effect of the nanoparticles 13. A supercritical CO 2 method has been applied to produce the composite systems consisting of ketoprofen entrapped in the SLPs 14–17. The use of supercritical‐based technologies provides additional advantages dealing with lowering the degradation of labile drugs as well as obtaining products free of toxic organic solvents 18–20…”

Section: Introductionmentioning

confidence: 99%

Characterization of new topical ketoprofen formulations prepared by drug entrapment in solid lipid matrices

Argemí

Domingo

Sousa

et al. 2011

Journal of Pharmaceutical Sciences

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Encapsulation efficiency of solid lipid hybrid particles prepared using the PGSS® technique and loaded with different polarity active agents

Cited by 43 publications

References 39 publications

A study on the solid state characteristics of spray-congealed glyceryl dibehenate solid lipid microparticles containing ibuprofen

A study on the solid state characteristics of spray-congealed glyceryl dibehenate solid lipid microparticles containing ibuprofen

Formation of Low‐Density and Free‐Flowing Hollow Microparticles from Butter and Fractionated Palm Oil Mixture

Characterization of new topical ketoprofen formulations prepared by drug entrapment in solid lipid matrices

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