Encephalic Leukocytoclastic Vasculitis during Treatment with Sunitinib for Renal Cell Carcinoma: A Case Report

Massucci, Maria; Mollica, Veronica; Rizzo, Alessandro; Ventrella, Laura; Maggio, Ilaria; Manuzzi, Lisa; Gatto, Lidia; Brandi, Giovanni; Massari, Francesco

doi:10.3390/medicines8010005

Cited by 2 publications

(1 citation statement)

References 16 publications

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“…PNS vasculitis is more frequently associated with hematologic malignancies [8,9], with less common association with solid tumors [8,9]. As a result, most of the studies on PNS vasculitis in solid tumors are case reports or small series of patients [2,3,8,[10][11][12][13][14]. PNS vasculitis in RCC has only been reported in a few case reports, where treatment of RCC and PNS vasculitis was with nephrectomy [2,8,10,15,16].…”

Section: Discussionmentioning

confidence: 99%

Stereotactic Radiotherapy in the Treatment of Paraneoplastic Vasculitis in Oligometastatic Renal Cell Carcinoma

et al. 2021

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Approximately 20% of renal cell carcinoma (RCC) is diagnosed because of paraneoplastic manifestations. RCC has been associated with a large variety of paraneoplastic syndromes (PNS), but it is rarely associated with PNS vasculitis. We present a case of a previously healthy male who presented with systemic vasculitis; bitemporal headaches, diplopia, polyarthritis, palpable purpura, tongue lesion, peri-orbital edema, scleritis, chondritis and constitutional symptoms. He was subsequently found to have oligometastatic RCC. Both his primary lesion and site of oligometastasis were treated with stereotactic radiotherapy (SBRT) and resulted in the resolution of his vasculitis, as well as sustained oncologic response. This is the first case to demonstrate that effective sustained treatment for PNS vasculitis due to oligometastatic RCC is possible with SBRT.

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Section: Discussionmentioning

confidence: 99%

Stereotactic Radiotherapy in the Treatment of Paraneoplastic Vasculitis in Oligometastatic Renal Cell Carcinoma

et al. 2021

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Sunitinib-Induced Cutaneous Small-Vessel Vasculitis: A Rare Case Report

et al. 2022

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Introduction: Sunitinib is an inhibitor of tumor angiogenesis and has been used as the first-line drug in metastatic renal cell carcinoma (RCC). Sunitinib attracts attention due to its cutaneous toxicities, which are unusual but can range from benign self-resolving skin rash to severe systemic involvement. Herein, we report a 51-year-old male case with metastatic RCC, clear cell type. Case Presentation: Due to multifocal metastatic disease, the patient was started on tablet sunitinib 50 mg once daily (2 weeks on and 1 week off protocol) with palliative intent. On the 4th day of the second cycle, the case developed multiple reticulate palpable purpuric lesions over bilateral shins without any other constitutional or systemic symptoms, such as fever, joint pain, or abdominal pain. Skin histopathology was consistent with clinical suspicion of cutaneous small-vessel vasculitis. The potential involvement of other organs was ruled out. The lesions resolved completely within 2 weeks through symptomatic treatment with topical fluocinolone acetonide 0.01% cream and emollients. Conclusions: Sunitinib was continued uninterrupted without other organ involvement or the reappearance of lesions. Therefore, oncology care providers should always be vigilant and thoroughly evaluate any cutaneous toxicities associated with sunitinib, although it is a rare manifestation.

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Encephalic Leukocytoclastic Vasculitis during Treatment with Sunitinib for Renal Cell Carcinoma: A Case Report

Cited by 2 publications

References 16 publications

Stereotactic Radiotherapy in the Treatment of Paraneoplastic Vasculitis in Oligometastatic Renal Cell Carcinoma

Stereotactic Radiotherapy in the Treatment of Paraneoplastic Vasculitis in Oligometastatic Renal Cell Carcinoma

Sunitinib-Induced Cutaneous Small-Vessel Vasculitis: A Rare Case Report

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