Encapsulation of the anticancer drug cisplatin into nanotubes

Simple mixing and hot pressing methods were used to make composites from home waste-in particular, paper and dry leaves-using polyvinyl acetate (PVAc) as an adhesive and silica nanoparticles as filler. The optimum composition for the strongest composites, in terms of compressive strength, had a mass ratio of silica nanoparticles/ PVAc/(paper ? dry leaves) of 3:80:280. With this mass ratio, a compressive strength of 68.50 MPa was obtained for samples prepared at a pressing temperature of 150°C, pressing pressure of 100 MPa, and pressing time of 20 min. The addition of silica nanoparticles increased the compressive strength by about 50%, compared with composites made without the addition of nanosilica (45.60 MPa). Higher compressive strength was obtained at a higher pressing pressure. At a pressing pressure of 120 MPa, pressing temperature of 150°C, and pressing time of 20 min, a compressive strength of 69.10 MPa was obtained. When the pressing time was increased to 45 min at a pressing pressure of 120 MPa, a compressive strength of 84.37 MPa was measured. A model was also proposed to explain the effects of pressing pressure and pressing time on compressive strength. The model predictions were in good agreement with the experimental data.

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“…For this purpose, we performed the following calculations. Hilder and Hill [13] expressed the Lennard-Jones potential as U = -A/r 6 ? B/r 12 .…”

Section: Resultsmentioning

confidence: 99%

High compressive strength of home waste and polyvinyl acetate composites containing silica nanoparticle filler

Masturi

Abdullah

Khairurrijal

2011

J Mater Cycles Waste Manag

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“…Various purification processes have been reported to separate metallic and semiconducting SWCNT mixtures, such as electrophoresis, centrifugation, chromatography, and solubilisation [55][56][57]. However, purification of semiconducting SWNTs can add considerable time and resources to the production process [56], and as CNT-FET device for biosensing using antibody receptors (reproduced with permission from [22]); (c) Electrochemical sensor for glucose consisting of an Au electrode bonded to a CNT-GO x which detects redox reactions between FAD and glucose (reproduced with permission from [51]); (d) "basket-like" periodic MWNT lattices into which mice fibroblast is to be implanted (reproduced with permission from [52]); (e) alginate-polylysinealginate microcapsule destruction by the photoacoustic effect by folate acid-functionalized SWNTs inside the cells (reproduced with permission from [53]); (f) loading and unloading of molecules inside CNTs for drug delivery; drugs are released when a CNT is uncapped within the cytoplasm of the cell (reproduced with permission from [54]).…”

Section: Carbon Nanotubes For Biosensing the Incorporation Ofmentioning

confidence: 99%

“…Secondly, each CNT can be functionalized to detect and interact with a single cell, improving the delivery efficiency and reducing the drug dosage [17,116]. It has been demonstrated that 5 million species can be bonded to an 80 nm long CNT [54]. The combination of size and ease of functionalization allows CNT to deliver drugs to cells, such as neurons and cardiomyocytes, which are difficult to reach by traditional drug-delivery methods [117].…”

Section: Carbon Nanotubes In Drug Deliverymentioning

confidence: 99%

“…The combination of size and ease of functionalization allows CNT to deliver drugs to cells, such as neurons and cardiomyocytes, which are difficult to reach by traditional drug-delivery methods [117]. Lastly, drugs can be encapsulated into CNTs [54,[118][119][120], where release of the drug in the desired cell compartment requires the chemical disintegration of the CNT cap, as illustrated in Figure 2(f) [22]. Successful examples include anticancer drugs and IRemitting molecules for direct heat treatment in vivo [121].…”

Section: Carbon Nanotubes In Drug Deliverymentioning

confidence: 99%

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Applications and Nanotoxicity of Carbon Nanotubes and Graphene in Biomedicine

Fisher

Rider

Han

et al. 2012

Journal of Nanomaterials

137

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Owing to their unique mechanical, electrical, optical, and thermal properties, carbon nanostructures including carbon nanotubes and graphenes show great promise for advancing the fields of biology and medicine. Many reports have demonstrated the promise of these carbon nanostructures and their hybrid structures (composites with polymers, ceramics, and metal nanoparticles, etc.) for a variety of biomedical areas ranging from biosensing, drug delivery, and diagnostics, to cancer treatment, tissue engineering, and bioterrorism prevention. However, the issue of the safety and toxicity of these carbon nanostructures, which is vital to their use as diagnostic and therapeutic tools in biomedical fields, has not been completely resolved. This paper aims to provide a summary of the features of carbon nanotube and graphene-based materials and current research progress in biomedical applications. We also highlight the current opinions within the scientific community on the toxicity and safety of these carbon structures.

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“…Furthermore, the changes occurring in the molecular geometrical structure and the thermodynamic stability when it is confined inside the hollow space of capped nanotubes SWCNT(12,0), SWCNT (14,0), and SWCNT(16,0) by considering mainly the van der Waals interaction have been investigated. This study is performed to predict the encapsulation of this molecule into carbon nanotubes; the long-term objective is to perform a targeted delivery of this molecule in cancer cells following the model proposed by Hilder et al [29]. In this study, the molecular structure analysis of the studied molecule has been performed in gas phase and aqueous solution by a DFT method and inside the nanotube cavity by an ONIOM(DFT:MM) method.…”

Section: Introductionmentioning

confidence: 99%

Computational Studies on the Molecule 1-(2-Hydroxyethyl)-5-Fluorouracil in Gas Phase and Aqueous Solution and Prediction of Its Confinement inside Capped Nanotubes

Assatse

Ejuh

Tchoffo

et al. 2019

Advances in Condensed Matter Physics

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Density functional theory (DFT) calculations were performed on a fluorouracil derivative at the B3LYP/6−31+G(d) level. Furthermore, the ONIOM method was performed to investigate the possibility of its confinement inside capped nanotubes. The results found of the structural parameters of the optimized molecule are in good agreement with experimental data. The analysis of thermodynamic properties leads us to predict that the confinement of the studied molecule inside capped nanotubes SWCNT(12,0), SWCNT(14,0), and SWCNT(16,0) is possible. The large values found suggest a good stability for the studied molecule. The predicted nonlinear optical (NLO) properties of the studied molecule are much greater than those of urea. Thereby, it is a good candidate as second-order NLO material. The calculated û values suggest that the studied molecule is more soluble than the 5-FU molecule. The results of quantum molecular descriptors show that the studied molecule is hard electrophile and strongly reactive.

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Encapsulation of the anticancer drug cisplatin into nanotubes

Cited by 12 publications

References 31 publications

High compressive strength of home waste and polyvinyl acetate composites containing silica nanoparticle filler

High compressive strength of home waste and polyvinyl acetate composites containing silica nanoparticle filler

Applications and Nanotoxicity of Carbon Nanotubes and Graphene in Biomedicine

Computational Studies on the Molecule 1-(2-Hydroxyethyl)-5-Fluorouracil in Gas Phase and Aqueous Solution and Prediction of Its Confinement inside Capped Nanotubes

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