Encapsulation of food bioactives and nutraceuticals by various chitosan-based nanocarriers

Akbari‐Alavijeh, Safoura; Shaddel, Rezvan; Jafari, Seid Mahdi

doi:10.1016/j.foodhyd.2020.105774

Cited by 159 publications

(60 citation statements)

References 123 publications

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“…However, both parameters were not affected effectively when the Cur-CS nanoparticles were prepared with 1 : 0.75 and 1 : 0.5 chitosan : curcumin; there was also no significant difference in the measured mean particle size. Recent studies have demonstrated that curcumin-loaded chitosan nanoparticles produced by the ionic gelation technique exhibited particle sizes within the range of 100 to 500 nm and high encapsulation efficiency (>50%); however, pH sensitivity and high polydispersity are considered as the drawbacks of this method [31,35]. The volume of TPP added during the process to strengthen the covalent bonds between chitosan nanoparticles and curcumin could affect the loading capacity, but several studies have pointed out that TPP has no substantial effect on the loading capacity; rather, it is due to other underlying causes [48,[50][51][52].…”

Section: Resultsmentioning

confidence: 99%

“…Chitosan has gained considerable attention primarily due to its biodegradable, biocompatible, low-toxicity and mucoadhesive properties [33,34]. Chitosan-based nanocarriers including nanoparticles, nanofibers, nanogels, and nanocomposites favour diverse features and characteristics for effective encapsulation of bioactive compounds and nutraceuticals with enhanced bioavailability and stability [35]. Chitosanbased nanoparticles have been employed as a delivery system for insulin, verapamil hydrochloride, small interfering RNAbased drugs, and other hydrophobic drugs by providing various routes of administration, i.e., via ocular, intranasal, and oral routes, and even as an antigen delivery system, they also enhance drug permeability and resistance to the metabolic processes [36][37][38][39].…”

Section: Introductionmentioning

confidence: 99%

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In Vitro Evaluation of Curcumin‐Encapsulated Chitosan Nanoparticles against Feline Infectious Peritonitis Virus and Pharmacokinetics Study in Cats

Selvarajah

Hussein

et al. 2020

BioMed Research International

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Feline infectious peritonitis (FIP) is an important feline viral disease, causing an overridden inflammatory response that results in a high mortality rate, primarily in young cats. Curcumin is notable for its biological activities against various viral diseases; however, its poor bioavailability has hindered its potential in therapeutic application. In this study, curcumin was encapsulated in chitosan nanoparticles to improve its bioavailability. Curcumin-encapsulated chitosan (Cur-CS) nanoparticles were synthesised based on the ionic gelation technique and were spherical and cuboidal in shape, with an average particle size of 330 nm and +42 mV in zeta potential. The nanoparticles exerted lower toxicity in Crandell-Rees feline kidney (CrFK) cells and enhanced antiviral activities with a selective index (SI) value three times higher than that of curcumin. Feline-specific bead-based multiplex immunoassay and qPCR were used to examine their modulatory effects on proinflammatory cytokines, including tumour necrosis factor (TNF)α, interleukin- (IL-) 6, and IL-1β. There were significant decrements in IL-1β, IL-6, and TNFα expression in both curcumin and Cur-CS nanoparticles. Based on the multiplex immunoassay, curcumin and the Cur-CS nanoparticles could lower the immune-related proteins in FIP virus (FIPV) infection. The single- and multiple-dose pharmacokinetics profiles of curcumin and the Cur-CS nanoparticles were determined by high-performance liquid chromatography (HPLC). Oral delivery of the Cur-CS nanoparticles to cats showed enhanced bioavailability with a maximum plasma concentration (Cmax) value of 621.5 ng/mL. Incorporating chitosan nanoparticles to deliver curcumin improved the oral bioavailability and antiviral effects of curcumin against FIPV infection. This study provides evidence for the potential of Cur-CS nanoparticles as a supplementary treatment of FIP.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

In Vitro Evaluation of Curcumin‐Encapsulated Chitosan Nanoparticles against Feline Infectious Peritonitis Virus and Pharmacokinetics Study in Cats

Selvarajah

Hussein

et al. 2020

BioMed Research International

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“…[162][163][164] For example, the chitosanbased antimicrobial films have been widely used as the edible protective coatings for food products owning to chitosan's excellent antimicrobial properties against spoilage microorganisms and pathogenic diseases, e.g., fungi, Gram-negative and Gram-positive bacteria. [162,165,166] Due to their biocompatibility and biodegradability, chitosan-based nano/microencapsulation has been used in drug delivery carriers, vaccines, and biologics. [96,158,[167][168][169][170][171][172] For example, the loading of the antineoplastic agents, e.g., 5-fluorouracil and anti-HIV lamivudine, to chitosan-based nanoparticles can enable controlled drug release in vitro.…”

Section: Chitin and Chitosanmentioning

confidence: 99%

Bio‐Derived Natural Materials Based Triboelectric Devices for Self‐Powered Ubiquitous Wearable and Implantable Intelligent Devices

Yang

Fan

2020

Advanced Sustainable Systems

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The capability of devices in future ubiquitous networked wearable and implantable electronics to efficiently scavenge and store operational power from their working environment through sustainable pathways would enable viable self‐powering schemes in societally‐pervasive applications such as advanced healthcare and robotics. Triboelectric nanogenerators (TENGs) can efficiently harvest the ubiquitous mechanical energy for powering electronics and sensors. However, the majority of demonstrated TENG prototypes have been built with materials that are not biodegradable or biocompatible, which significantly hinders the application of TENGs for wearable and implantable technologies. In this review, the recent progress of the wearable and implantable triboelectric devices built with bio‐derived natural materials is summarized. The properties of these natural biopolymers are discussed in the context of self‐powered triboelectric applications. The common manufacturing methods for processing these materials into triboelectric devices are also discussed. In addition, the applications of the bio‐derived natural materials based TENGs for in vitro and in vivo applications are discussed. Finally, the outstanding challenges and potential opportunities for the development of bio‐derived natural materials based triboelectric devices targeting wearable and implantable human‐integrated applications are analyzed.

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“…A presença desse grupamento amino da quitosana, faz com que em meio ácido (pH <6) ela se solubilize e sofra protonação, podendo nessas condições formar gel (Akbari-Alavijeh et al, 2020). Enquanto que, a presença de ligações do tipo beta 1-4, permite denominá-la como fibra alimentar, uma vez que, a mesma não é hidrolisável no trato gastrointestinal humano pela ausência de enzimas específicas (Hamed et al, 2016;Tang et al, 2020;Naveed et al, 2019).…”

Section: Quitosanaunclassified

Compostos bioativos de interesse para a indústria de alimentos: propriedades, aplicações e perspectivas para o mercado consumidor

Chagas

Santos

Nascimento

et al. 2020

RSD

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Alimentos funcionais são uma tendência de mercado devido a possibilidade de fabricação de produtos processados mais saudáveis, com benefícios à saúde e sensorialmente agradáveis, agregando assim valor aos produtos. Essa pesquisa teve como objetivo revisar as propriedades funcionais dos compostos bioativos β-glucanas, inulina, psyllium, quitosana e licopeno, demonstrando as possibilidades de utilização pela indústria de alimentos no desenvolvimento de novos produtos, apresentando suas composições, aplicações tecnológicas e características funcionais. Tais compostos bioativos possuem grandes possibilidades de uso em produtos da panificação, produtos lácteos, cárneos e bebidas. Do ponto de vista tecnológico, a indústria de alimentos brasileira pode explorar suas aplicações na reformulação de produtos mais saudáveis, com diferentes texturas e apelos de mercados.

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Encapsulation of food bioactives and nutraceuticals by various chitosan-based nanocarriers

Cited by 159 publications

References 123 publications

In Vitro Evaluation of Curcumin‐Encapsulated Chitosan Nanoparticles against Feline Infectious Peritonitis Virus and Pharmacokinetics Study in Cats

In Vitro Evaluation of Curcumin‐Encapsulated Chitosan Nanoparticles against Feline Infectious Peritonitis Virus and Pharmacokinetics Study in Cats

Bio‐Derived Natural Materials Based Triboelectric Devices for Self‐Powered Ubiquitous Wearable and Implantable Intelligent Devices

Compostos bioativos de interesse para a indústria de alimentos: propriedades, aplicações e perspectivas para o mercado consumidor

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