Encapsulation of L-ascorbic acid via polycaprolactone-polyethylene glycol-casein bioblends

Abstract

The aim of this study was to encapsulate, L-ascorbic acid, in biopolymers in order to obtain (i) enhancing its encapsulation effi ciency (ii) increasing drug release ratio using different pH mediums. Microparticles based on polycaprolactone, polyethylene glycol and casein are prepared by spray drying technique. Microparticles are in vitro characterized in terms of yield of production, particle size, morphology, encapsulation efficiency, and drug release. In this manner, the importance of the study is producing of a stable and effective drug encapsulation system by PCL-PEG-CS polymer mixture by spray dryer. We achieved minimum 27.540±0.656 μm particle size with 0.512 m 2 /g surface area, 84.05% maximum drug loading, and 68.92% drug release ratio at pH 9.6. Release profi les are fi tted to previously developed kinetic models to differentiate possible release mechanisms. The Korsmeyer-Peppas model is the best described each release scenario, and the drug release is governed by non-Fickian diffusion at pH 9.6. Our study proposed as an alternative or adjuvants for controlling release of L-ascorbic acid.

Ecotoxicity evaluation of polymeric nanoparticles loaded with ascorbic acid for fish nutrition in aquaculture

“…The release constant (k) for vitamin C released from chitosan nanoparticles at pH 7.4 and pH 3 were 1.0 and 1.4 min −1 respectively [ 32 ]. In other hand, when the release rate of vitamin C was evaluated from polycaprolactone-polyethylene glycol microparticles in three different pH (2.8, 7.4 and 9.6), the obtained values were between 0.0127 to 0.0493 min −1 [ 33 ]. In this way, the results found here corroborate with previous published results in the literature, where the release rate of AA is faster when encapsulated into chitosan nanoparticles in comparison to PCL nanoparticles.…”

Pasture A2-β Pure Milk Marketing Strategy

“…Research at home and abroad for the research of this paper provides the theoretical foundation and the basis, this study used questionnaire survey on pasture A2-β casein pure milk market research as well as the consumers' attitude toward research, market research is mainly aimed at the milk market capacity and market competition, consumers' attitude toward research main statistical analysis of the types and specific performance, to lay the foundation for the establishment of marketing strategy [5]. Using the SWOT analysis method to A2-β casein marketing environment of pure milk, given a certain marketing strategy, control experiment method was used to study the traditional marketing strategy and marketing strategy in increasing consumer purchasing power, optimization of pasture image, expand the pure milk market influence, and the similarities and differences between consumers' attitude, according to the results to determine whether marketing strategy of this paper have feasibility, aimed at our country A2-β casein pure milk marketing to provide the reference [6].…”