Encephalopathy Due to Short- and Medium-Chain Fatty Acids

Zieve, Leslie

doi:10.1007/978-1-4684-1209-3_7

Cited by 13 publications

(1 citation statement)

References 31 publications

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“…It was surprising that although brain concentrations of NE decrease while brain concentrations of DA increase in the HEP rats, releases of both catecholamines tended to increase. Possible factors underlying these increased releases could be increased concentrations of ammonia (Tyee et al, 1971), a toxin with multiple effects in brain (Butterworth, 1991), or increases in free fatty acids (Zieve, 1985), which have been shown to have multiple effects on membranes (Cumar et at., 1980) and also to increase overflow of DA and of some amino acids (Rhoads et al, 1983).…”

Section: Releases Of Ne Da and Metabolites: Changes After Hepatectomentioning

confidence: 99%

Releases of Norepinephrine and Dopamine in Ventriculocisternal Perfusions in Hepatectomized and Laparotomized Rats

McKinzie

Hammond

Grabau

et al. 1996

Journal of Neurochemistry

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The completely hepatectomized rat has frequently been used as a model to study changes in the economy of norepinephrine (NE) and dopamine (DA) in hepatic coma. Hypothermia characteristically develops in hepatectomized rats and also occurs in patients in hepatic coma and is associated with improved survival in both. The aims of the present study were to measure both release and uptake of NE and release of DA in brain in warm (37°C) and cool (30–32°C) rats at 3–5 h after laparotomy or hepatectomy. Ventriculocisternal perfusions of the brain were performed on rats under basal conditions and during releases evoked by 40 mM K+. Basal releases of NE and DA and evoked release of DA were greater in the warm hepatectomized rats than in all other groups. In some studies, 10−5M amitriptyline was added to the perfusates to assess whether neuronal uptake was changed after hepatectomy. Uptake of released NE was equally robust in cool hepatectomized as in cool laparotomized rats but could not be measured in warm hepatectomized rats because of amitriptyline toxicity in these rats. Decreases in NE and increases in DA content were found in most areas of the brain after perfusion. Increased releases of NE and DA may contribute to the pathogenesis of hepatic encephalopathy.

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Section: Releases Of Ne Da and Metabolites: Changes After Hepatectomentioning

confidence: 99%