Endobronchial Hamartoma

Abstract

EH frequently produces respiratory complaints and radiographic abnormalities. Patients with endobronchial obstructions had satisfactory responses to endoscopic therapy.

Endobronchial Cartilaginous Hamartoma in a Wheezing Patient: A Case Report

“…Endobronchial hamartoma is a benign lesion made up of elements of lung and bronchus, generally including cartilaginous, osseous, fatty, and muscular tissue. Other authors have proposed that the hamartomas are mesenchymal clonal neoplasms instead of developmental abnormalities, because cytogenetic studies have indicated chromosomal bands of recombination located at positions 6p21 and 14q24 4) . Pulmonary hamartoma is rare, but is more common in men.…”

“…6) An endobronchial benign hamartoma is even rarer, accounting for 1.4-19.5% of all pulmonary hamartomas. 4,7) Generally, endobronchial hamartomas are detected during investigation of patients with symptoms related to obstructive pneumonia (cough and haemoptysis) or patients with atelectasis on chest X-ray films. Our patient complained of gradually progressive wheezing and persistent cough when he presented to a local clinic.…”

“…Pulmonary hamartomas typically develop in the peripheral lung parenchyma and are asymptomatic, but an occasional lesion arises in the bronchial tree and causes symptoms related to airway obstruction. [1][2][3][4] Endoscopic biopsy is often unable to provide enough information for diagnosis of pulmonary hamartoma because these lesions are covered by normal mucosa, so the diagnosis is usually established by histological examination of the resected specimen. Since these are benign tumours, minimally invasive treatment should be selected whenever possible.…”

Obstructive bronchial hamartoma

“…1,2 Malignant growth in lungs is the most frequent cause of bronchial obstruction in adults, with benign tumours accounting for a minority of instances. 2 Hamartomas are the most common benign endobronchial lesions.…”

“…3 Our case report illustrates that the cause of bronchial obstruction is not always malignant and that endoscopic techniques may spare patients the morbidity of thoracotomy and airway resection. 1,2 The prognosis in completely resected lesions is excellent. 1,2 …”