Encapsulation of Aspirin into parent and functionalized MCM-41, in vitro release as well as kinetics

Solanki, Priyanka; Patel, Anjali

doi:10.1007/s10934-019-00750-w

Cited by 7 publications

(5 citation statements)

References 43 publications

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“…Mt/M∞ = Ktn• n is the experimental power that demonstrates the type of release mechanism, wherever n = 1.0, 0.5, and 0 portended First-order, Higuchi, and zero order models respectively. 40 The DPH mechanism of release is best presented by this model with high correlation coefficient and high linearity. The drug release mechanism of all three samples is non-swellable matrix-diffusion due to n <0.5.…”

Section: Model Of Korsmeyer-peppasmentioning

confidence: 88%

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Synthesis and functionalization of mucoadhesive mesoporous silica particles containing diphenhydramine for treatment of aphthous ulcers

et al. 2023

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Introduction: Medications used to treat oral ulcers include corticosteroids, anesthetics, and antihistamines. These can be used as gels, mouthwashes, pastes, ointments, etc. Diphenhydramine hydrochloride (DPH) has local anesthetic properties that can help treat the aphthae. One of the drawbacks of the delivery to the transmucosal is the quick turnaround time of the gel, a mucous form that is located on the epithelial film surface. Methods: Therefore, it seems that the preparation of a carrier that has the characteristics of adhesive mucus can increase the duration of drug retention on the mucous surface. To solve this problem, mesoporous silica nanoparticles (MSNPs) were synthesized and functionalized with amino and thiol groups and suggested as a system of drug delivery. The properties and structure of MSNPs were investigated by dynamic light scattering (DLS), transmission electron microscopy (TEM), energy-dispersive X-ray spectroscopy (EDS), thermal gravimetric analysis (TGA), Fourier transform infrared spectroscopy (FTIR), and nitrogen adsorption-desorption isotherms (BET). Results: Our outcomes indicated that the average sizes of bare MSNPs (MSN), amino modified MSNPs (MSN-NH2), and thiol modified MSNPs (MSN-SH) were obtained to be 611, 655, and 655 nm respectively and the average pore size of MSN, MSN-NH2, and MSN-SH were about 2.42 nm, 2.42 nm, and 2.44 nm, respectively, according to the BJH (Barrett-Joyner-Halenda) pore size distribution. The release kinetics and release of DPH from mesoporous silica carriers were evaluated. Conclusion: Eventually, the mucoadhesive study and DPH-loaded particles were investigated. Also, the MSN-SH exhibited a high mucoadhesive capacity for buccal mucosa compared with MSN-NH2 and MSN.

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Section: Model Of Korsmeyer-peppasmentioning

confidence: 88%

“…The drug release mechanism of all three samples is non-swellable matrix-diffusion due to n <0.5. 40 In some studies, it has been seen that drug release from MSPs is in two stages. 18 Xue et al have observed that the two-step drug release is due to the physical and chemical binding of the drug to mesoporous silica.…”

Section: Model Of Korsmeyer-peppasmentioning

confidence: 99%

Synthesis and functionalization of mucoadhesive mesoporous silica particles containing diphenhydramine for treatment of aphthous ulcers

et al. 2023

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“…Having high surface area, high pore volume, favorable and controlled label pore uniformity, high hydrophobicity and relatively high thermal stability are the important features for developing novel heterogeneous catalysts. [1][2][3][4] Some of the catalysts are mainly made up of silica, SiO 2 . The surface of this catalysts Silica has specific advantages as support such as excellent thermal and chemical stability, ease of handling and profusion of exposed silanol (SiÀ OH) groups.…”

Section: Introductionmentioning

confidence: 99%

“…Over recent years, heterogeneous catalysis has been the subject of intensive research by chemical scientists in the field of catalysts. Having high surface area, high pore volume, favorable and controlled label pore uniformity, high hydrophobicity and relatively high thermal stability are the important features for developing novel heterogeneous catalysts [1–4] . Some of the catalysts are mainly made up of silica, SiO 2 .…”

Section: Introductionmentioning

confidence: 99%

MCM‐41@CPTMS as an Efficient and High‐Performance Catalyst for One‐Pot Construction of Indeno[1,2‐b]quinolin‐8‐one Derivatives**

Najafi,

Safaei‐Ghomi,

Sadat Oboudatian

2023

ChemistrySelect

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In this work, MCM‐41@CPTMS nanoparticles were readily prepared and evaluated as acidic nanosilica spheres for the synthesis of indeno[1,2‐b]quinolinone derivatives through one‐pot three‐component reaction of 1‐naphthylamine, aromatic aldehydes and 1,3‐indandione. A high surface area, a hexagonal array of uniform mesoporous, high thermal stability, recyclability, nontoxicity and the easy separation of the nanocatalyst, make this nanocatalyst very useful for the synthesis of organic compounds. Mesoporous silica nanoparticles (MSN) was prepared easily and affirmed to be effective and prepared the products with excellent yields under reflux conditions. The structure of obtained nanoparticles was characterized by FE‐SEM, TEM, EDX, FT‐IR, XRD, TGA and BET. This synthetic protocol provides several benefits such as excellent yields in short reaction times (83–97 %),saving costs, reusability of the catalyst (five runs), and low catalyst loading.

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“…The term M41S is used to classify various types of MCM (Mobil Composition of Matter). Types from this group include MCM-41, MCM-48, and MCM-50 [3]. MCM-41 (Mobil Composition of Matter No.41) is the type most studied because it has a regular hexagonal structure, large specific surface area, good thermal stability, and is easy to obtain compared to other types of M41S [4,5].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of MCM-41 Silica Mesoporous Modified with Zn Metal

et al. 2022

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MCM-41 and Zn-MCM-41 were successfully synthesized using hydrothermal and impregnation methods. The synthesized silica mesoporous was confirmed by characterizing the material using XRD, SEM-EDS, and BET-BJH analyses. XRD results showed three main peaks at angles of 2θ = 2.40° (100), 3.87° (200), and 4.49° (210), which are characteristics of mesoporous materials with hexagonal structures. SEM analysis showed that the surface morphology of Zn-modified MCM-41 formed aggregates of smaller particles. The EDS results showed that the amount of Zn in MCM-41 was 1.25%. Modification with Zn metal also affected the surface area and porosity of MCM-41, where the surface area, pore volume, and pore diameter decreased. Based on the adsorption-desorption analysis of N2 gas, both materials exhibit a type IV isotherm typical for mesoporous materials with an H1 hysteresis loop.

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Encapsulation of Aspirin into parent and functionalized MCM-41, in vitro release as well as kinetics

Cited by 7 publications

References 43 publications

Synthesis and functionalization of mucoadhesive mesoporous silica particles containing diphenhydramine for treatment of aphthous ulcers

Synthesis and functionalization of mucoadhesive mesoporous silica particles containing diphenhydramine for treatment of aphthous ulcers

MCM‐41@CPTMS as an Efficient and High‐Performance Catalyst for One‐Pot Construction of Indeno[1,2‐b]quinolin‐8‐one Derivatives**

Synthesis of MCM-41 Silica Mesoporous Modified with Zn Metal

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