Encapsulation of resveratrol in zein/pectin core-shell nanoparticles: Stability, bioaccessibility, and antioxidant capacity after simulated gastrointestinal digestion

Huang, Xulin; Liu, Ye; Zou, Yan; Liang, Xiao; Peng, Yaqi; McClements, David Julian; Hu, Kun

doi:10.1016/j.foodhyd.2019.02.039

Cited by 191 publications

(106 citation statements)

References 50 publications

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“…Reducing the pH and temperature and limiting exposure to oxygen and light could therefore improve the stability of trans ‐resveratrol in liquid dosage . When resveratrol was loaded by zein–pectin core / shell nanoparticles, they became stable to aggregation from pH 2 to 7 and exhibited good heat stability . Similar results were obtained by other groups .…”

Section: Stabilitysupporting

confidence: 76%

Resveratrol: a review of plant sources, synthesis, stability, modification and food application

2019

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Resveratrol, a stilbene molecule belonging to the polyphenol family, is usually extracted from a great many natural plants. The technologies of preparation and extraction methods are developing rapidly. As resveratrol has many beneficial properties, it has been widely utilized in food and medicine industry. In terms of its structure, it is susceptible to degradation and can undergo chemical changes during food processing. Different studies have therefore given more attention to various aspects of resveratrol, including anti-aging, anti-oxidant, and anti-cancer activity. This review classifies the study of resveratrol, considers plant sources, synthesis, stability, common reactions, and food applications, and provides references to boost its food and medical utilization. SYNTHESISSince the discovery of natural resveratrol by researchers, chemist have made many attempts at the chemical synthesis / biosynthesis of resveratrol (Fig. 2). 15

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Section: Stabilitysupporting

confidence: 76%

Resveratrol: a review of plant sources, synthesis, stability, modification and food application

2019

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“…RES has been previously reported to have anti-cancer effects on prostate cancer cell lines LNCaP, DU145, and PC3 (Athar et al, 2009; Cimino et al, 2012). Although, RES offers many benefits its effectiveness is decreased by its low bioavailability and serum stability (De Vries et al, 2018; Huang et al, 2019; Tabibiazar et al, 2019). Many drug delivery systems including nanoparticles have been used in order to improve its stability, bioavailability and targetability (Summerlin et al, 2016; Huang et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Encapsulation and Controlled Release of Resveratrol Within Functionalized Mesoporous Silica Nanoparticles for Prostate Cancer Therapy

Chaudhary

Subramaniam

Khan

et al. 2019

Front. Bioeng. Biotechnol.

111

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Resveratrol (RES) is a naturally existing polyphenol which exhibits anti-oxidant, anti-inflammatory, and anti-cancer properties. In recent years, RES has attracted attention for its synergistic effect with other anti-cancer drugs for the treatment of drug resistant cancers. However, RES faces the issues of poor pharmacokinetics, stability and low solubility which limits its clinical application. In present study, RES has been loaded onto uniformly sized (~60 nm) mesoporous silica nanoparticles (MSNs) to improve its in vitro anti-proliferative activity and sensitization of Docatexal in hypoxia induced drug resistance in prostate cancer. RES was efficiently encapsulated within phosphonate (negatively charged) and amine (positively charged) modified MSNs. The effect of surface functionalization was studied on the loading, in vitro release, anti-proliferative and cytotoxic potential of RES using prostate cancer cell line. At pH 7.4 both free and NH2-MSNs loaded RES showed burst release which was plateaued with almost 90% of drug released in first 12 h. On the other hand, PO3-MSNs showed significantly slower release kinetics with only 50% drug release in first 12 h at pH 7.4. At pH 5.5, however, both the PO3-MSNs and NH2-MSNs showed significant control over release (around 40% less release compared with free RES in 24 h). Phosphonate modified MSNs significantly enhanced the anti-proliferative potential of RES with an IC50 of 7.15 μM as compared to 14.86 μM of free RES whereas amine modified MSNs didn't affect proliferation with an IC50 value higher than free RES (20.45 μM). Furthermore, RES loaded onto PO3-MSNs showed robust and dose dependent sensitization of Docatexal in hypoxic cell environment which was comparable to pure RES solution. This study provides an example of applicability of MSNs loaded with polyphenols such as RES as next generation anticancer formulations for treating drug resistant cancers such as prostate cancer.

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“…Pectin (Huang et al, 2017;Huang et al, 2019) pH-Induced antisolvent precipitation Spherical core-shell Curcumin Resveratrol…”

Section: Chitosan Andmentioning

confidence: 99%

“…In the differential scanning calorimetry profiles, there was no evidence of a sharp endothermic peak around 177°C , which was the peak of pure curcumin, suggesting that curcumin was in an amorphous form in ZPNs. Huang et al encapsulated resveratrol into ZPNs in the same way (Huang et al, 2017(Huang et al, , 2019. The results showed that encapsulated resveratrol had a good in vitro antioxidant and anticancer properties and higher bioaccessiblility than free resveratrol.…”

Section: Pectinmentioning

confidence: 99%

Development of a nanoparticle delivery system based on zein/polysaccharide complexes

2020

Journal of Food Science

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Zein, an alcohol-soluble protein in corn, can self-assemble into spherical nanoparticles, which makes it an ideal carrier material for the encapsulation of hydrophobic bioactive molecules. However, zein nanoparticles easily aggregate in water and are sensitive to enzymatic degradation in the digestive system. A strategy to overcome their limitations is the incorporation of polysaccharides as a second polymer layer that provides stability to zein nanoparticles. This review introduces the characteristics of zein as they relate to understanding the formation of zein/polysaccharide nanoparticles. Particular attention is paid to the preparation methods for the zein/polysaccharide nanoparticles, as well as to the morphological observation methods and detection mechanism. Moreover, the properties and applications of zein/polysaccharide nanoparticles are highlighted.

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Encapsulation of resveratrol in zein/pectin core-shell nanoparticles: Stability, bioaccessibility, and antioxidant capacity after simulated gastrointestinal digestion

Cited by 191 publications

References 50 publications

Resveratrol: a review of plant sources, synthesis, stability, modification and food application

Resveratrol: a review of plant sources, synthesis, stability, modification and food application

Encapsulation and Controlled Release of Resveratrol Within Functionalized Mesoporous Silica Nanoparticles for Prostate Cancer Therapy

Development of a nanoparticle delivery system based on zein/polysaccharide complexes

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