Encapsulation of the flavonoid quercetin with an arsenic chelator into nanocapsules enables the simultaneous delivery of hydrophobic and hydrophilic drugs with a synergistic effect against chronic arsenic accumulation and oxidative stress

Ghosh, Swarupa; Dungdung, Sandhya Rekha; Chowdhury, Somsubhra Thakur; Mandal, Ardhendu; Sarkar, Siddik; Ghosh, Dibakar; Das, Nirmalendu

doi:10.1016/j.freeradbiomed.2011.08.019

Cited by 65 publications

(36 citation statements)

References 38 publications

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“…These include N-acetylcysteine (Bao and Shi 2010a), alpha-lipoic acid, vitamin C and E, taurine, quercetin (Ghosh et al 2011), some plant extracts including garlic (Balakumar and Kaur 2009;Biswas et al 2010;Flora 2011), and resveratrol (Zhao et al 2008b;Zhang et al 2012b). …”

Section: Endothelial Dysfunction: the Link Between As And CV Disease?mentioning

confidence: 99%

Cardiovascular effects of arsenic: clinical and epidemiological findings

Stea

Bianchi

Cori

et al. 2013

Environ Sci Pollut Res

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Section: Endothelial Dysfunction: the Link Between As And CV Disease?mentioning

confidence: 99%

Cardiovascular effects of arsenic: clinical and epidemiological findings

Stea

Bianchi

Cori

et al. 2013

Environ Sci Pollut Res

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“…The mode of action of arsenic-induced genotoxicity is quite complicated. However, oxidative stress is currently the most widely accepted and studied mechanism of arsenic toxicity [8]. A number of studies showed arsenic-induced formation of reactive oxygen species (ROS) and reactive nitrogen species as well as elevated DNA oxidation [9].…”

Section: Introductionmentioning

confidence: 99%

Protective action of curcumin and nano-curcumin against arsenic-induced genotoxicity in rats in vivo

et al. 2014

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We explored whether nanoformulation of curcumin can cause better protective effect than free curcumin against arsenic-induced genotoxicity. Curcumin-loaded Poly(lactic-co-glycolic acid) nanoparticles (CUR-NP) were prepared by emulsion technique. The CUR-NP were water soluble and showed biphasic release pattern. Rats were divided into 5 groups of 6 each. Group I served as the control. Group II rats were exposed to sodium arsenite (25 ppm) daily through drinking water for 42 days. Groups III, IV and V were maintained as in Group II, however, they were also administered empty nanoparticle, curcumin (100 mg/kg bw) and CUR-NP (100 mg/kg bw), respectively, by oral gavage during the last 14 days of arsenic exposure. On the 43rd day, genotoxic effects were evaluated in bone marrow cells. Arsenic increased chromosomal aberrations, micronuclei formation and DNA damage. Both free curcumin and CUR-NP attenuated these arsenic-mediated genotoxic effects. However, the result suggests that nanoformulation have better protective effect than free curcumin at the same dose level.

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“…The ability to quench singlet oxygen seems to be in relation with the chemical structure of catechin, with the presence of the catechol moiety on ring B and the presence of a hydroxyl group activating the double bond on ring C [13]. In a similar study, researchers from our laboratory have reported the synergistic effect of chelator and antioxidant drug into nanocapsule against chronic arsenic toxicity and stress induced oxidative damage [7]. The combinatorial therapy could also be effectively circumvented blood brain barrier in brain and mucosal barrier in gastrointestinal tract, leads to significant achievement in drug delivery system.…”

Section: Bioavailability Of Npch and Npsmbmentioning

confidence: 80%

“…However poor water solubility and limited oral bioavailability are the major roadblocks in its development as a therapeutic agent for cancer and other chronic diseases. Previous report has already established the potency of combined therapy by chelator and antioxidant drug to prevent arsenic induced chronic toxicity in rats [7]. Hence an improved combinatorial delivery mode for (+)-Catechin hydrate and sodium metaborate could be expected as an effective approach to reduce fluoride induced oxidative stress.…”

Section: Introductionmentioning

confidence: 99%

Formulation of Catechin Hydrate Nanocapsule and Study of its Bioavailability

Samanta¹,

Bidyut²,

yopadhyay³

et al. 2016

Med chem (Los Angeles)

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Flavonoid is a polyphenolic antioxidant used to treat free radical mediated tissue damage. So flavonoids are the good targets for treatment of many diseases like cancer, toxicity health hazards, neurodegenaration etc. Drug delivery of flavonoid is the novel approach where dosing and drug toxicity can be minimized. Antioxidant Catechin Hydrate (CH) is choosen to make drug delivery vehicle: nanocapsules either alone or in combination with chelator sodium meta borate (SMB) within biodegradable poly-lactide-co-glycolide (PLGA). Sizes of the prepared particles were determined through scanning and atomic force microscopy where less than 50 nm particle sizes were revealed. Bioavailability in serum study determines that shelf life of CH can be increased with nanocapsule delivery compared to free drug. Results demonstrate the efficacy of Nanocapsulated CH to be a potent vehicle for tissue targeting.

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Encapsulation of the flavonoid quercetin with an arsenic chelator into nanocapsules enables the simultaneous delivery of hydrophobic and hydrophilic drugs with a synergistic effect against chronic arsenic accumulation and oxidative stress

Cited by 65 publications

References 38 publications

Cardiovascular effects of arsenic: clinical and epidemiological findings

Cardiovascular effects of arsenic: clinical and epidemiological findings

Protective action of curcumin and nano-curcumin against arsenic-induced genotoxicity in rats in vivo

Formulation of Catechin Hydrate Nanocapsule and Study of its Bioavailability

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