Encephaloradiculomyelitis associated to HHV-7 and CMV co-infection in immunocompetent host

Meningomielitis asociadas a infección por herpes virus humano 7: Comunicación de dos casos

“…Ginanneschi y cols. comunicaron el año 2007 también la infección concomitante de VHH-7 con citomegalovirus en un paciente inmunocompetente que debutó con mielitis 4 . Se estima que 90% de los adultos son seropositivos para HHV-7.…”

“…Posteriormente se ha descrito por Ginanneschi y cols. un paciente inmunocompetente con mielitis y con infección concomitante por citomegalovirus 4 . En nuestro conocimiento, no existen en la literatura más de 3 casos comunicados y ninguno en hispanoamérica de compromiso del SNC por VHH-7.…”

A Systemic and Severe Infection via Cytomegalovirus and Other Herpesviruses in a Young Apparently Immunocompetent Patient: A Case Report

“…Noteworthy, the polymerase chain reaction analysis, which is a highly sensitive investigation for viral infection diagnosis and viral load monitoring, was positive for CMV and for four other herpesviruses, namely EBV, HHV-6, HHV-7 and HHV-8. Literature data report very few cases of herpesvirus co-infections in healthy immunocompetent individuals, mainly consisting in simultaneous EBV/CMV infection [21], while CMV/HHV-7 co-infection has been found to occur only in one case, manifesting as encephaloradiculomyelitis [22]. Moreover, a triple and asymptomatic infection of EBV/CMV/HHV-6, albeit uncommon, was reported in apparently healthy individuals aged ≥ 17 years [23].…”

4-Hydroxy-2-quinolones 139. Synthesis, structure, and antiviral activity of N-R-amides of 2-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acids

“…Cytomegalovirus, little studied at present, herpes type 5, affects the nervous system and human internal organs [9,10]. An etiological link, not without basis, is proposed for herpes type 6 and encephalitis [7,11], and for type 7 with chronic fatigue syndrome [7,9,10], called in mass information media "the plague of the 21 st century". Kaposi sarcoma, associated with HIV infection and AIDS, is also caused by herpes virus, but of type 8 [6,12].…”

“…1, Tables 3 and 4). It was established that all the non-hydrogen atoms of its pyridinopyrimidine bicycle and also the O (1) , C (9) , O (3) , N (3) , C (10) , O (2) , and C (16) atoms lie in one plane with a precision of 0.02 Å, which is probably caused by the presence of two strong intramolecular hydrogen bonds: O (1) -H (10) ···O (3) (H···O 1.56 Å, O-H···O 158 o ) and N (3) -H (3N) ···O (2) (H···O 1.95 Å, N-H···O 136°). The formation of the indicated hydrogen bonds leads to a significant redistribution of electron density in the pyrimidone fragment.…”