End-to-side neurorrhaphy for nerve repair and function rehabilitation

Gao, Wansheng; Liu, Qin; Li, Songchao; Zhang, Jianwei; Li, Yansheng

doi:10.1016/j.jss.2015.03.100

Cited by 14 publications

(13 citation statements)

References 44 publications

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“…The pelvic preganglionic parasympathetic nerve (PPN) is completely composed of autonomic nerve fibers derived from L6 and S1 and synapses with postganglionic parasympathetic neurons, which is called as MPG that releases the nerve fibers to innervate the bladder, rectum, and penile erection [28-31]. Gao, et al [32] established an experimental model through intradural terminolateral neurorrhaphy between somatic nerve and autonomic nerve for repairing nerve and reconstructing bladder function, in which the left L6VR was anastomosed to the left L4VR that maintain L4VR intact in rats.…”

Section: Experimental Models Of Terminolateral Neurorrhaphy Of Autonomentioning

confidence: 99%

“…Gao, et al [32] and Dong, et al [34,35] demonstrated that nerve regeneration and functional recovery following terminolateral neurorrhaphy between somatic nerves and autonomic nerves with different characteristics was feasibility and the donor nerve function without getting impaired. This is a novel and original point of view, which provided a new way for the repair of damaged peripheral nerve injury in the future without damaging the donor nerve function.…”

Section: Terminolateral Neurorrhaphy Between Somatic Nerve and Autonomentioning

confidence: 99%

“…Secondly, when compared with conventional nerve grafts, Review Wansheng Gao, Jianguo Wen appearance of FG-FB double labeling neurons indicated that regenerated nerve fibers derived from collateral sprouting from the donor nerve [65]. Gao, et al [32] and Dong, et al [34,35] found that three kinds of labeled neurons of FB, FG and FB-FG all appeared in the L4 left ventral horn in the retrograde nerve tracing study following terminolateral neurorrhaphy. The results demonstrated that the artificial reflex pathway between somatic nerve and autonomic nerve have been established through terminolateral neurorrhaphy.…”

Section: The Advantages Of Terminolateral Neurorrhaphy Of Autonomic-smentioning

confidence: 99%

“…In order to prove that whether the artificial reflex pathway have been established and the mechanism of nerve regeneration through terminolateral neurorrhaphy between the L4VR (somatic nerve) and the L6VR (autonomic nerve), Gao, et al [32]and Dong, et al [34,35] injected Fast Blue (FB) and Fluoro-Gold (FG) into the SN and MPG, respectively. FB was blue labeling the cytoplasm, while FG was yellow labeling both the cytoplasm and nucleus under the excitation of ultraviolet light [62].…”

Section: The Mechanism Of Nerve Regeneration Of Terminolateral Neurormentioning

confidence: 99%

“…Terminolateral Neurorrhaphy between Somatic Nerve and Autonomic Nerve Gao [32] and Dong, et al [34,35] used the epineurium window during the intradural end-to-side microanastomosis between L4VR and L6VR. The appearance of unmyelinated and myelinated axons in the regenerated nerve fibers following terminolateral neurorrhaphy demonstrated that the somatic nerve could regenerate and grow into the distal end of the autonomic nerve.…”

Section: Reviewmentioning

confidence: 99%

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Terminolateral Neurorrhaphy between Somatic Nerve and Autonomic Nerve

He¹,

Gao²,

Wen³

2018

Neuropsychiatry

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Section: Experimental Models Of Terminolateral Neurorrhaphy Of Autonomentioning

confidence: 99%

Section: Terminolateral Neurorrhaphy Between Somatic Nerve and Autonomentioning

confidence: 99%

Section: The Advantages Of Terminolateral Neurorrhaphy Of Autonomic-smentioning

confidence: 99%

Section: The Mechanism Of Nerve Regeneration Of Terminolateral Neurormentioning

confidence: 99%

Section: Reviewmentioning

confidence: 99%

See 3 more Smart Citations

Terminolateral Neurorrhaphy between Somatic Nerve and Autonomic Nerve

He¹,

Gao²,

Wen³

2018

Neuropsychiatry

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Potassium titanyl phosphate laser welding following complete nerve transection

et al. 2016

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Prevention of denervated muscle atrophy with accelerated nerve‐regeneration by babysitter procedure in rat facial nerve paralysis model

et al. 2020

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Purpose The “babysitter” procedure is a reconstruction technique for facial nerve complete paralysis and uses the movement source from the healthy facial nerve with a cross‐nerve graft. First, an end‐to‐side neurorrhaphy is performed between the affected facial nerve trunk and hypoglossal nerve for continuously delivering stimuli to the mimetic muscles for preventing the atrophy of mimetic muscles. Despite favorable clinical results, histological and physiological mechanisms remain unknown. This study attempted to establish a model for the “babysitter” procedure and find its efficacy in rats with facial nerve complete paralysis. Materials and Methods A total of 16 Lewis rats were used and divided into 2 groups; cross nerve graft (n = 8) and babysitter groups (n = 8). The facial nerve trunk was transected in both groups. Babysitter group underwent a two‐stage procedure. Cross nerve graft group underwent only the transfer of nerve graft from the healthy side to affected side. The animals were assessed physiologically by compound muscle action potential (CMAP), and the regenerated nerve tissues were evaluated histopathologically at 13 weeks after surgery. Results Facial nucleus stained with retrograde tracers proved the re‐innervation of affected facial muscle by the babysitter procedure. In CMAP, the amplitude of babysitter group was significantly higher than that of the cross‐facial nerve graft group (p < .05). Histological examination found a significant difference in myelin g‐ratio between two groups (p < .05). Conclusion This study investigated the “babysitter” procedure for rat facial nerve palsy. Babysitter procedure shortened the denervation period without mimic muscle atrophy.

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End-to-side neurorrhaphy for nerve repair and function rehabilitation

Cited by 14 publications

References 44 publications

Terminolateral Neurorrhaphy between Somatic Nerve and Autonomic Nerve

Terminolateral Neurorrhaphy between Somatic Nerve and Autonomic Nerve

Potassium titanyl phosphate laser welding following complete nerve transection

Prevention of denervated muscle atrophy with accelerated nerve‐regeneration by babysitter procedure in rat facial nerve paralysis model

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