Encapsulation of nanoparticles using linear–dendritic macromolecules

Namazi, Hassan; Adeli, Mohsen; Zarnegar, Zohre; Jafari, Sevda; Dadkhah, Abbas; Shukla, Anuj

doi:10.1007/s00396-007-1717-6

Cited by 55 publications

(23 citation statements)

References 42 publications

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“…Further, citric acid, as used herein, is more readily available and of lower cost than sebacic acid. In regards to polymers based on citric acid, other papers have described reacting citric acid with polyethylene glycol to create thermoplastic tri‐block dendrimer macromolecules and nanomolecules for drug delivery systems; however, these polymers showed limited biodegradability . Also the thermoplastic materials would have minimal branching, and therefore only modest mechanical property change, as compared to the high crosslinking potential of the described thermoset materials.…”

Section: Introductionmentioning

confidence: 99%

“…For the first two properties, the use of nontoxic, pharmaceutical grade, ester bond‐forming components, we identified citric acid and glycerol (listed as one of top 12 renewable chemicals by the United States Department of Energy) as nontoxic renewable resources and biologically safe nutrients, being generally regarded as safe (GRAS) by the United States Food and Drug Administration . Both have been identified as building blocks for a platform to deliver pharmaceuticals . For the third desired property, the rate of degradation has been found to be inversely proportional to the amount of crosslinking, and it is possible to vary the amount of crosslinking of citric acid and glycerol.…”

Section: Introductionmentioning

confidence: 99%

“…In regards to polymers based on citric acid, other papers have described reacting citric acid with polyethylene glycol to create thermoplastic tri-block dendrimer macromolecules and nanomolecules for drug delivery systems; however, these polymers showed limited biodegradability. [16][17][18][19] Also the thermoplastic materials would have minimal branching, and therefore only modest mechanical property change, as compared to the high crosslinking potential of the described thermoset materials. Finally, citric acid was previously reacted with glycerol in solution and in the presence of benzene and ptoluenesulfonic acid (PTSA) to form a crosslinked ester copolymer.…”

Section: Introductionmentioning

confidence: 99%

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A biodegradable thermoset polymer made by esterification of citric acid and glycerol

Halpern

Urbanski

Weinstock

et al. 2013

J Biomedical Materials Res

128

110

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A new biomaterial, a degradable thermoset polymer, was made from simple, economical, biocompatable monomers without the need for a catalyst. Glycerol and citric acid, non-toxic and renewable reagents, were crosslinked by a melt polymerization reaction at temperatures from 90-150°C. Consistent with a condensation reaction, water was determined to be the primary byproduct. The amount of crosslinking was controlled by the reaction conditions, including temperature, reaction time, and ratio between glycerol and citric acid. Also, the amount of crosslinking was inversely proportional to the rate of degradation. As a proof-of-principle for drug delivery applications, gentamicin, an antibiotic, was incorporated into the polymer with preliminary evaluations of antimicrobial activity. The polymers incorporating gentamicin had significantly better bacteria clearing of Staphylococcus aureus compared to non-gentamicin gels for up to nine days.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A biodegradable thermoset polymer made by esterification of citric acid and glycerol

Halpern

Urbanski

Weinstock

et al. 2013

J Biomedical Materials Res

128

110

View full text Add to dashboard Cite

show abstract

“…This work, based on our previous investigations, reports synthesis of carbosiloxanbased dendritic macromolecules by using the hydrosilylation-alcoholysis methodology. [23][24][25][26][27] PEO was chosen because of its distinguished effects on biocompatibility and solubility of copolymers especially in the field of bioapplications. 28 To establish this system as a suitable carrier, micellar properties of the dendritic amphiphilic copolymers in aqueous media were studied by fluorescence techniques and dynamic light scattering.…”

Section: Introductionmentioning

confidence: 99%

Hybrid organic/inorganic dendritic triblock copolymers: Synthesis, nanostructure characterization, and micellar behavior

Namazi

Jafarirad

2010

J of Applied Polymer Sci

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A new class of amphiphilic dendritic ABA triblock copolymers, which is based on organic linear polyethylene oxide (PEO) and inorganic dendritic carbosiloxane (CSO) was synthesized. The strategy used in synthesizing these materials is based on divergent method using hydrosilylation-alcoholysis cycles. The reaction conditions and structural features of dendrimers were analyzed by different physicochemical techniques such as: GPC, NMR, UV spectroscopy, DSC, and viscometry. The generational limit of dendrimer after the first generation, OSC-D G 1 -PEO-D G 1 -CSO, forced us to employ HSiCl 2 CH 3 as branching reagent. Also further hydrosilylation of the third generation yielded an irregular structure species. Self-assembling and morphological studies of first, OSC-D G 1 -PEO-D G 1 -CSO, and second, OSC-D G 2 -PEO-D G 2 -CSO, generations in aqueous medium were monitored by using fluorescence, TEM and DLS techniques. However, the dendritic block copolymer with third generation, OSC-D G 3 -PEO-D G 3 -CSO, could not be dispersed in aqueous phase. The diameters of denderitic micelles had a narrow distribution in the ranges of 69 and 88 nm, respectively. Although the micelles were stable even in first generation, partition equilibrium constants of pyrene and critical micelle concentration in both of dendritic micelles imply that the micellar behaviors of the supramolecules strongly depend on the hydrophobic block's size in which increasing generation effectively promoted the micelle formation.

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“…For example attachment of dendritic moieties to linear macromolecules provides a possibility to improve their functionality and three-dimensional structures. [1][2][3][4][5][6][7][8][9][10][11] Dendrimers are interesting class of highly branched macromolecules that comprise a central core, branches expanded from the core and many surface or terminal groups, and three-dimensional features that resemble the architecture of a tree. These radial polymers have specific and systematically variable size, shape and chemical structures.…”

Section: Introductionmentioning

confidence: 99%

Hybrid Nanomaterials Containing Pamam, Polyrotaxane and Quantum Dot Blocks

Adeli

Sarabi

Sadeghi

2011

NANO

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Pseudopolyrotaxanes, Ps-PR, consisting of α-cyclodextrin rings, polyethylene glycol axes and end triazine groups were prepared and then were capped by amino-functionalized quantum dots, NH 2 -QDs, to achieve polyrotaxanes. The amino-functionalized QDs stoppers of polyrotaxanes were used as core to synthesize polyamidoamine, PAMAM, dendrons divergently and hybrid nanomaterials were obtained. Synthesized hybrid nanomaterials were characterized by different spectroscopy, microscopy and thermal analysis methods. They were freely soluble in water and their aqueous solutions were stable at room temperature over several months. Due to their biocompatible backbone, high functionality and water solubility synthesized hybrid nanomaterials are promising carriers and probes in cancer diagnosis and therapy.

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Encapsulation of nanoparticles using linear–dendritic macromolecules

Cited by 55 publications

References 42 publications

A biodegradable thermoset polymer made by esterification of citric acid and glycerol

A biodegradable thermoset polymer made by esterification of citric acid and glycerol

Hybrid organic/inorganic dendritic triblock copolymers: Synthesis, nanostructure characterization, and micellar behavior

Hybrid Nanomaterials Containing Pamam, Polyrotaxane and Quantum Dot Blocks

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