Encoded Silica Colloidal Crystal Beads as Supports for Potential Multiplex Immunoassay

Zhao, Yuanjin; Zhao, Xiangwei; Sun, Cheng; Li, Juan; Zhu, Rong; Gu, Zhongze

doi:10.1021/ac702249a

Cited by 215 publications

(209 citation statements)

References 52 publications

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“…For example, spherical inverse opal superparticles based on poly(ionic liquids) were used for recognition of various ions and solvents, 288,289 and protein-modified silica superparticles were used as coding carriers in multiplex immunoassays. 325 Additionally, the high surface area of the pores can be used for adsorption and triggered release of drugs in addition to sensing. 267 As shown in Figure 17C, temperature responsive spherical inverse opal superparticles change their color due to a change in the periodicity of their lattice when exposed to different temperatures.…”

Section: Factors Influencing Sensing Applicationsmentioning

confidence: 99%

A colloidoscope of colloid-based porous materials and their uses

et al. 2016

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Nature evolved a variety of hierarchical structures that produce sophisticated functions. Inspired by these natural materials, colloidal self-assembly provides a convenient way to produce structures from simple building blocks with a variety of complex functions beyond those found in nature. In particular, colloid-based porous materials (CBPM) can be made from a wide variety of materials. The internal structure of CBPM also has several key attributes, namely porosity on a sub-micrometer length scale, interconnectivity of these pores, and a controllable degree of order. The combination of structure and composition allow CBPM to attain properties important for modern applications such as photonic inks, colorimetric sensors, self-cleaning surfaces, water purification systems, or batteries. This review summarizes recent developments in the field of CBPM, including principles for their design, fabrication, and applications, with a particular focus on structural features and materials' properties that enable these applications. We begin with a short introduction to the wide variety of patterns that can be generated by colloidal self-assembly and templating processes. We then discuss different applications of such structures, focusing on optics, wetting, sensing, catalysis, and electrodes. Different fields of applications require different properties, yet the modularity of the assembly process of CBPM provides a high degree of tunability and tailorability in composition and structure. We examine the significance of properties such as structure, composition, and degree of order on the materials' functions and use, as well as trends in and future directions for the development of CBPM.

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Section: Factors Influencing Sensing Applicationsmentioning

confidence: 99%

A colloidoscope of colloid-based porous materials and their uses

et al. 2016

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“…When the mixture of microparticles was treated with fl uorescein isothiocyanate-tagged anti-human IgG and anti-rabbit IgG, only the red and green photonic microparticles produced fl uorescence, as shown in Figure 9(b). Microparticles coded with photonic bandgaps can thus be used in multiplex immunoassays [87]. Th e photonic bandgap is barely aff ected by fl uorescence signals, making it possible to perform more precise analyses compared with those conducted using dye or quantum dot-tagged microparticles, which produce code signals that can interfere with the fl uorescence.…”

Section: Biological Toolsmentioning

confidence: 99%

Self-assembled colloidal structures for photonics

et al. 2011

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A s dielectric structures with a submicrometer length scale can interact strongly with light, various remarkable optical responses can be designed and tailored depending on the types and parameters of their structures. Over the past few decades, the unusual optical properties of the periodic dielectric structures called photonic crystals have been investigated intensively [1]. Many research groups have endeavored to engineer the optical properties of photonic crystals, including photonic bandgaps, 'slow' photons, negative refraction and other properties, or to use them in practical applications. Two-dimensional (2D) structures, which are mostly prepared by conventional lithographic processes, were demonstrated initially, in which total internal refl ections were adopted for confi ning the light in a nonperiodic third direction, and their use has been investigated in some limited applications [2]. Th ree-dimensional (3D) structures have also been investigated intensively because of their complete photonic bandgaps in certain structures, a critical property for controlling light in 3D space. Research on such structures has been supported by the recent development of facile fabrication methods, including the selfassembly of simple monodisperse particles, also known as colloidal self-assembly [3], block copolymer self-assembly [4], the auto-cloning process [5] and holographic lithography [6]. Of these methods, colloidal self-assembly is the most promising for the low-cost production of 2D and 3D photonic crystals over large areas or with various shapes [7,8]. Schematic diagrams of the basic colloidal crystal structure along with inverse and short-range-ordered scattering structures for photonic applications are shown in Figure 1. Disordered dielectric structures of monodisperse particles called photonic glasses have begun to be investigated as another class of photonic nanostructures that can manifest some unusual optical phenomena such as random lasing, strong light localization and long-range intensity correlations. In this review article, we describe self-assembled colloidal photonic nanostructures in brief and summarize recent achievements in the fi eld of colloidal photonic nanostructures and their applications. Fabrication of photonic nanostructures by colloidal assembly Colloidal crystalsSince Vanderhoff 's serendipitous discovery of a synthetic method for preparing monodisperse polymer colloids [9], the method has been extended to the preparation of a variety of polymeric colloids and also to the processing of inorganic colloidal particles such as silica, titania and iron oxide. As long as particles are stable in liquid and their size distribution is suffi ciently narrow, they can be crystallized in a facecentered cubic (fcc) lattice by increasing their volume fraction through any concentration process, such as controlled evaporation, sedimentation or fi ltration. In general, the interparticle forces can be described by summing over the various potentials from diff erent origins, including intermolecular for...

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“…53 Studies and conceptual models/mechanisms to explain the paradox of high specificity and broader cross-reactivity remain speculative. It is therefore important to emphasize that despite mesmerizing innovations in measurements by immunoassays such as the use of multiplexed quantum dots nanoparticles to label antigens or antibodies, 56,57 interference will continue to occur, being an inherent part of the very basic antigen -antibody interaction, and hence the utility of probabilistic Bayesian reasoning as an aid to reduce false results (see Table 2). …”

Section: Comments and Conclusionmentioning

confidence: 99%

Probabilistic Bayesian reasoning can help identifying potentially wrong immunoassays results in clinical practice: even when they appear ‘not-unreasonable’

Ismail

2010

Ann Clin Biochem

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Background: Immunoassays are susceptible to analytical interferences including from endogenous immunoglobulin antibodies at a rate of 0.4% to 4%. Hundreds of millions of immunoassay tests (.10 millions in the UK alone) are performed yearly worldwide for measurements of an array of large and small moieties such as proteins, hormones, tumour markers, rheumatoid factor, troponin, small peptides, steroids and drugs. Methods: Interference in these tests can lead to false results which when suspected, or surmised, can be analytically confirmed in most cases. Suspecting false laboratory data in the first place is not difficult when results are gross and without clinical correlates. However, when false results are subtle and/or plausible, it can be difficult to suspect with adverse clinical sequelae. This problem can be ameliorated by using a probabilistic Bayesian reasoning to flag up potentially suspect results even when laboratory data appear "not-unreasonable". Results: Essentially, in disorders with low prevalence, the majority of positive results caused by analytical interference are likely to be false positives. On the other hand, when the disease prevalence is high, false negative results increase and become more significant. To illustrate the scope and utility of this approach, six different examples covering wide range of analytes are given, each highlighting specific aspect/nature of interference and suggested options to reduce it. Conclusion: Bayesian reasoning would allow laboratorians and/or clinicians to extract information about potentially false results, thus seeking follow-up confirmatory tests prior to the initiation of more expensive/invasive procedures or concluding a potentially wrong diagnosis.

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Encoded Silica Colloidal Crystal Beads as Supports for Potential Multiplex Immunoassay

Cited by 215 publications

References 52 publications

A colloidoscope of colloid-based porous materials and their uses

A colloidoscope of colloid-based porous materials and their uses

Self-assembled colloidal structures for photonics

Probabilistic Bayesian reasoning can help identifying potentially wrong immunoassays results in clinical practice: even when they appear ‘not-unreasonable’

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