Encapsulation of Curcumin and Curcumin Derivative in Polymeric Nanospheres

Sobh, Rokaya Aly; Mohamed, Wael S.; Moustafa, A. B.; Nasr, H. E.

doi:10.1080/03602559.2014.1003230

Cited by 18 publications

(12 citation statements)

References 49 publications

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“…Due to the problems of water insolubility and low bioavailability of curcumin or curcumin nanoparticles, it has been reported that biodistribution and bioavailability of curcumin or curcumin nanoparticles would be increased by encapsulation processes such as nanoemulsions, liposomes, micelles, polymeric micro or nanoparticles, phospholipid complexes and hydrogels which showed the potential for efficient drug delivery systems that minimize the delay and reduce the vulnerability of diseases in organisms [44,54,55]. Prasad et al [37] postulated that an increased amount and length of curcumin in blood circulation could enhance the tissue deposition and biological activity in animals.…”

Section: Introductionmentioning

confidence: 99%

Curcumin, Curcumin Nanoparticles and Curcumin Nanospheres: A Review on Their Pharmacodynamics Based on Monogastric Farm Animal, Poultry and Fish Nutrition

Moniruzzaman

Min

2020

Pharmaceutics

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Nanotechnology is an emerging field of science that is widely used in medical sciences. However, it has limited uses in monogastric farm animal as well as fish and poultry nutrition. There are some works that have been done on curcumin and curcumin nanoparticles as pharmaceutics in animal nutrition. However, studies have shown that ingestion of curcumin or curcumin nanoparticles does not benefit the animal health much due to their lower bioavailability, which may result because of low absorption, quick metabolism and speedy elimination of curcumin from the animal body. For these reasons, advanced formulations of curcumin are needed. Curcumin nanospheres is a newly evolved field of nanobiotechnology which may have beneficial effects in terms of growth increment, anti-microbial, anti-inflammatory and neuroprotective effects on animal and fish health by means of nanosphere forms that are biodegradable and biocompatible. Thus, this review aims to highlight the potential application of curcumin, curcumin nanoparticles and curcumin nanospheres in the field of monogastric farm animal, poultry and fish nutrition. We do believe that the review provides the perceptual vision for the future development of curcumin, curcumin nanoparticles and curcumin nanospheres and their applications in monogastric farm animal, poultry and fish nutrition.

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Section: Introductionmentioning

confidence: 99%

Curcumin, Curcumin Nanoparticles and Curcumin Nanospheres: A Review on Their Pharmacodynamics Based on Monogastric Farm Animal, Poultry and Fish Nutrition

Moniruzzaman

Min

2020

Pharmaceutics

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“…For centuries, it has been popularly used as a food additive and as an herbal medicine in several parts of South Asia [ 28 ]. The United States Food and Drug Administration (USFDA) generally regards curcumin as being safe (GRAS) due to its relatively low toxicity [ 29 ]. Despite its numerous health benefits, its pharmacological or nutraceutical applications are limited due to its poor oral bioavailability and low water solubility [ 28 ].…”

Section: Introductionmentioning

confidence: 99%

Curcumin-Loaded Human Serum Albumin Nanoparticles Prevent Parkinson’s Disease-like Symptoms in C. elegans

et al. 2022

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Parkinson’s disease is one of the most common degenerative disorders and is characterized by observable motor dysfunction and the loss of dopaminergic neurons. In this study, we fabricated curcumin nanoparticles using human serum albumin as a nanocarrier. Encapsulating curcumin is beneficial to improving its aqueous solubility and bioavailability. The curcumin-loaded HSA nanoparticles were acquired in the particle size and at the zeta potential of 200 nm and −10 mV, respectively. The curcumin-loaded human serum albumin nanoparticles ameliorated Parkinson’s disease features in the C. elegans model, including body movement, basal slowing response, and the degeneration of dopaminergic neurons. These results suggest that curcumin nanoparticles have potential as a medicinal nanomaterial for preventing the progression of Parkinson’s disease.

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“…The microemulsion system is the most efficient drug delivery system, which demonstrates high efficiency of drug trapping, release under a sunken environment, biodegradability, and easy removal from the body [2,3]. The microemulsion technique can produce polymer latexes with particle sizes lower than 50 nm, low viscosity, and wide temperature range stability [4,5].…”

Section: Introductionmentioning

confidence: 99%

“…The microemulsion technique can produce polymer latexes with particle sizes lower than 50 nm, low viscosity, and wide temperature range stability [4,5]. In situ microemulsion polymerization is considered to be an effective method in drug entrapment during the formation of polymer nanosphere [6][7][8]. In the drug delivery application, CNTs were used due to their hollow nanostructures and fantastic physicochemical features [9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Tailoring nano-copolymer/CNTs composite and its application in drug delivery

et al. 2021

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This work aimed to overcome the main drawbacks of some essential anticancer drugs as 5-Fluorouracil (5-FU) by controlled loading with novel drug carriers. By a differential microemulsion technique, nanosized particles derived from a copolymer of poly(methyl methacrylate (MMA) and 2-hydroxyethyl methacrylate (HEMA)) with different monomer ratios have been synthesized and used as a drug carrier. Poly(MMA-co-HEMA)/MWCNT nanocomposite was also synthesized using an in-situ microemulsion polymerization technique and used as a 5-FU carrier. Different techniques have characterized these groundbreaking drug delivery systems such as FT-IR, XRD, TEM, TGA, zeta potential, and a particle size analyzer. The effects of monomer feed composition, 5-FU content, and MWCNTs content on morphological and structural properties, in-vitro 5-FU release, and entrapment efficiency (EE%) have been studied. It was noted that the inclusion of MWCNTs in the 5-FU-loaded polymer increases the thermal stability and raises the entrapment efficiency (EE%) to hit 99% at CNTs:5-FU ratio of 2:1. The anticancer drug release from the co-polymeric nanospheres depends on the HEMA ratio, 5-FU/copolymer ratio, CNT/5-FU ratio, and the pH of the medium. The optimized nanocomposite demonstrated higher anti-tumor activity against the cell lines CaCo-2, MCF-7, and HepG-2 and higher cytotoxicity against HepG-2 relative to CaCo-2 and MCF-7.

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Encapsulation of Curcumin and Curcumin Derivative in Polymeric Nanospheres

Cited by 18 publications

References 49 publications

Curcumin, Curcumin Nanoparticles and Curcumin Nanospheres: A Review on Their Pharmacodynamics Based on Monogastric Farm Animal, Poultry and Fish Nutrition

Curcumin, Curcumin Nanoparticles and Curcumin Nanospheres: A Review on Their Pharmacodynamics Based on Monogastric Farm Animal, Poultry and Fish Nutrition

Curcumin-Loaded Human Serum Albumin Nanoparticles Prevent Parkinson’s Disease-like Symptoms in C. elegans

Tailoring nano-copolymer/CNTs composite and its application in drug delivery

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