Endocan level in serum and lesional skin of psoriasis vulgaris patients

Gobrial, Christine K.; Asaad, Marwa K.; Seifeldin, Nevin S.; El-Sakhawy, Yasmin N; Abdelaziz, Doaa M.

doi:10.1097/01.ewx.0000521186.42934.0a

Cited by 3 publications

(4 citation statements)

References 19 publications

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“…Supporting our findings, Gobrial et al [15], demonstrated that endocan levels in serum and lesional skin showed statistically significant higher value in patients with psoriasis vulgaris and showed positive correlation with PASI score. They also reported that endocan levels in serum and tissue were significantly higher in patients with moderate to severe psoriasis than in those with mild disease.…”

Section: Discussionsupporting

confidence: 91%

Serum Endocan Levels in Patients with Psoriasis Vulgaris as a Marker of Disease Severity

Elgharib

Khalifa

Elasser

et al. 2019

Zagazig University Medical Journal

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Background: Endocan is a specific molecule of human endothelial cell. It was accepted as a marker of endothelial dysfunction that is widely involved in psoriasis development. Our aim was to evaluate the relation between serum endocan levels and severity of psoriasis vulgaris. Methods: Twenty-two patients with psoriasis vulgaris were involved. We measured serum endocan, c-reactive protein (CRP) and erythrocyte sedimentation rate (ESR). Psoriasis severity was evaluated by Psoriasis Area and Severity Index (PASI) score. Results: The mean serum level of endocan was 154±49.3 pg/ml with a range from 59 to 210 pg/ml. Its level was statistically significant increase in moderate and severe psoriatic patients compared to mild psoriatic patients. No statistically significant correlations were detected between serum endocan and CRP (P=0.11) and ESR(P=0.16). In contrast, a very highly statistically significant positive correlation was detected between endocan and disease severity(p=0.001). Conclusions: Serum endocan can be a promising marker that correlates with psoriasis vulgaris severity.

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Section: Discussionsupporting

confidence: 91%

Serum Endocan Levels in Patients with Psoriasis Vulgaris as a Marker of Disease Severity

Elgharib

Khalifa

Elasser

et al. 2019

Zagazig University Medical Journal

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“…But, in the control cases, endocan was expressed in 30% of cases in epidermis only with mild intensity and focal pattern. In agreement with our results, Gobrial et al 12 reported that endocan in lesional skin showed statistically significant higher value in psoriatic patients compared with control. Supporting our findings, Balta et al, 13 Farag et al, 14 Sabry et al, 15 and Elgarib et al, 16 reported that serum level of endocan in psoriatic patients was higher than that of the control group.…”

Section: Discussionsupporting

confidence: 94%

“…To the best of our knowledge, we are the second study to evaluate endocan expression in lesional skin of psoriasis after Gobrial et al 12 who studied the tissue lesional level of endocan in psoriasis by using sandwich enzyme immunoassay (enzyme‐linked immunosorbent assay) technique. The current study reported upregulation of endocan in the involved psoriatic skin (63.9% in epidermis and 36.1% in dermis) and absence of its expression in epidermis and dermis of the uninvolved skin biopsies.…”

Section: Discussionmentioning

confidence: 99%

The significance of endocan immunohistochemical expression in chronic plaque psoriasis

Abdou

Hammam

Saad

et al. 2021

J of Cosmetic Dermatology

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Background Psoriasis is a chronic inflammatory skin disease with immune‐mediated mechanism. Endocan is a soluble dermatan sulfate proteoglycan expressed by endothelium of blood vessels. Aims The present study aims to evaluate immunohistochemical localization of endocan in psoriatic skin in comparison with normal skin and to correlate its expression with the clinical and pathological data of psoriasis. Patients/Methods Skin biopsies from 36 psoriatic patients and 40 normal subjects were taken and processed for immunohistochemical staining of endocan. Results Endocan was expressed in 63.9% and in 36.1% of epidermal keratinocytes and dermal endothelial and inflammatory cells of psoriatic skin, respectively, compared with its expression in 30% of epidermis of normal skin. Diffuse epidermal expression of endocan was in favor of cases with more angiogenesis and its intense expression was in favor of marked acanthosis and with cases affecting trunk as main presentation. Positive dermal endocan expression was significantly associated with marked parakeratosis and with more angiogenesis. Conclusion Endocan is over‐expressed in psoriatic skin from epidermal keratinocytes and dermal endothelial and inflammatory cells. Endocan enhances angiogenesis and proliferation of psoriatic skin contributing to pathogenic mechanisms of psoriasis.

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“…It seems that endocan plays a role in the etiopathogenesis of psoriasis, since the levels of endocan in serum and lesional skin biopsies were significantly higher in the psoriatic group compared to the control group. It is plausible that endocan plays a role in the etiopathogenesis of psoriasis and contributes additional to the severity of the disease since blood and tissue endocan levels were much higher in patients with moderate-to-severe psoriasis compared to those with mild disease [34].…”

Section: Endocanmentioning

confidence: 99%

Evaluation of Serum Endocan Level and Erectile Functions in Patients with Psoriasis

El Esawy,

Abd El Khalik,

Abd EL-Ghafar

et al. 2024

Benha Journal of Applied Sciences

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Background: In psoriasis patients, circulating endocan is associated with disease severity and cardiovascular risk. Once again, endocan levels were correlated with inflammatory markers; individuals with psoriasis had greater amounts than controls. Elevated endocan levels may indicate inflammatory and endothelial factors contributing to erectile dysfunction pathophysiology (ED). As a new diagnostic indicator for the degree of erectile dysfunction, endocan could be helpful. The purpose of this review is to examine erectile dysfunction, serum endocan levels, psoriasis epidemiology, and pathophysiology in great detail. The endothelial and inflammatory components of the aetiology of both psoriasis and erectile dysfunction may be represented by increased endocan levels, according to the conclusions. One possible use for endocan is as a diagnostic marker for erectile dysfunction and psoriasis.

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Endocan level in serum and lesional skin of psoriasis vulgaris patients

Cited by 3 publications

References 19 publications

Serum Endocan Levels in Patients with Psoriasis Vulgaris as a Marker of Disease Severity

Serum Endocan Levels in Patients with Psoriasis Vulgaris as a Marker of Disease Severity

The significance of endocan immunohistochemical expression in chronic plaque psoriasis

Evaluation of Serum Endocan Level and Erectile Functions in Patients with Psoriasis

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