Endocardial Mapping of Electrophysiologically Abnormal Substrates and Cardiac Arrhythmias Using a Noncontact Nonexpandable Catheter

Jia, Ping; Punske, Bonnie B.; Taccardi, Bruno; Rudy, Yoram

doi:10.1046/j.1540-8167.2002.00888.x

Cited by 3 publications

(2 citation statements)

References 22 publications

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“…By lowering the financial threshold for implementing panoramic optical mapping, building a system that combines panoramic optical mapping with electrical mapping may be feasible while maintaining cost containment. For instance, simultaneous panoramic imaging and endocardial mapping using a balloon electrode array would provide both epicardial and endocardial information, respectively, which are both relevant in the study of ventricular arrhythmias 35 36 37 . Furthermore, doing both of these measurements in a torso-tank fitted with hundreds of body-surface electrodes would simultaneously provide a complete set of electrocardiogram information on the pseudo-torso surface 38 39 .…”

Section: Discussionmentioning

confidence: 99%

Low-Cost Optical Mapping Systems for Panoramic Imaging of Complex Arrhythmias and Drug-Action in Translational Heart Models

Lee

Calvo

Alfonso-Almazán

et al. 2017

Sci Rep

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Panoramic optical mapping is the primary method for imaging electrophysiological activity from the entire outer surface of Langendorff-perfused hearts. To date, it is the only method of simultaneously measuring multiple key electrophysiological parameters, such as transmembrane voltage and intracellular free calcium, at high spatial and temporal resolution. Despite the impact it has already had on the fields of cardiac arrhythmias and whole-heart computational modeling, present-day system designs precludes its adoption by the broader cardiovascular research community because of their high costs. Taking advantage of recent technological advances, we developed and validated low-cost optical mapping systems for panoramic imaging using Langendorff-perfused pig hearts, a clinically-relevant model in basic research and bioengineering. By significantly lowering financial thresholds, this powerful cardiac electrophysiology imaging modality may gain wider use in research and, even, teaching laboratories, which we substantiated using the lower-cost Langendorff-perfused rabbit heart model.

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Section: Discussionmentioning

confidence: 99%

Low-Cost Optical Mapping Systems for Panoramic Imaging of Complex Arrhythmias and Drug-Action in Translational Heart Models

Lee

Calvo

Alfonso-Almazán

et al. 2017

Sci Rep

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“…We evaluated GMRes on 21 data sets pertaining to studies that were previously published. 2,3,9,15,16,24,28 Here, we present selected results from six protocols that have implications to the clinical application of ECGI. GMRes performance was similar for the remaining 15 protocols.…”

Section: Experimental Methods and Protocolsmentioning

confidence: 99%

Noninvasive Electrocardiographic Imaging (ECGI): Application of the Generalized Minimal Residual (GMRes) Method

Ramanathan

Jia

Ghanem

et al. 2003

Annals of Biomedical Engineering

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Electrocardiographic imaging (ECGI) is a developing imaging modality for cardiac electrophysiology and arrhythmias. It reconstructs epicardial potentials, electrograms, and isochrones from electrocardiographic body-surface potentials noninvasively. Current ECGI methodology employs Tikhonov regularization, which imposes constraints on the reconstructed potentials or their derivatives. This approach can sometimes reduce spatial resolution by smoothing the solution. Accuracy depends on a priori knowledge of solution characteristics and determination of an optimal regularization parameter. These properties led us to implement an independent, iterative approach for ECGI--the generalized minimal residual (GMRes) method--which does not apply constraints. GMRes was applied to experimental data during activation/repolarization of normal and infarcted hearts. GMRes reconstructions were compared to Tikhonov reconstructions and to measured "gold standards" in isolated hearts. Overall, the accuracy of GMRes solutions was similar to Tikhonov regularization. However, in certain cases GMRes recovered localized potential features (e.g., multiple potential minima), which were lost in the Tikhonov solution. Simultaneous use of these two complementary methods in clinical ECGI will ensure reliability and maximal extraction of diagnostic information in the absence of a priori information about a patient's condition.

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Contributions To The Methodology Of Electrocardiographic Imaging (ECGI) And Application Of ECGI To Study Mechanisms Of Atrial Arrhythmia, Post Myocardial Infarction Electrophysiological Substrate, And

Wang¹

2009

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Endocardial Mapping of Electrophysiologically Abnormal Substrates and Cardiac Arrhythmias Using a Noncontact Nonexpandable Catheter

Cited by 3 publications

References 22 publications

Low-Cost Optical Mapping Systems for Panoramic Imaging of Complex Arrhythmias and Drug-Action in Translational Heart Models

Low-Cost Optical Mapping Systems for Panoramic Imaging of Complex Arrhythmias and Drug-Action in Translational Heart Models

Noninvasive Electrocardiographic Imaging (ECGI): Application of the Generalized Minimal Residual (GMRes) Method

Contributions To The Methodology Of Electrocardiographic Imaging (ECGI) And Application Of ECGI To Study Mechanisms Of Atrial Arrhythmia, Post Myocardial Infarction Electrophysiological Substrate, And

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